The proximal interferon-stimulated response elements are essential for interferon responsiveness: a promoter analysis of the antiviral MxA gene

Interferon (IFN)-inducible human MxA protein mediates resistance against influenza and several other RNA viruses. The MxA gene is under the control of type I IFN and, in certain cell types, is also directly activated by viruses. Here we show that in human macrophages, MxA mRNA levels are upregulated...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of interferon & cytokine research 1998-09, Vol.18 (9), p.773-781
Hauptverfasser:	Ronni, T, Matikainen, S, Lehtonen, A, Palvimo, J, Dellis, J, Van Eylen, F, Goetschy, J F, Horisberger, M, Content, J, Julkunen, I
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - genetics Antiviral Agents - pharmacology Base Sequence DNA-Binding Proteins - metabolism GTP Phosphohydrolases - genetics GTP-Binding Proteins Humans Interferon-alpha - pharmacology Interferon-Stimulated Gene Factor 3 Interferon-Stimulated Gene Factor 3, gamma Subunit Macrophages - drug effects Macrophages - metabolism Molecular Sequence Data Myxovirus Resistance Proteins Promoter Regions, Genetic Proteins - genetics Response Elements RNA, Messenger - biosynthesis Stimulation, Chemical Transcription Factors - metabolism Up-Regulation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!