An in vivo, ex vivo and in vitro comparative study of activity of copper oligopeptide complexes vs Cu(II) ions

The tetrapeptide-Cu(II) complex H-(l-His-Gly)2-OH/Cu(II), indicated as L-Cu(II), has been investigated, as compared to the Cu(II) inorganic salt CuSO4, for its antioxidative and anti-inflammatory properties under a panel of experimental conditions. Both inorganic and organic Cu(II) compounds showed...

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Veröffentlicht in:	Pharmacological research 1998-10, Vol.38 (4), p.279-287
Hauptverfasser:	Ciuffi, M, Cellai, C, Franchi-Micheli, S, Zilletti, L, Ginanneschi, M, Chelli, M, Papini, A M, Paoletti, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - therapeutic use Antioxidants - pharmacology Carrageenan Cations, Divalent - pharmacology Cerebral Cortex - chemistry Cerebral Cortex - drug effects Cerebral Cortex - metabolism Copper - pharmacology Cytochrome c Group - pharmacology Dose-Response Relationship, Drug Edema - chemically induced Edema - drug therapy Foot - pathology Free Radical Scavengers - metabolism Guinea Pigs Lipid Peroxidation - drug effects Lipid Peroxides - metabolism Macrophages, Alveolar - chemistry Macrophages, Alveolar - drug effects Macrophages, Alveolar - metabolism N-Formylmethionine Leucyl-Phenylalanine - pharmacology Oligopeptides - pharmacology Organometallic Compounds - pharmacology Rats Rats, Wistar Superoxide Dismutase - metabolism Superoxides - metabolism
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