Biological Properties of Biotin--Chelate Conjugates for Pretargeted Diagnosis and Therapy with the Avidin/Biotin System

Three-step pretargeting increases target-to-background ratios in radioimmunodetection and can potentially decrease harmful radiation to normal tissues in radioimmunotherapy. We studied four biotin-chelate conjugates (BCCs) for use in the avidin/biotin pretargeting system. Pharmacokinetics and biodis...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 1998-10, Vol.39 (10), p.1813-1818
Hauptverfasser:	Goodwin, David A, Meares, Claude F, Osen, Maureen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biotin Chelating Agents Contrast media. Radiopharmaceuticals Indium Radioisotopes - therapeutic use Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, SCID Pharmacology. Drug treatments Radioimmunodetection Radioimmunotherapy Streptavidin Tissue Distribution Yttrium Radioisotopes - therapeutic use
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