Nociceptin receptors in the rat spinal cord during morphine tolerance

The anatomical localization of nociceptin receptors was examined by in vitro quantitative autoradiography techniques in rat spinal cord sections by using [ 125 I –Tyr 14]nociceptin. [ 125 I –Tyr 14]nociceptin appeared to interact with a single class of binding sites ( K D=0.1 nM) present in the grey...

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Veröffentlicht in:	Brain research 1999-08, Vol.838 (1), p.85-94
Hauptverfasser:	Gouardères, C, Tafani, J.A.M, Meunier, J.-C, Jhamandas, K, Zajac, J.-M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analgesics, Opioid - pharmacology Anatomy Animals Autoradiography Biological and medical sciences Central nervous system Drug Tolerance Fundamental and applied biological sciences. Psychology Iodine Radioisotopes Male Molecular Sequence Data Morphine - pharmacology Nociceptin Radioligand Assay Rat Rats Rats, Sprague-Dawley Receptor Receptors, Opioid - analysis Receptors, Opioid - drug effects Spinal cord Spinal Cord - chemistry Spinal Cord - drug effects Vertebrates: nervous system and sense organs
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