A Beneficial Effect on Mood in Partial Epilepsy Patients Treated with Gabapentin
Purpose: Antiepileptic drugs (AEDs) are frequently used for their beneficial psychoactive effects on affective disorders. We sought to demonstrate a psychoactive effect of gabapentin (GBP) when used as add‐on AED therapy. Methods: Forty adult patients with partial epilepsy were studied in a prospect...
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| Veröffentlicht in: | Epilepsia (Copenhagen) 1999-08, Vol.40 (8), p.1129-1134 |
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| container_title | Epilepsia (Copenhagen) |
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| creator | Harden, Cynthia L. Lazar, Lorraine M. Pick, Lawrence H. Nikolov, Blagovest Goldstein, Martin A. Carson, Deborah Ravdin, Lisa D. Kocsis, James H. Labar, Douglas R. |
| description | Purpose: Antiepileptic drugs (AEDs) are frequently used for their beneficial psychoactive effects on affective disorders. We sought to demonstrate a psychoactive effect of gabapentin (GBP) when used as add‐on AED therapy.
Methods: Forty adult patients with partial epilepsy were studied in a prospective, non‐randomized fashion with interviewer‐rated and self‐rated scales of mood and anxiety: the Cornell Dysthymia Rating Scale (CDRS), Beck Depression Inventory (BDI), and Hamilton Depression (Ham‐D) and Anxiety (Ham‐A) Scales. After completion of baseline mood and anxiety scales (time 1), 20 of the 40 patients were prescribed add‐on GBP (treated group). The remaining 20 patients served as a control group. Both groups were similar in age and sex distribution. Follow‐up mood and anxiety scales were performed in all patients ∼3 months later (time 2). The average GBP dose at time 2 was 1,615 mg/day. All patients were taking stable doses of one to four AEDs at baseline and throughout the study. Seizure frequency was monitored throughout. Statistical significance was assessed by analysis of variance (ANOVA) by using a two‐factor repeated‐measures model.
Results: The GBP‐treated group had a significant decrease in CDRS score over time compared with the control group (p = 0.04). No significant differences between the control and the treated groups were found for any of the remaining mood scales (BDI, p = 0.58; Ham‐D, p = 0.59; Ham‐A, p = 0.93). There was no significant difference or change in seizure frequency between groups.
Conclusions: GBP treatment is associated with mood improvement as measured by the CDRS. This improvement was not accounted for by seizure improvement. |
| doi_str_mv | 10.1111/j.1528-1157.1999.tb00830.x |
| format | Article |
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Methods: Forty adult patients with partial epilepsy were studied in a prospective, non‐randomized fashion with interviewer‐rated and self‐rated scales of mood and anxiety: the Cornell Dysthymia Rating Scale (CDRS), Beck Depression Inventory (BDI), and Hamilton Depression (Ham‐D) and Anxiety (Ham‐A) Scales. After completion of baseline mood and anxiety scales (time 1), 20 of the 40 patients were prescribed add‐on GBP (treated group). The remaining 20 patients served as a control group. Both groups were similar in age and sex distribution. Follow‐up mood and anxiety scales were performed in all patients ∼3 months later (time 2). The average GBP dose at time 2 was 1,615 mg/day. All patients were taking stable doses of one to four AEDs at baseline and throughout the study. Seizure frequency was monitored throughout. Statistical significance was assessed by analysis of variance (ANOVA) by using a two‐factor repeated‐measures model.
Results: The GBP‐treated group had a significant decrease in CDRS score over time compared with the control group (p = 0.04). No significant differences between the control and the treated groups were found for any of the remaining mood scales (BDI, p = 0.58; Ham‐D, p = 0.59; Ham‐A, p = 0.93). There was no significant difference or change in seizure frequency between groups.
Conclusions: GBP treatment is associated with mood improvement as measured by the CDRS. This improvement was not accounted for by seizure improvement.</description><identifier>ISSN: 0013-9580</identifier><identifier>EISSN: 1528-1167</identifier><identifier>DOI: 10.1111/j.1528-1157.1999.tb00830.x</identifier><identifier>PMID: 10448827</identifier><identifier>CODEN: EPILAK</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Acetates - pharmacology ; Acetates - therapeutic use ; Adult ; Affect - drug effects ; Aged ; Amines ; Anticonvulsants - pharmacology ; Anticonvulsants - therapeutic use ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Anxiety Disorders - drug therapy ; Anxiety Disorders - epidemiology ; Anxiety Disorders - psychology ; Biological and medical sciences ; Comorbidity ; Cyclohexanecarboxylic Acids ; Depression ; Depressive Disorder - drug therapy ; Depressive Disorder - epidemiology ; Depressive Disorder - psychology ; Drug Therapy, Combination ; Dysthymia ; Epilepsies, Partial - drug therapy ; Epilepsies, Partial - epidemiology ; Epilepsies, Partial - psychology ; Epilepsy ; Female ; Gabapentin ; gamma-Aminobutyric Acid ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Male ; Medical sciences ; Middle Aged ; Mood ; Nervous system (semeiology, syndromes) ; Neurology ; Neuropharmacology ; Personality Inventory - statistics & numerical data ; Pharmacology. Drug treatments ; Prospective Studies ; Psychiatric Status Rating Scales - statistics & numerical data ; Treatment Outcome</subject><ispartof>Epilepsia (Copenhagen), 1999-08, Vol.40 (8), p.1129-1134</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4529-9da4fdb084c79de1c7401fe631efbf1014fd704317015aff0b69bfd99adae1d3</citedby><cites>FETCH-LOGICAL-c4529-9da4fdb084c79de1c7401fe631efbf1014fd704317015aff0b69bfd99adae1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1528-1157.1999.tb00830.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1528-1157.1999.tb00830.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1899398$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10448827$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harden, Cynthia L.</creatorcontrib><creatorcontrib>Lazar, Lorraine M.</creatorcontrib><creatorcontrib>Pick, Lawrence H.</creatorcontrib><creatorcontrib>Nikolov, Blagovest</creatorcontrib><creatorcontrib>Goldstein, Martin A.</creatorcontrib><creatorcontrib>Carson, Deborah</creatorcontrib><creatorcontrib>Ravdin, Lisa D.</creatorcontrib><creatorcontrib>Kocsis, James H.</creatorcontrib><creatorcontrib>Labar, Douglas R.</creatorcontrib><title>A Beneficial Effect on Mood in Partial Epilepsy Patients Treated with Gabapentin</title><title>Epilepsia (Copenhagen)</title><addtitle>Epilepsia</addtitle><description>Purpose: Antiepileptic drugs (AEDs) are frequently used for their beneficial psychoactive effects on affective disorders. We sought to demonstrate a psychoactive effect of gabapentin (GBP) when used as add‐on AED therapy.
Methods: Forty adult patients with partial epilepsy were studied in a prospective, non‐randomized fashion with interviewer‐rated and self‐rated scales of mood and anxiety: the Cornell Dysthymia Rating Scale (CDRS), Beck Depression Inventory (BDI), and Hamilton Depression (Ham‐D) and Anxiety (Ham‐A) Scales. After completion of baseline mood and anxiety scales (time 1), 20 of the 40 patients were prescribed add‐on GBP (treated group). The remaining 20 patients served as a control group. Both groups were similar in age and sex distribution. Follow‐up mood and anxiety scales were performed in all patients ∼3 months later (time 2). The average GBP dose at time 2 was 1,615 mg/day. All patients were taking stable doses of one to four AEDs at baseline and throughout the study. Seizure frequency was monitored throughout. Statistical significance was assessed by analysis of variance (ANOVA) by using a two‐factor repeated‐measures model.
Results: The GBP‐treated group had a significant decrease in CDRS score over time compared with the control group (p = 0.04). No significant differences between the control and the treated groups were found for any of the remaining mood scales (BDI, p = 0.58; Ham‐D, p = 0.59; Ham‐A, p = 0.93). There was no significant difference or change in seizure frequency between groups.
Conclusions: GBP treatment is associated with mood improvement as measured by the CDRS. This improvement was not accounted for by seizure improvement.</description><subject>Acetates - pharmacology</subject><subject>Acetates - therapeutic use</subject><subject>Adult</subject><subject>Affect - drug effects</subject><subject>Aged</subject><subject>Amines</subject><subject>Anticonvulsants - pharmacology</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Anxiety Disorders - drug therapy</subject><subject>Anxiety Disorders - epidemiology</subject><subject>Anxiety Disorders - psychology</subject><subject>Biological and medical sciences</subject><subject>Comorbidity</subject><subject>Cyclohexanecarboxylic Acids</subject><subject>Depression</subject><subject>Depressive Disorder - drug therapy</subject><subject>Depressive Disorder - epidemiology</subject><subject>Depressive Disorder - psychology</subject><subject>Drug Therapy, Combination</subject><subject>Dysthymia</subject><subject>Epilepsies, Partial - drug therapy</subject><subject>Epilepsies, Partial - epidemiology</subject><subject>Epilepsies, Partial - psychology</subject><subject>Epilepsy</subject><subject>Female</subject><subject>Gabapentin</subject><subject>gamma-Aminobutyric Acid</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mood</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Neuropharmacology</subject><subject>Personality Inventory - statistics & numerical data</subject><subject>Pharmacology. Drug treatments</subject><subject>Prospective Studies</subject><subject>Psychiatric Status Rating Scales - statistics & numerical data</subject><subject>Treatment Outcome</subject><issn>0013-9580</issn><issn>1528-1167</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE1rGzEQhkVpqJ20f6GIUnrbzYz3Q6teShqcD3CID74LrTSiMuvd7WpN4n8fOV5IrpmLYN5nZsTD2A-EFGNdblMsFlWCWIgUpZTpWANUGaTPn9h8ikrxmc0BMEtkUcGMnYewBQBRiuwLmyHkeVUtxJytr_hfasl543XDl86RGXnX8oeus9y3fK2H8TXpfUN9OMTG6KkdA98MpEey_MmP__itrnUf2779ys6cbgJ9m94LtrlZbq7vktXj7f311SoxebGQibQ6d7aGKjdCWkIjckBHZYbkaoeAMRWQZygAC-0c1KWsnZVSW01oswv267S2H7r_ewqj2vlgqGl0S90-qFLKEiAXEfx9As3QhTCQU_3gd3o4KAR11Km26uhMHXWqo0416VTPcfj7dGVf78i-Gz35i8DPCdDB6MYNujU-vHGVlJmsIvbnhD1Fi4cP_EAt1_eIC5m9ALybkiM</recordid><startdate>199908</startdate><enddate>199908</enddate><creator>Harden, Cynthia L.</creator><creator>Lazar, Lorraine M.</creator><creator>Pick, Lawrence H.</creator><creator>Nikolov, Blagovest</creator><creator>Goldstein, Martin A.</creator><creator>Carson, Deborah</creator><creator>Ravdin, Lisa D.</creator><creator>Kocsis, James H.</creator><creator>Labar, Douglas R.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199908</creationdate><title>A Beneficial Effect on Mood in Partial Epilepsy Patients Treated with Gabapentin</title><author>Harden, Cynthia L. ; Lazar, Lorraine M. ; Pick, Lawrence H. ; Nikolov, Blagovest ; Goldstein, Martin A. ; Carson, Deborah ; Ravdin, Lisa D. ; Kocsis, James H. ; Labar, Douglas R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4529-9da4fdb084c79de1c7401fe631efbf1014fd704317015aff0b69bfd99adae1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Acetates - pharmacology</topic><topic>Acetates - therapeutic use</topic><topic>Adult</topic><topic>Affect - drug effects</topic><topic>Aged</topic><topic>Amines</topic><topic>Anticonvulsants - pharmacology</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Anticonvulsants. Antiepileptics. Antiparkinson agents</topic><topic>Anxiety Disorders - drug therapy</topic><topic>Anxiety Disorders - epidemiology</topic><topic>Anxiety Disorders - psychology</topic><topic>Biological and medical sciences</topic><topic>Comorbidity</topic><topic>Cyclohexanecarboxylic Acids</topic><topic>Depression</topic><topic>Depressive Disorder - drug therapy</topic><topic>Depressive Disorder - epidemiology</topic><topic>Depressive Disorder - psychology</topic><topic>Drug Therapy, Combination</topic><topic>Dysthymia</topic><topic>Epilepsies, Partial - drug therapy</topic><topic>Epilepsies, Partial - epidemiology</topic><topic>Epilepsies, Partial - psychology</topic><topic>Epilepsy</topic><topic>Female</topic><topic>Gabapentin</topic><topic>gamma-Aminobutyric Acid</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mood</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Neuropharmacology</topic><topic>Personality Inventory - statistics & numerical data</topic><topic>Pharmacology. Drug treatments</topic><topic>Prospective Studies</topic><topic>Psychiatric Status Rating Scales - statistics & numerical data</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harden, Cynthia L.</creatorcontrib><creatorcontrib>Lazar, Lorraine M.</creatorcontrib><creatorcontrib>Pick, Lawrence H.</creatorcontrib><creatorcontrib>Nikolov, Blagovest</creatorcontrib><creatorcontrib>Goldstein, Martin A.</creatorcontrib><creatorcontrib>Carson, Deborah</creatorcontrib><creatorcontrib>Ravdin, Lisa D.</creatorcontrib><creatorcontrib>Kocsis, James H.</creatorcontrib><creatorcontrib>Labar, Douglas R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Epilepsia (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harden, Cynthia L.</au><au>Lazar, Lorraine M.</au><au>Pick, Lawrence H.</au><au>Nikolov, Blagovest</au><au>Goldstein, Martin A.</au><au>Carson, Deborah</au><au>Ravdin, Lisa D.</au><au>Kocsis, James H.</au><au>Labar, Douglas R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Beneficial Effect on Mood in Partial Epilepsy Patients Treated with Gabapentin</atitle><jtitle>Epilepsia (Copenhagen)</jtitle><addtitle>Epilepsia</addtitle><date>1999-08</date><risdate>1999</risdate><volume>40</volume><issue>8</issue><spage>1129</spage><epage>1134</epage><pages>1129-1134</pages><issn>0013-9580</issn><eissn>1528-1167</eissn><coden>EPILAK</coden><abstract>Purpose: Antiepileptic drugs (AEDs) are frequently used for their beneficial psychoactive effects on affective disorders. We sought to demonstrate a psychoactive effect of gabapentin (GBP) when used as add‐on AED therapy.
Methods: Forty adult patients with partial epilepsy were studied in a prospective, non‐randomized fashion with interviewer‐rated and self‐rated scales of mood and anxiety: the Cornell Dysthymia Rating Scale (CDRS), Beck Depression Inventory (BDI), and Hamilton Depression (Ham‐D) and Anxiety (Ham‐A) Scales. After completion of baseline mood and anxiety scales (time 1), 20 of the 40 patients were prescribed add‐on GBP (treated group). The remaining 20 patients served as a control group. Both groups were similar in age and sex distribution. Follow‐up mood and anxiety scales were performed in all patients ∼3 months later (time 2). The average GBP dose at time 2 was 1,615 mg/day. All patients were taking stable doses of one to four AEDs at baseline and throughout the study. Seizure frequency was monitored throughout. Statistical significance was assessed by analysis of variance (ANOVA) by using a two‐factor repeated‐measures model.
Results: The GBP‐treated group had a significant decrease in CDRS score over time compared with the control group (p = 0.04). No significant differences between the control and the treated groups were found for any of the remaining mood scales (BDI, p = 0.58; Ham‐D, p = 0.59; Ham‐A, p = 0.93). There was no significant difference or change in seizure frequency between groups.
Conclusions: GBP treatment is associated with mood improvement as measured by the CDRS. This improvement was not accounted for by seizure improvement.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>10448827</pmid><doi>10.1111/j.1528-1157.1999.tb00830.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acetates - pharmacology Acetates - therapeutic use Adult Affect - drug effects Aged Amines Anticonvulsants - pharmacology Anticonvulsants - therapeutic use Anticonvulsants. Antiepileptics. Antiparkinson agents Anxiety Disorders - drug therapy Anxiety Disorders - epidemiology Anxiety Disorders - psychology Biological and medical sciences Comorbidity Cyclohexanecarboxylic Acids Depression Depressive Disorder - drug therapy Depressive Disorder - epidemiology Depressive Disorder - psychology Drug Therapy, Combination Dysthymia Epilepsies, Partial - drug therapy Epilepsies, Partial - epidemiology Epilepsies, Partial - psychology Epilepsy Female Gabapentin gamma-Aminobutyric Acid Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Male Medical sciences Middle Aged Mood Nervous system (semeiology, syndromes) Neurology Neuropharmacology Personality Inventory - statistics & numerical data Pharmacology. Drug treatments Prospective Studies Psychiatric Status Rating Scales - statistics & numerical data Treatment Outcome |
| title | A Beneficial Effect on Mood in Partial Epilepsy Patients Treated with Gabapentin |
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