$Metabolism of primaquine by liver homogenate fractions. Evidence for monoamine oxidase and cytochrome P450 involvement in the oxidative deamination of primaquine to carboxyprimaquine$

Metabolism of primaquine by liver homogenate fractions. Evidence for monoamine oxidase and cytochrome P450 involvement in the oxidative deamination of primaquine to carboxyprimaquine

The role of monoamine oxidase (MAO) and cytochrome P450 (P450) in the oxidative deamination of primaquine by rat liver fractions was studied. Rat liver fractions including liver homogenate, mitochondria, microsomes and 100,000 g supematant fractions were prepared from a pool of rat livers and charac...

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Veröffentlicht in:	Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1999-07, Vol.51 (4-5), p.299-303
Hauptverfasser:	Constantino, L, Paixão, P, Moreira, R, Portela, M J, Do Rosario, V E, Iley, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimalarials - metabolism Cell Fractionation Chromatography, High Pressure Liquid Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - metabolism Drug Combinations Drugs, Chinese Herbal - pharmacology Enzyme Inhibitors Liver - enzymology Liver - ultrastructure Male Microsomes, Liver - enzymology Mitochondria, Liver - enzymology Monoamine Oxidase - metabolism Monoamine Oxidase Inhibitors - pharmacology Pargyline - pharmacology Primaquine - metabolism Rats Rats, Wistar
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