Production of lysophosphatidic acid by lysophospholipase D in incubated plasma of spontaneously hypertensive rats and Wistar Kyoto rats
Lysophosphatidic acid has been identified as a vasopressor principle in incubated mammalian plasma and sera, and shown to be generated extracellulary by lysophospholipase D-like activity. In this study, we monitored the time course of changes in the major phospholipid fractions during incubation of...
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| Veröffentlicht in: | Life sciences (1973) 1999, Vol.65 (3), p.245-253 |
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| container_title | Life sciences (1973) |
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| creator | Tokumura, Akira Fujimoto, Hiroaki Yoshimoto, Osamu Nishioka, Yuko Miyake, Maki Fukuzawa, Kenji |
| description | Lysophosphatidic acid has been identified as a vasopressor principle in incubated mammalian plasma and sera, and shown to be generated extracellulary by lysophospholipase D-like activity. In this study, we monitored the time course of changes in the major phospholipid fractions during incubation of plasma, and found that polyunsaturated lysophosphatidic acids accumulate more rapidly than saturated lysophosphatidic acids at expense of the corresponding lysophosphatidylcholines. We compared the phospholipase activities for producing bioactive LPA in age-matched spontaeneously hypertensive rats and Wistar Kyoto rats. The lysophospholipase D activity in rat plasma was found to be independent of strain and age. We suggest that lysophospholipase D functions in rat for persistent production of bioactive LPA in the circulation throughout life. However, our finding that production of LPA in spontaenously hypertensive rats was not greater than that in Wistar Kyoto rats does not seem to support the idea that increased production of LPA is involved in the pathogenesis of hypertension. |
| doi_str_mv | 10.1016/S0024-3205(99)00243-X |
| format | Article |
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In this study, we monitored the time course of changes in the major phospholipid fractions during incubation of plasma, and found that polyunsaturated lysophosphatidic acids accumulate more rapidly than saturated lysophosphatidic acids at expense of the corresponding lysophosphatidylcholines. We compared the phospholipase activities for producing bioactive LPA in age-matched spontaeneously hypertensive rats and Wistar Kyoto rats. The lysophospholipase D activity in rat plasma was found to be independent of strain and age. We suggest that lysophospholipase D functions in rat for persistent production of bioactive LPA in the circulation throughout life. However, our finding that production of LPA in spontaenously hypertensive rats was not greater than that in Wistar Kyoto rats does not seem to support the idea that increased production of LPA is involved in the pathogenesis of hypertension.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/S0024-3205(99)00243-X</identifier><identifier>PMID: 10447209</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>aging ; Aging - metabolism ; Animals ; Chromatography, Gas ; Chromatography, Thin Layer ; Fatty Acids - analysis ; In Vitro Techniques ; lecithin:cholesterol acyltransferase ; lysophosphatidic acid ; lysophosphatidylcholine ; lysophospholipase D ; Lysophospholipids - biosynthesis ; Lysophospholipids - blood ; Lysophospholipids - chemistry ; Male ; Phosphatidylcholines - blood ; Phosphoric Diester Hydrolases - blood ; Phosphoric Diester Hydrolases - metabolism ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Species Specificity ; spontaneously hypertensive rat ; Time Factors</subject><ispartof>Life sciences (1973), 1999, Vol.65 (3), p.245-253</ispartof><rights>1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-7fb37be569e27a40ae7721516e39da78d444662929ad68efc6da76e29c7cbecc3</citedby><cites>FETCH-LOGICAL-c427t-7fb37be569e27a40ae7721516e39da78d444662929ad68efc6da76e29c7cbecc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0024-3205(99)00243-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,4010,27904,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10447209$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tokumura, Akira</creatorcontrib><creatorcontrib>Fujimoto, Hiroaki</creatorcontrib><creatorcontrib>Yoshimoto, Osamu</creatorcontrib><creatorcontrib>Nishioka, Yuko</creatorcontrib><creatorcontrib>Miyake, Maki</creatorcontrib><creatorcontrib>Fukuzawa, Kenji</creatorcontrib><title>Production of lysophosphatidic acid by lysophospholipase D in incubated plasma of spontaneously hypertensive rats and Wistar Kyoto rats</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Lysophosphatidic acid has been identified as a vasopressor principle in incubated mammalian plasma and sera, and shown to be generated extracellulary by lysophospholipase D-like activity. In this study, we monitored the time course of changes in the major phospholipid fractions during incubation of plasma, and found that polyunsaturated lysophosphatidic acids accumulate more rapidly than saturated lysophosphatidic acids at expense of the corresponding lysophosphatidylcholines. We compared the phospholipase activities for producing bioactive LPA in age-matched spontaeneously hypertensive rats and Wistar Kyoto rats. The lysophospholipase D activity in rat plasma was found to be independent of strain and age. We suggest that lysophospholipase D functions in rat for persistent production of bioactive LPA in the circulation throughout life. However, our finding that production of LPA in spontaenously hypertensive rats was not greater than that in Wistar Kyoto rats does not seem to support the idea that increased production of LPA is involved in the pathogenesis of hypertension.</description><subject>aging</subject><subject>Aging - metabolism</subject><subject>Animals</subject><subject>Chromatography, Gas</subject><subject>Chromatography, Thin Layer</subject><subject>Fatty Acids - analysis</subject><subject>In Vitro Techniques</subject><subject>lecithin:cholesterol acyltransferase</subject><subject>lysophosphatidic acid</subject><subject>lysophosphatidylcholine</subject><subject>lysophospholipase D</subject><subject>Lysophospholipids - biosynthesis</subject><subject>Lysophospholipids - blood</subject><subject>Lysophospholipids - chemistry</subject><subject>Male</subject><subject>Phosphatidylcholines - blood</subject><subject>Phosphoric Diester Hydrolases - blood</subject><subject>Phosphoric Diester Hydrolases - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Rats, Inbred WKY</subject><subject>Species Specificity</subject><subject>spontaneously hypertensive rat</subject><subject>Time Factors</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkdtq3DAQhkVoabZpHyFFV6W9cCLJtrS6KiVtDjSQQluaOyFLY1bFazkaOeAnyGvHuw4hdwWB0Oibfw4_IcecnXDG5ekvxkRVlILVn7T-vHuUxe0BWfG10gWTJX9FVs_IIXmL-I8xVteqfEMOOasqJZhekYefKfrR5RB7GlvaTRiHTcRhY3PwwVHrgqfN9OIjdmGwCPQbDf183NjYDJ4OncWt3WngEPtse4gjdhPdTAOkDD2Ge6DJZqS29_RvwGwT_THFHPfRd-R1azuE90_3Eflz_v332WVxfXNxdfb1unCVULlQbVOqBmqpQShbMQtKCV5zCaX2Vq19VVVSCi209XINrZNzVILQTrkGnCuPyMdFd0jxbgTMZhvQQdctDRupda015zNYL6BLETFBa4YUtjZNhjOzc8DsHTC79Rqtzd4BczvnfXgqMDZb8C-ylpXPwJcFgHnM-wDJoAvQO_AhgcvGx_CfEo8IAZoR</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>Tokumura, Akira</creator><creator>Fujimoto, Hiroaki</creator><creator>Yoshimoto, Osamu</creator><creator>Nishioka, Yuko</creator><creator>Miyake, Maki</creator><creator>Fukuzawa, Kenji</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1999</creationdate><title>Production of lysophosphatidic acid by lysophospholipase D in incubated plasma of spontaneously hypertensive rats and Wistar Kyoto rats</title><author>Tokumura, Akira ; Fujimoto, Hiroaki ; Yoshimoto, Osamu ; Nishioka, Yuko ; Miyake, Maki ; Fukuzawa, Kenji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-7fb37be569e27a40ae7721516e39da78d444662929ad68efc6da76e29c7cbecc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>aging</topic><topic>Aging - metabolism</topic><topic>Animals</topic><topic>Chromatography, Gas</topic><topic>Chromatography, Thin Layer</topic><topic>Fatty Acids - analysis</topic><topic>In Vitro Techniques</topic><topic>lecithin:cholesterol acyltransferase</topic><topic>lysophosphatidic acid</topic><topic>lysophosphatidylcholine</topic><topic>lysophospholipase D</topic><topic>Lysophospholipids - biosynthesis</topic><topic>Lysophospholipids - blood</topic><topic>Lysophospholipids - chemistry</topic><topic>Male</topic><topic>Phosphatidylcholines - blood</topic><topic>Phosphoric Diester Hydrolases - blood</topic><topic>Phosphoric Diester Hydrolases - metabolism</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Rats, Inbred WKY</topic><topic>Species Specificity</topic><topic>spontaneously hypertensive rat</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tokumura, Akira</creatorcontrib><creatorcontrib>Fujimoto, Hiroaki</creatorcontrib><creatorcontrib>Yoshimoto, Osamu</creatorcontrib><creatorcontrib>Nishioka, Yuko</creatorcontrib><creatorcontrib>Miyake, Maki</creatorcontrib><creatorcontrib>Fukuzawa, Kenji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tokumura, Akira</au><au>Fujimoto, Hiroaki</au><au>Yoshimoto, Osamu</au><au>Nishioka, Yuko</au><au>Miyake, Maki</au><au>Fukuzawa, Kenji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Production of lysophosphatidic acid by lysophospholipase D in incubated plasma of spontaneously hypertensive rats and Wistar Kyoto rats</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1999</date><risdate>1999</risdate><volume>65</volume><issue>3</issue><spage>245</spage><epage>253</epage><pages>245-253</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Lysophosphatidic acid has been identified as a vasopressor principle in incubated mammalian plasma and sera, and shown to be generated extracellulary by lysophospholipase D-like activity. In this study, we monitored the time course of changes in the major phospholipid fractions during incubation of plasma, and found that polyunsaturated lysophosphatidic acids accumulate more rapidly than saturated lysophosphatidic acids at expense of the corresponding lysophosphatidylcholines. We compared the phospholipase activities for producing bioactive LPA in age-matched spontaeneously hypertensive rats and Wistar Kyoto rats. The lysophospholipase D activity in rat plasma was found to be independent of strain and age. We suggest that lysophospholipase D functions in rat for persistent production of bioactive LPA in the circulation throughout life. However, our finding that production of LPA in spontaenously hypertensive rats was not greater than that in Wistar Kyoto rats does not seem to support the idea that increased production of LPA is involved in the pathogenesis of hypertension.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>10447209</pmid><doi>10.1016/S0024-3205(99)00243-X</doi><tpages>9</tpages></addata></record> |
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| subjects | aging Aging - metabolism Animals Chromatography, Gas Chromatography, Thin Layer Fatty Acids - analysis In Vitro Techniques lecithin:cholesterol acyltransferase lysophosphatidic acid lysophosphatidylcholine lysophospholipase D Lysophospholipids - biosynthesis Lysophospholipids - blood Lysophospholipids - chemistry Male Phosphatidylcholines - blood Phosphoric Diester Hydrolases - blood Phosphoric Diester Hydrolases - metabolism Rats Rats, Inbred SHR Rats, Inbred WKY Species Specificity spontaneously hypertensive rat Time Factors |
| title | Production of lysophosphatidic acid by lysophospholipase D in incubated plasma of spontaneously hypertensive rats and Wistar Kyoto rats |
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