Correlation of haemostatic abnormalities with tumour stage and characteristics in dogs with mammary carcinoma
Sixty female dogs with untreated mammary carcinoma, comprising equal numbers of dogs in tumour stages I to IV, were evaluated for haemostatic abnormalities using the following tests: platelet count, prothrombin time, activated partial thromboplastin time, thrombin time, plasma activity of factor V,...
Gespeichert in:
| Veröffentlicht in: | Journal of small animal practice 1999-07, Vol.40 (7), p.326-331 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 331 |
|---|---|
| container_issue | 7 |
| container_start_page | 326 |
| container_title | Journal of small animal practice |
| container_volume | 40 |
| creator | Stockhaus, C Kohn, B Rudolph, R Brunnberg, L Giger, U |
| description | Sixty female dogs with untreated mammary carcinoma, comprising equal numbers of dogs in tumour stages I to IV, were evaluated for haemostatic abnormalities using the following tests: platelet count, prothrombin time, activated partial thromboplastin time, thrombin time, plasma activity of factor V, VIII and X, plasma concentration of fibrinogen, fibrin monomers and fibrinogen degradation products, and plasma antithrombin III activity. Two‐thirds of all dogs had one or more haemostatic test abnormality of which the likelihood and frequency was increased in those with stage III and IV neoplasia. Haemostatic abnormalities were more frequently observed in dogs which had mammary tumours with distant metastases, extended tumour necrosis, inflammatory carcinomas, tumours fixed to underlying structures, or tumours in which there was penetration of the tumour capsule by tumour cells. As in humans with mammary carcinoma, these haemostatic abnormalities might be used as prognostic indicators, but their clinical importance remains unknown. |
| doi_str_mv | 10.1111/j.1748-5827.1999.tb03090.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69959521</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69959521</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4336-b35959676169fea37623643269130fb4582fca1d4f0ef73dee6e8691372ca9573</originalsourceid><addsrcrecordid>eNqVkU9vFCEYh4mxsdvqV1DiwduM_BtYvJhmta1No21qozfCMMwu6zBUmEm3375MZtP0Wi6EvM_7g_cBgI8YlTivz9sSC7YsqiURJZZSlkONKJKo3L0Ci6fSa7BAiJCCVRgdgqOUtvnImUBvwCFGjDFRkQXwqxCj7fTgQg9DCzfa-pCGfDZQ132IXnducDbBezds4DD6MEaYgbWFum-g2eiozWCjS7klQdfDJqz3tNfe6_gAjY7G9cHrt-Cg1V2y7_b7Mbg9_f57dV5c_jr7sTq5LAyjlBc1rWQlueCYy9ZqKjihnFHCJaaorVkerzUaN6xFthW0sZbb5VQUxGhZCXoMPs25dzH8H20alHfJ2K7TvQ1jUlzm_IrgDH6ZQRNDStG26i666c0KIzXJVls1GVWTUTXJVnvZapeb3-9vGWtvm2ets90MfJ2Be9fZhxdEq4ubk6s8b04o5oSs1-6eEnT8p7igolJ_fp6p66vT69U3-VedZ_7DzLc6KL3Ov6JubwjK2ojMGllFHwFl6Kl5</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69959521</pqid></control><display><type>article</type><title>Correlation of haemostatic abnormalities with tumour stage and characteristics in dogs with mammary carcinoma</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Stockhaus, C ; Kohn, B ; Rudolph, R ; Brunnberg, L ; Giger, U</creator><creatorcontrib>Stockhaus, C ; Kohn, B ; Rudolph, R ; Brunnberg, L ; Giger, U</creatorcontrib><description>Sixty female dogs with untreated mammary carcinoma, comprising equal numbers of dogs in tumour stages I to IV, were evaluated for haemostatic abnormalities using the following tests: platelet count, prothrombin time, activated partial thromboplastin time, thrombin time, plasma activity of factor V, VIII and X, plasma concentration of fibrinogen, fibrin monomers and fibrinogen degradation products, and plasma antithrombin III activity. Two‐thirds of all dogs had one or more haemostatic test abnormality of which the likelihood and frequency was increased in those with stage III and IV neoplasia. Haemostatic abnormalities were more frequently observed in dogs which had mammary tumours with distant metastases, extended tumour necrosis, inflammatory carcinomas, tumours fixed to underlying structures, or tumours in which there was penetration of the tumour capsule by tumour cells. As in humans with mammary carcinoma, these haemostatic abnormalities might be used as prognostic indicators, but their clinical importance remains unknown.</description><identifier>ISSN: 0022-4510</identifier><identifier>EISSN: 1748-5827</identifier><identifier>DOI: 10.1111/j.1748-5827.1999.tb03090.x</identifier><identifier>PMID: 10444752</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>abnormal development ; Adenocarcinoma - blood ; Adenocarcinoma - pathology ; Adenocarcinoma - veterinary ; Animals ; Blood Coagulation Factors - isolation & purification ; Blood Coagulation Tests ; Carcinoma - blood ; Carcinoma - pathology ; Carcinoma - veterinary ; characteristics ; disease course ; Dog Diseases - blood ; Dog Diseases - pathology ; Dogs ; Female ; females ; Hemostasis ; incidence ; mammary neoplasms (animal) ; Mammary Neoplasms, Animal - blood ; Mammary Neoplasms, Animal - pathology ; Neoplasm Staging - veterinary ; Reference Values ; Risk</subject><ispartof>Journal of small animal practice, 1999-07, Vol.40 (7), p.326-331</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4336-b35959676169fea37623643269130fb4582fca1d4f0ef73dee6e8691372ca9573</citedby><cites>FETCH-LOGICAL-c4336-b35959676169fea37623643269130fb4582fca1d4f0ef73dee6e8691372ca9573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1748-5827.1999.tb03090.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1748-5827.1999.tb03090.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10444752$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stockhaus, C</creatorcontrib><creatorcontrib>Kohn, B</creatorcontrib><creatorcontrib>Rudolph, R</creatorcontrib><creatorcontrib>Brunnberg, L</creatorcontrib><creatorcontrib>Giger, U</creatorcontrib><title>Correlation of haemostatic abnormalities with tumour stage and characteristics in dogs with mammary carcinoma</title><title>Journal of small animal practice</title><addtitle>J Small Anim Pract</addtitle><description>Sixty female dogs with untreated mammary carcinoma, comprising equal numbers of dogs in tumour stages I to IV, were evaluated for haemostatic abnormalities using the following tests: platelet count, prothrombin time, activated partial thromboplastin time, thrombin time, plasma activity of factor V, VIII and X, plasma concentration of fibrinogen, fibrin monomers and fibrinogen degradation products, and plasma antithrombin III activity. Two‐thirds of all dogs had one or more haemostatic test abnormality of which the likelihood and frequency was increased in those with stage III and IV neoplasia. Haemostatic abnormalities were more frequently observed in dogs which had mammary tumours with distant metastases, extended tumour necrosis, inflammatory carcinomas, tumours fixed to underlying structures, or tumours in which there was penetration of the tumour capsule by tumour cells. As in humans with mammary carcinoma, these haemostatic abnormalities might be used as prognostic indicators, but their clinical importance remains unknown.</description><subject>abnormal development</subject><subject>Adenocarcinoma - blood</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - veterinary</subject><subject>Animals</subject><subject>Blood Coagulation Factors - isolation & purification</subject><subject>Blood Coagulation Tests</subject><subject>Carcinoma - blood</subject><subject>Carcinoma - pathology</subject><subject>Carcinoma - veterinary</subject><subject>characteristics</subject><subject>disease course</subject><subject>Dog Diseases - blood</subject><subject>Dog Diseases - pathology</subject><subject>Dogs</subject><subject>Female</subject><subject>females</subject><subject>Hemostasis</subject><subject>incidence</subject><subject>mammary neoplasms (animal)</subject><subject>Mammary Neoplasms, Animal - blood</subject><subject>Mammary Neoplasms, Animal - pathology</subject><subject>Neoplasm Staging - veterinary</subject><subject>Reference Values</subject><subject>Risk</subject><issn>0022-4510</issn><issn>1748-5827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkU9vFCEYh4mxsdvqV1DiwduM_BtYvJhmta1No21qozfCMMwu6zBUmEm3375MZtP0Wi6EvM_7g_cBgI8YlTivz9sSC7YsqiURJZZSlkONKJKo3L0Ci6fSa7BAiJCCVRgdgqOUtvnImUBvwCFGjDFRkQXwqxCj7fTgQg9DCzfa-pCGfDZQ132IXnducDbBezds4DD6MEaYgbWFum-g2eiozWCjS7klQdfDJqz3tNfe6_gAjY7G9cHrt-Cg1V2y7_b7Mbg9_f57dV5c_jr7sTq5LAyjlBc1rWQlueCYy9ZqKjihnFHCJaaorVkerzUaN6xFthW0sZbb5VQUxGhZCXoMPs25dzH8H20alHfJ2K7TvQ1jUlzm_IrgDH6ZQRNDStG26i666c0KIzXJVls1GVWTUTXJVnvZapeb3-9vGWtvm2ets90MfJ2Be9fZhxdEq4ubk6s8b04o5oSs1-6eEnT8p7igolJ_fp6p66vT69U3-VedZ_7DzLc6KL3Ov6JubwjK2ojMGllFHwFl6Kl5</recordid><startdate>199907</startdate><enddate>199907</enddate><creator>Stockhaus, C</creator><creator>Kohn, B</creator><creator>Rudolph, R</creator><creator>Brunnberg, L</creator><creator>Giger, U</creator><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199907</creationdate><title>Correlation of haemostatic abnormalities with tumour stage and characteristics in dogs with mammary carcinoma</title><author>Stockhaus, C ; Kohn, B ; Rudolph, R ; Brunnberg, L ; Giger, U</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4336-b35959676169fea37623643269130fb4582fca1d4f0ef73dee6e8691372ca9573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>abnormal development</topic><topic>Adenocarcinoma - blood</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - veterinary</topic><topic>Animals</topic><topic>Blood Coagulation Factors - isolation & purification</topic><topic>Blood Coagulation Tests</topic><topic>Carcinoma - blood</topic><topic>Carcinoma - pathology</topic><topic>Carcinoma - veterinary</topic><topic>characteristics</topic><topic>disease course</topic><topic>Dog Diseases - blood</topic><topic>Dog Diseases - pathology</topic><topic>Dogs</topic><topic>Female</topic><topic>females</topic><topic>Hemostasis</topic><topic>incidence</topic><topic>mammary neoplasms (animal)</topic><topic>Mammary Neoplasms, Animal - blood</topic><topic>Mammary Neoplasms, Animal - pathology</topic><topic>Neoplasm Staging - veterinary</topic><topic>Reference Values</topic><topic>Risk</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stockhaus, C</creatorcontrib><creatorcontrib>Kohn, B</creatorcontrib><creatorcontrib>Rudolph, R</creatorcontrib><creatorcontrib>Brunnberg, L</creatorcontrib><creatorcontrib>Giger, U</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of small animal practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stockhaus, C</au><au>Kohn, B</au><au>Rudolph, R</au><au>Brunnberg, L</au><au>Giger, U</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of haemostatic abnormalities with tumour stage and characteristics in dogs with mammary carcinoma</atitle><jtitle>Journal of small animal practice</jtitle><addtitle>J Small Anim Pract</addtitle><date>1999-07</date><risdate>1999</risdate><volume>40</volume><issue>7</issue><spage>326</spage><epage>331</epage><pages>326-331</pages><issn>0022-4510</issn><eissn>1748-5827</eissn><abstract>Sixty female dogs with untreated mammary carcinoma, comprising equal numbers of dogs in tumour stages I to IV, were evaluated for haemostatic abnormalities using the following tests: platelet count, prothrombin time, activated partial thromboplastin time, thrombin time, plasma activity of factor V, VIII and X, plasma concentration of fibrinogen, fibrin monomers and fibrinogen degradation products, and plasma antithrombin III activity. Two‐thirds of all dogs had one or more haemostatic test abnormality of which the likelihood and frequency was increased in those with stage III and IV neoplasia. Haemostatic abnormalities were more frequently observed in dogs which had mammary tumours with distant metastases, extended tumour necrosis, inflammatory carcinomas, tumours fixed to underlying structures, or tumours in which there was penetration of the tumour capsule by tumour cells. As in humans with mammary carcinoma, these haemostatic abnormalities might be used as prognostic indicators, but their clinical importance remains unknown.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>10444752</pmid><doi>10.1111/j.1748-5827.1999.tb03090.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-4510 |
| ispartof | Journal of small animal practice, 1999-07, Vol.40 (7), p.326-331 |
| issn | 0022-4510 1748-5827 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69959521 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | abnormal development Adenocarcinoma - blood Adenocarcinoma - pathology Adenocarcinoma - veterinary Animals Blood Coagulation Factors - isolation & purification Blood Coagulation Tests Carcinoma - blood Carcinoma - pathology Carcinoma - veterinary characteristics disease course Dog Diseases - blood Dog Diseases - pathology Dogs Female females Hemostasis incidence mammary neoplasms (animal) Mammary Neoplasms, Animal - blood Mammary Neoplasms, Animal - pathology Neoplasm Staging - veterinary Reference Values Risk |
| title | Correlation of haemostatic abnormalities with tumour stage and characteristics in dogs with mammary carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T00%3A14%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Correlation%20of%20haemostatic%20abnormalities%20with%20tumour%20stage%20and%20characteristics%20in%20dogs%20with%20mammary%20carcinoma&rft.jtitle=Journal%20of%20small%20animal%20practice&rft.au=Stockhaus,%20C&rft.date=1999-07&rft.volume=40&rft.issue=7&rft.spage=326&rft.epage=331&rft.pages=326-331&rft.issn=0022-4510&rft.eissn=1748-5827&rft_id=info:doi/10.1111/j.1748-5827.1999.tb03090.x&rft_dat=%3Cproquest_cross%3E69959521%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69959521&rft_id=info:pmid/10444752&rfr_iscdi=true |