Ascaris-specific IgE and allergic sensitization in a cohort of school children in the former East Germany
Background: Helminthic infections induce an IL-4–dependent polyclonal stimulation of IgE synthetization. It is still unclear, however, what role helminths play in allergic sensitization. Objective: We sought to determine the relationship between Ascaris-specific IgE and allergic sensitization in a n...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 1998-09, Vol.102 (3), p.414-420 |
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| description | Background: Helminthic infections induce an IL-4–dependent polyclonal stimulation of IgE synthetization. It is still unclear, however, what role helminths play in allergic sensitization.
Objective: We sought to determine the relationship between
Ascaris-specific IgE and allergic sensitization in a nontropical country.
Methods: In 2 consecutive cross-sectional surveys in 1992-1993 and 1995-1996, data from school entrants (age range, 5 to 7 years), third graders (age range, 8 to 10 years), and sixth graders (age range, 11 to 14 years) were collected. The 2 younger groups were reexamined in the second survey. Data for about 2300 children, including a cohort of 700 subjects, were analyzed.
Ascaris IgE and total and specific IgE to inhalant allergens were measured, and skin prick tests were performed. Information about asthma and allergic rhinitis was collected by a questionnaire.
Results: Children who were
Ascaris-IgE seropositive (>0.35 IU/mL) in both surveys had 10-fold higher levels of total IgE (451 IU/mL vs 45 IU/mL,
P < .001) and higher prevalence rates of allergen-specific IgE seropositivity (56.3% vs 26.6%,
P < .001). They also had a higher prevalence of allergic rhinitis (12.6% vs 3.7%,
P < .001) and asthma (5.7% vs 1.6%,
P < .05). In subjects who were
Ascaris-seronegative in the first survey but seropositive in the second survey, total and specific IgE increased markedly. Sensitization to
Dermatophagoides pteronyssinus increased nearly 3-fold in this group. In contrast, in children who became
Ascaris-seronegative, total and specific IgE decreased.
Conclusions: Contact with low doses of helminthic antigen is associated with an increase of total and specific IgE production. Helminthic infections in East German children are not the cause for a low prevalence of allergies in the former East Germany. (J Allergy Clin Immunol 1998;102:414-20.) |
| doi_str_mv | 10.1016/S0091-6749(98)70129-0 |
| format | Article |
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Objective: We sought to determine the relationship between
Ascaris-specific IgE and allergic sensitization in a nontropical country.
Methods: In 2 consecutive cross-sectional surveys in 1992-1993 and 1995-1996, data from school entrants (age range, 5 to 7 years), third graders (age range, 8 to 10 years), and sixth graders (age range, 11 to 14 years) were collected. The 2 younger groups were reexamined in the second survey. Data for about 2300 children, including a cohort of 700 subjects, were analyzed.
Ascaris IgE and total and specific IgE to inhalant allergens were measured, and skin prick tests were performed. Information about asthma and allergic rhinitis was collected by a questionnaire.
Results: Children who were
Ascaris-IgE seropositive (>0.35 IU/mL) in both surveys had 10-fold higher levels of total IgE (451 IU/mL vs 45 IU/mL,
P < .001) and higher prevalence rates of allergen-specific IgE seropositivity (56.3% vs 26.6%,
P < .001). They also had a higher prevalence of allergic rhinitis (12.6% vs 3.7%,
P < .001) and asthma (5.7% vs 1.6%,
P < .05). In subjects who were
Ascaris-seronegative in the first survey but seropositive in the second survey, total and specific IgE increased markedly. Sensitization to
Dermatophagoides pteronyssinus increased nearly 3-fold in this group. In contrast, in children who became
Ascaris-seronegative, total and specific IgE decreased.
Conclusions: Contact with low doses of helminthic antigen is associated with an increase of total and specific IgE production. Helminthic infections in East German children are not the cause for a low prevalence of allergies in the former East Germany. (J Allergy Clin Immunol 1998;102:414-20.)</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/S0091-6749(98)70129-0</identifier><identifier>PMID: 9768582</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adolescent ; Allergy ; Animals ; Antibodies, Helminth - blood ; Antibody Specificity ; Antigens, Helminth - immunology ; Ascariasis ; Ascariasis - blood ; Ascariasis - immunology ; Ascaris ; Ascaris - immunology ; asthma ; Biological and medical sciences ; Child ; Child, Preschool ; Cohort Studies ; Cross-Sectional Studies ; Diseases caused by nematodes ; Female ; Germany, East ; Helminthic diseases ; helminthic infection ; Humans ; Hypersensitivity - blood ; Hypersensitivity - immunology ; Hypersensitivity - parasitology ; IgE ; Immunization ; Immunoglobulin E - blood ; Immunoglobulin E - immunology ; Infectious diseases ; Male ; Medical sciences ; parasites ; Parasitic diseases ; Radioallergosorbent Test ; Skin Tests</subject><ispartof>Journal of allergy and clinical immunology, 1998-09, Vol.102 (3), p.414-420</ispartof><rights>1998 Mosby, Inc.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-e1e7eca0bf2afa3bb3fb4194036c26b5b32f48ec1c8f00ddc03a0e26d66c8f563</citedby><cites>FETCH-LOGICAL-c517t-e1e7eca0bf2afa3bb3fb4194036c26b5b32f48ec1c8f00ddc03a0e26d66c8f563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0091-6749(98)70129-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2425441$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9768582$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dold, Sigrid</creatorcontrib><creatorcontrib>Heinrich, Joachim</creatorcontrib><creatorcontrib>Wichmann, Heinz-Erich</creatorcontrib><creatorcontrib>Wjst, Matthias</creatorcontrib><title>Ascaris-specific IgE and allergic sensitization in a cohort of school children in the former East Germany</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Background: Helminthic infections induce an IL-4–dependent polyclonal stimulation of IgE synthetization. It is still unclear, however, what role helminths play in allergic sensitization.
Objective: We sought to determine the relationship between
Ascaris-specific IgE and allergic sensitization in a nontropical country.
Methods: In 2 consecutive cross-sectional surveys in 1992-1993 and 1995-1996, data from school entrants (age range, 5 to 7 years), third graders (age range, 8 to 10 years), and sixth graders (age range, 11 to 14 years) were collected. The 2 younger groups were reexamined in the second survey. Data for about 2300 children, including a cohort of 700 subjects, were analyzed.
Ascaris IgE and total and specific IgE to inhalant allergens were measured, and skin prick tests were performed. Information about asthma and allergic rhinitis was collected by a questionnaire.
Results: Children who were
Ascaris-IgE seropositive (>0.35 IU/mL) in both surveys had 10-fold higher levels of total IgE (451 IU/mL vs 45 IU/mL,
P < .001) and higher prevalence rates of allergen-specific IgE seropositivity (56.3% vs 26.6%,
P < .001). They also had a higher prevalence of allergic rhinitis (12.6% vs 3.7%,
P < .001) and asthma (5.7% vs 1.6%,
P < .05). In subjects who were
Ascaris-seronegative in the first survey but seropositive in the second survey, total and specific IgE increased markedly. Sensitization to
Dermatophagoides pteronyssinus increased nearly 3-fold in this group. In contrast, in children who became
Ascaris-seronegative, total and specific IgE decreased.
Conclusions: Contact with low doses of helminthic antigen is associated with an increase of total and specific IgE production. Helminthic infections in East German children are not the cause for a low prevalence of allergies in the former East Germany. (J Allergy Clin Immunol 1998;102:414-20.)</description><subject>Adolescent</subject><subject>Allergy</subject><subject>Animals</subject><subject>Antibodies, Helminth - blood</subject><subject>Antibody Specificity</subject><subject>Antigens, Helminth - immunology</subject><subject>Ascariasis</subject><subject>Ascariasis - blood</subject><subject>Ascariasis - immunology</subject><subject>Ascaris</subject><subject>Ascaris - immunology</subject><subject>asthma</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Diseases caused by nematodes</subject><subject>Female</subject><subject>Germany, East</subject><subject>Helminthic diseases</subject><subject>helminthic infection</subject><subject>Humans</subject><subject>Hypersensitivity - blood</subject><subject>Hypersensitivity - immunology</subject><subject>Hypersensitivity - parasitology</subject><subject>IgE</subject><subject>Immunization</subject><subject>Immunoglobulin E - blood</subject><subject>Immunoglobulin E - immunology</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>parasites</subject><subject>Parasitic diseases</subject><subject>Radioallergosorbent Test</subject><subject>Skin Tests</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9r3DAQxUVJSTdpP0JAhxKag1NJtiXrFELYJoFAD23PQh6Psiq2tdF4A-mnr_cPe81pmHm_GYn3GLuQ4loKqb__EsLKQpvKfrPNlRFS2UJ8YAsprCl0o-oTtjgin9gZ0V8x92VjT9mpNbqpG7Vg8ZbA50gFrRFiiMAfn5fcjx33fY_5eR4QjhSn-M9PMY08jtxzSKuUJ54CJ1il1HNYxb7LuJOnFfKQ8oCZLz1N_B7z4Me3z-xj8D3hl0M9Z39-LH_fPRRPP-8f726fCqilmQqUaBC8aIPywZdtW4a2krYSpQal27otVagaBAlNEKLrQJReoNKd1vOk1uU5u9zfXef0skGa3BAJsO_9iGlDTltbGyntu6A0ypjSbC_WexByIsoY3DrHwec3J4XbZuF2Wbit0c42bpeFE_PexeGBTTtgd9w6mD_rXw-6n0PoQ_YjRDpiqlJ1VckZu9ljOLv2GjE7gogjYBczwuS6FN_5yH_Xb6bd</recordid><startdate>19980901</startdate><enddate>19980901</enddate><creator>Dold, Sigrid</creator><creator>Heinrich, Joachim</creator><creator>Wichmann, Heinz-Erich</creator><creator>Wjst, Matthias</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19980901</creationdate><title>Ascaris-specific IgE and allergic sensitization in a cohort of school children in the former East Germany</title><author>Dold, Sigrid ; Heinrich, Joachim ; Wichmann, Heinz-Erich ; Wjst, Matthias</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-e1e7eca0bf2afa3bb3fb4194036c26b5b32f48ec1c8f00ddc03a0e26d66c8f563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adolescent</topic><topic>Allergy</topic><topic>Animals</topic><topic>Antibodies, Helminth - blood</topic><topic>Antibody Specificity</topic><topic>Antigens, Helminth - immunology</topic><topic>Ascariasis</topic><topic>Ascariasis - blood</topic><topic>Ascariasis - immunology</topic><topic>Ascaris</topic><topic>Ascaris - immunology</topic><topic>asthma</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Diseases caused by nematodes</topic><topic>Female</topic><topic>Germany, East</topic><topic>Helminthic diseases</topic><topic>helminthic infection</topic><topic>Humans</topic><topic>Hypersensitivity - blood</topic><topic>Hypersensitivity - immunology</topic><topic>Hypersensitivity - parasitology</topic><topic>IgE</topic><topic>Immunization</topic><topic>Immunoglobulin E - blood</topic><topic>Immunoglobulin E - immunology</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>parasites</topic><topic>Parasitic diseases</topic><topic>Radioallergosorbent Test</topic><topic>Skin Tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dold, Sigrid</creatorcontrib><creatorcontrib>Heinrich, Joachim</creatorcontrib><creatorcontrib>Wichmann, Heinz-Erich</creatorcontrib><creatorcontrib>Wjst, Matthias</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dold, Sigrid</au><au>Heinrich, Joachim</au><au>Wichmann, Heinz-Erich</au><au>Wjst, Matthias</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ascaris-specific IgE and allergic sensitization in a cohort of school children in the former East Germany</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>1998-09-01</date><risdate>1998</risdate><volume>102</volume><issue>3</issue><spage>414</spage><epage>420</epage><pages>414-420</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>Background: Helminthic infections induce an IL-4–dependent polyclonal stimulation of IgE synthetization. It is still unclear, however, what role helminths play in allergic sensitization.
Objective: We sought to determine the relationship between
Ascaris-specific IgE and allergic sensitization in a nontropical country.
Methods: In 2 consecutive cross-sectional surveys in 1992-1993 and 1995-1996, data from school entrants (age range, 5 to 7 years), third graders (age range, 8 to 10 years), and sixth graders (age range, 11 to 14 years) were collected. The 2 younger groups were reexamined in the second survey. Data for about 2300 children, including a cohort of 700 subjects, were analyzed.
Ascaris IgE and total and specific IgE to inhalant allergens were measured, and skin prick tests were performed. Information about asthma and allergic rhinitis was collected by a questionnaire.
Results: Children who were
Ascaris-IgE seropositive (>0.35 IU/mL) in both surveys had 10-fold higher levels of total IgE (451 IU/mL vs 45 IU/mL,
P < .001) and higher prevalence rates of allergen-specific IgE seropositivity (56.3% vs 26.6%,
P < .001). They also had a higher prevalence of allergic rhinitis (12.6% vs 3.7%,
P < .001) and asthma (5.7% vs 1.6%,
P < .05). In subjects who were
Ascaris-seronegative in the first survey but seropositive in the second survey, total and specific IgE increased markedly. Sensitization to
Dermatophagoides pteronyssinus increased nearly 3-fold in this group. In contrast, in children who became
Ascaris-seronegative, total and specific IgE decreased.
Conclusions: Contact with low doses of helminthic antigen is associated with an increase of total and specific IgE production. Helminthic infections in East German children are not the cause for a low prevalence of allergies in the former East Germany. (J Allergy Clin Immunol 1998;102:414-20.)</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>9768582</pmid><doi>10.1016/S0091-6749(98)70129-0</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Allergy Animals Antibodies, Helminth - blood Antibody Specificity Antigens, Helminth - immunology Ascariasis Ascariasis - blood Ascariasis - immunology Ascaris Ascaris - immunology asthma Biological and medical sciences Child Child, Preschool Cohort Studies Cross-Sectional Studies Diseases caused by nematodes Female Germany, East Helminthic diseases helminthic infection Humans Hypersensitivity - blood Hypersensitivity - immunology Hypersensitivity - parasitology IgE Immunization Immunoglobulin E - blood Immunoglobulin E - immunology Infectious diseases Male Medical sciences parasites Parasitic diseases Radioallergosorbent Test Skin Tests |
| title | Ascaris-specific IgE and allergic sensitization in a cohort of school children in the former East Germany |
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