Nitric oxide modulates the release of serotonin in the rat hypothalamus
To investigate the effect of nitric oxide (NO) on the release of serotonin and its main metabolite, 5-hydroxyindoleacetic acid (5-HIAA), the posterior hypothalamus of the conscious rat was superfused through a push–pull cannula with drugs which either liberate NO, or inhibit NO synthase (NOS). The N...
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| Veröffentlicht in: | Brain research 1999-07, Vol.835 (2), p.346-349 |
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| description | To investigate the effect of nitric oxide (NO) on the release of serotonin and its main metabolite, 5-hydroxyindoleacetic acid (5-HIAA), the posterior hypothalamus of the conscious rat was superfused through a push–pull cannula with drugs which either liberate NO, or inhibit NO synthase (NOS). The NO donors, linsidomine, diethylamine/nitric oxide (DEA/NO),
S-nitroso-
N-acetylpenicillamine (SNAP),
S-nitroso-glutathione (SNOG) and sodium nitroprusside influenced the release of serotonin in a biphasic way. Low concentrations of drugs diminished, while higher concentrations of these compounds enhanced the outflow of serotonin. The NOS inhibitors
N
G-methyl-
l-arginine methyl ester (
l-NAME) and 7-nitroindazole (7-NINA) enhanced the serotonin release. A high concentration of
l-NAME slightly diminished the outflow of serotonin. Inhibition of the guanylyl cyclase by oxodiazolo[4,3]quinoxaline-one (ODQ) abolished the changes in serotonin outflow induced by both low and high concentrations of linsidomine. The extracellular concentration of the 5-HIAA was not influenced by the compounds used. These data suggest that endogenous NO modulates the release of serotonin in a biphasic and cGMP-dependent way. |
| doi_str_mv | 10.1016/S0006-8993(99)01599-1 |
| format | Article |
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S-nitroso-
N-acetylpenicillamine (SNAP),
S-nitroso-glutathione (SNOG) and sodium nitroprusside influenced the release of serotonin in a biphasic way. Low concentrations of drugs diminished, while higher concentrations of these compounds enhanced the outflow of serotonin. The NOS inhibitors
N
G-methyl-
l-arginine methyl ester (
l-NAME) and 7-nitroindazole (7-NINA) enhanced the serotonin release. A high concentration of
l-NAME slightly diminished the outflow of serotonin. Inhibition of the guanylyl cyclase by oxodiazolo[4,3]quinoxaline-one (ODQ) abolished the changes in serotonin outflow induced by both low and high concentrations of linsidomine. The extracellular concentration of the 5-HIAA was not influenced by the compounds used. These data suggest that endogenous NO modulates the release of serotonin in a biphasic and cGMP-dependent way.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(99)01599-1</identifier><identifier>PMID: 10415393</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>7-Nitroindazole ; Animals ; Biological and medical sciences ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Enzyme Inhibitors - pharmacology ; Fundamental and applied biological sciences. Psychology ; Glutathione - analogs & derivatives ; Glutathione - pharmacology ; Guanylate Cyclase - antagonists & inhibitors ; Hydroxyindoleacetic Acid - metabolism ; Hypothalamus, Posterior - drug effects ; Hypothalamus, Posterior - metabolism ; Indazoles - pharmacology ; l-NAME ; Linsidomine ; Male ; NG-Nitroarginine Methyl Ester - pharmacology ; Nitric oxide (NO) ; Nitric Oxide - pharmacology ; Nitric Oxide Synthase - biosynthesis ; Nitroprusside - pharmacology ; Nitroso Compounds - pharmacology ; Penicillamine - analogs & derivatives ; Penicillamine - pharmacology ; Push–pull superfusion ; Rats ; Rats, Sprague-Dawley ; S-Nitrosoglutathione ; Serotonin - metabolism ; SNAP ; SNOG ; Sodium nitroprusside ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 1999-07, Vol.835 (2), p.346-349</ispartof><rights>1999 Elsevier Science B.V.</rights><rights>1999 INIST-CNRS</rights><rights>Copyright 1999 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-c20d5938d35ad5a5383b6a45d395ac49b36ec19bb718378524d9102680d5d20d3</citedby><cites>FETCH-LOGICAL-c421t-c20d5938d35ad5a5383b6a45d395ac49b36ec19bb718378524d9102680d5d20d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0006-8993(99)01599-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1911197$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10415393$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaehler, Stefan T.</creatorcontrib><creatorcontrib>Singewald, Nicolas</creatorcontrib><creatorcontrib>Sinner, Catrin</creatorcontrib><creatorcontrib>Philippu, Athineos</creatorcontrib><title>Nitric oxide modulates the release of serotonin in the rat hypothalamus</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>To investigate the effect of nitric oxide (NO) on the release of serotonin and its main metabolite, 5-hydroxyindoleacetic acid (5-HIAA), the posterior hypothalamus of the conscious rat was superfused through a push–pull cannula with drugs which either liberate NO, or inhibit NO synthase (NOS). The NO donors, linsidomine, diethylamine/nitric oxide (DEA/NO),
S-nitroso-
N-acetylpenicillamine (SNAP),
S-nitroso-glutathione (SNOG) and sodium nitroprusside influenced the release of serotonin in a biphasic way. Low concentrations of drugs diminished, while higher concentrations of these compounds enhanced the outflow of serotonin. The NOS inhibitors
N
G-methyl-
l-arginine methyl ester (
l-NAME) and 7-nitroindazole (7-NINA) enhanced the serotonin release. A high concentration of
l-NAME slightly diminished the outflow of serotonin. Inhibition of the guanylyl cyclase by oxodiazolo[4,3]quinoxaline-one (ODQ) abolished the changes in serotonin outflow induced by both low and high concentrations of linsidomine. The extracellular concentration of the 5-HIAA was not influenced by the compounds used. These data suggest that endogenous NO modulates the release of serotonin in a biphasic and cGMP-dependent way.</description><subject>7-Nitroindazole</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glutathione - analogs & derivatives</subject><subject>Glutathione - pharmacology</subject><subject>Guanylate Cyclase - antagonists & inhibitors</subject><subject>Hydroxyindoleacetic Acid - metabolism</subject><subject>Hypothalamus, Posterior - drug effects</subject><subject>Hypothalamus, Posterior - metabolism</subject><subject>Indazoles - pharmacology</subject><subject>l-NAME</subject><subject>Linsidomine</subject><subject>Male</subject><subject>NG-Nitroarginine Methyl Ester - pharmacology</subject><subject>Nitric oxide (NO)</subject><subject>Nitric Oxide - pharmacology</subject><subject>Nitric Oxide Synthase - biosynthesis</subject><subject>Nitroprusside - pharmacology</subject><subject>Nitroso Compounds - pharmacology</subject><subject>Penicillamine - analogs & derivatives</subject><subject>Penicillamine - pharmacology</subject><subject>Push–pull superfusion</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>S-Nitrosoglutathione</subject><subject>Serotonin - metabolism</subject><subject>SNAP</subject><subject>SNOG</subject><subject>Sodium nitroprusside</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rFTEUQENR7LP6EyqzENHFaO5kkpm7EilahWIXbdchk9zHS5mZPJOM2H9v3gfWXSEQQs7JDYexc-AfgYP6dMM5V3WPKN4jfuAgEWs4YSvou6ZWTcufsdU_5JS9TOm-HIVA_oKdAm9BChQrdvnT5-htFf54R9UU3DKaTKnKG6oijWQSVWFdJYohh9nPVVn7O5OrzcM25I0ZzbSkV-z52oyJXh_3M3b37evtxff66vryx8WXq9q2DeTaNtxJFL0T0jhppOjFoEwrnUBpbIuDUGQBh6GDXnS9bFqHwBvVF80VV5yxd4d3tzH8WihlPflkaRzNTGFJWiFKVZQnQegEx15BAeUBtDGkFGmtt9FPJj5o4HqXWu9T611Hjaj3qfXOe3McsAwTuf-sQ9sCvD0CJlkzrqOZrU-PHAIAdgX7fMCoZPvtKepkPc2WnI9ks3bBP_GTv7O8mYY</recordid><startdate>19990724</startdate><enddate>19990724</enddate><creator>Kaehler, Stefan T.</creator><creator>Singewald, Nicolas</creator><creator>Sinner, Catrin</creator><creator>Philippu, Athineos</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19990724</creationdate><title>Nitric oxide modulates the release of serotonin in the rat hypothalamus</title><author>Kaehler, Stefan T. ; Singewald, Nicolas ; Sinner, Catrin ; Philippu, Athineos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-c20d5938d35ad5a5383b6a45d395ac49b36ec19bb718378524d9102680d5d20d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>7-Nitroindazole</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glutathione - analogs & derivatives</topic><topic>Glutathione - pharmacology</topic><topic>Guanylate Cyclase - antagonists & inhibitors</topic><topic>Hydroxyindoleacetic Acid - metabolism</topic><topic>Hypothalamus, Posterior - drug effects</topic><topic>Hypothalamus, Posterior - metabolism</topic><topic>Indazoles - pharmacology</topic><topic>l-NAME</topic><topic>Linsidomine</topic><topic>Male</topic><topic>NG-Nitroarginine Methyl Ester - pharmacology</topic><topic>Nitric oxide (NO)</topic><topic>Nitric Oxide - pharmacology</topic><topic>Nitric Oxide Synthase - biosynthesis</topic><topic>Nitroprusside - pharmacology</topic><topic>Nitroso Compounds - pharmacology</topic><topic>Penicillamine - analogs & derivatives</topic><topic>Penicillamine - pharmacology</topic><topic>Push–pull superfusion</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>S-Nitrosoglutathione</topic><topic>Serotonin - metabolism</topic><topic>SNAP</topic><topic>SNOG</topic><topic>Sodium nitroprusside</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaehler, Stefan T.</creatorcontrib><creatorcontrib>Singewald, Nicolas</creatorcontrib><creatorcontrib>Sinner, Catrin</creatorcontrib><creatorcontrib>Philippu, Athineos</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaehler, Stefan T.</au><au>Singewald, Nicolas</au><au>Sinner, Catrin</au><au>Philippu, Athineos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nitric oxide modulates the release of serotonin in the rat hypothalamus</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1999-07-24</date><risdate>1999</risdate><volume>835</volume><issue>2</issue><spage>346</spage><epage>349</epage><pages>346-349</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>To investigate the effect of nitric oxide (NO) on the release of serotonin and its main metabolite, 5-hydroxyindoleacetic acid (5-HIAA), the posterior hypothalamus of the conscious rat was superfused through a push–pull cannula with drugs which either liberate NO, or inhibit NO synthase (NOS). The NO donors, linsidomine, diethylamine/nitric oxide (DEA/NO),
S-nitroso-
N-acetylpenicillamine (SNAP),
S-nitroso-glutathione (SNOG) and sodium nitroprusside influenced the release of serotonin in a biphasic way. Low concentrations of drugs diminished, while higher concentrations of these compounds enhanced the outflow of serotonin. The NOS inhibitors
N
G-methyl-
l-arginine methyl ester (
l-NAME) and 7-nitroindazole (7-NINA) enhanced the serotonin release. A high concentration of
l-NAME slightly diminished the outflow of serotonin. Inhibition of the guanylyl cyclase by oxodiazolo[4,3]quinoxaline-one (ODQ) abolished the changes in serotonin outflow induced by both low and high concentrations of linsidomine. The extracellular concentration of the 5-HIAA was not influenced by the compounds used. These data suggest that endogenous NO modulates the release of serotonin in a biphasic and cGMP-dependent way.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>10415393</pmid><doi>10.1016/S0006-8993(99)01599-1</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Brain research, 1999-07, Vol.835 (2), p.346-349 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | 7-Nitroindazole Animals Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Glutathione - analogs & derivatives Glutathione - pharmacology Guanylate Cyclase - antagonists & inhibitors Hydroxyindoleacetic Acid - metabolism Hypothalamus, Posterior - drug effects Hypothalamus, Posterior - metabolism Indazoles - pharmacology l-NAME Linsidomine Male NG-Nitroarginine Methyl Ester - pharmacology Nitric oxide (NO) Nitric Oxide - pharmacology Nitric Oxide Synthase - biosynthesis Nitroprusside - pharmacology Nitroso Compounds - pharmacology Penicillamine - analogs & derivatives Penicillamine - pharmacology Push–pull superfusion Rats Rats, Sprague-Dawley S-Nitrosoglutathione Serotonin - metabolism SNAP SNOG Sodium nitroprusside Vertebrates: nervous system and sense organs |
| title | Nitric oxide modulates the release of serotonin in the rat hypothalamus |
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