An increase in [ [formula omitted]] CGS21680 binding in the striatum of postmortem brains of chronic schizophrenics
We measured adenosine 2a receptors in basal ganglia of 13 schizophrenics and 10 controls, using [ 3 H ] CGS21680 as a ligand for the receptor binding assay. There was a significant increase in the specific [ 3 H ] CGS21680 binding in the putamen and caudate, but not in the globus pallidus of externa...
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| Veröffentlicht in: | Brain research 1998-10, Vol.808 (2), p.320-323 |
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| container_title | Brain research |
| container_volume | 808 |
| creator | Kurumaji, Akeo Toru, Michio |
| description | We measured adenosine 2a receptors in basal ganglia of 13 schizophrenics and 10 controls, using [
3
H
] CGS21680 as a ligand for the receptor binding assay. There was a significant increase in the specific [
3
H
] CGS21680 binding in the putamen and caudate, but not in the globus pallidus of externa, of the schizophrenic patients, compared to those of controls. These results provide evidence suggesting that adenosine 2a receptors play a role in the pathophysiology of schizophrenia. |
| doi_str_mv | 10.1016/S0006-8993(98)00840-3 |
| format | Article |
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3
H
] CGS21680 as a ligand for the receptor binding assay. There was a significant increase in the specific [
3
H
] CGS21680 binding in the putamen and caudate, but not in the globus pallidus of externa, of the schizophrenic patients, compared to those of controls. These results provide evidence suggesting that adenosine 2a receptors play a role in the pathophysiology of schizophrenia.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(98)00840-3</identifier><identifier>PMID: 9767181</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>[ [formula omitted]] CGS21680 ; Adenosine - analogs & derivatives ; Adenosine - metabolism ; Adenosine - pharmacology ; Adenosine 2a receptors ; Adult ; Adult and adolescent clinical studies ; Aged ; Antihypertensive Agents - metabolism ; Antihypertensive Agents - pharmacology ; Basal ganglia ; Biological and medical sciences ; Brain Chemistry - physiology ; Chronic Disease ; Corpus Striatum - chemistry ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Phenethylamines - metabolism ; Phenethylamines - pharmacology ; Postmortem brain ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Radioligand Assay ; Receptors, Adrenergic, alpha-2 - analysis ; Receptors, Adrenergic, alpha-2 - metabolism ; Schizophrenia ; Schizophrenia - metabolism ; Tritium</subject><ispartof>Brain research, 1998-10, Vol.808 (2), p.320-323</ispartof><rights>1998 Elsevier Science B.V.</rights><rights>1998 INIST-CNRS</rights><rights>Copyright 1998 Elsevier Science B. V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-15644f8d2233fb0b6f4ac372e07c08f88fa51d0986c7aab059b55a50a4eeed523</citedby><cites>FETCH-LOGICAL-c420t-15644f8d2233fb0b6f4ac372e07c08f88fa51d0986c7aab059b55a50a4eeed523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0006-8993(98)00840-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2430882$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9767181$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kurumaji, Akeo</creatorcontrib><creatorcontrib>Toru, Michio</creatorcontrib><title>An increase in [ [formula omitted]] CGS21680 binding in the striatum of postmortem brains of chronic schizophrenics</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>We measured adenosine 2a receptors in basal ganglia of 13 schizophrenics and 10 controls, using [
3
H
] CGS21680 as a ligand for the receptor binding assay. There was a significant increase in the specific [
3
H
] CGS21680 binding in the putamen and caudate, but not in the globus pallidus of externa, of the schizophrenic patients, compared to those of controls. These results provide evidence suggesting that adenosine 2a receptors play a role in the pathophysiology of schizophrenia.</description><subject>[ [formula omitted]] CGS21680</subject><subject>Adenosine - analogs & derivatives</subject><subject>Adenosine - metabolism</subject><subject>Adenosine - pharmacology</subject><subject>Adenosine 2a receptors</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Antihypertensive Agents - metabolism</subject><subject>Antihypertensive Agents - pharmacology</subject><subject>Basal ganglia</subject><subject>Biological and medical sciences</subject><subject>Brain Chemistry - physiology</subject><subject>Chronic Disease</subject><subject>Corpus Striatum - chemistry</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Phenethylamines - metabolism</subject><subject>Phenethylamines - pharmacology</subject><subject>Postmortem brain</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Radioligand Assay</subject><subject>Receptors, Adrenergic, alpha-2 - analysis</subject><subject>Receptors, Adrenergic, alpha-2 - metabolism</subject><subject>Schizophrenia</subject><subject>Schizophrenia - metabolism</subject><subject>Tritium</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EKtvCT6jkA0L0EBh_xLFPqFpBQarEoXCqKstxJqxREi-2gwS_nqS72mtP9sw8M689LyGXDN4zYOrDHQCoShsj3hl9BaAlVOIZ2TDd8EpxCc_J5oS8JOc5_1pCIQyckTPTqIZptiH5eqJh8gldxuVC7-l9H9M4D47GMZSC3cMD3d7ccaY00DZMXZh-rmDZIc0lBVfmkcae7mMuY0wFR9omF6a8Jv0uxSl4mv0u_Iv7XcIlyq_Ii94NGV8fzwvy4_On79sv1e23m6_b69vKSw6lYrWSstcd50L0LbSql86LhiM0HnSvde9q1oHRyjfOtVCbtq5dDU4iYldzcUHeHubuU_w9Yy52DNnjMLgJ45ytMmaREOpJkCnZcG7kAtYH0KeYc8Le7lMYXfprGdjVFfvoil1Xbo22j65YsfRdHgXmdsTu1HW0Yam_OdZd9m7ok5t8yCeMSwFarx_6eMBw2dqfgMlmH3Dy2IWEvtguhice8h8Dh6kX</recordid><startdate>19981019</startdate><enddate>19981019</enddate><creator>Kurumaji, Akeo</creator><creator>Toru, Michio</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19981019</creationdate><title>An increase in [ [formula omitted]] CGS21680 binding in the striatum of postmortem brains of chronic schizophrenics</title><author>Kurumaji, Akeo ; Toru, Michio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-15644f8d2233fb0b6f4ac372e07c08f88fa51d0986c7aab059b55a50a4eeed523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>[ [formula omitted]] CGS21680</topic><topic>Adenosine - analogs & derivatives</topic><topic>Adenosine - metabolism</topic><topic>Adenosine - pharmacology</topic><topic>Adenosine 2a receptors</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Antihypertensive Agents - metabolism</topic><topic>Antihypertensive Agents - pharmacology</topic><topic>Basal ganglia</topic><topic>Biological and medical sciences</topic><topic>Brain Chemistry - physiology</topic><topic>Chronic Disease</topic><topic>Corpus Striatum - chemistry</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Phenethylamines - metabolism</topic><topic>Phenethylamines - pharmacology</topic><topic>Postmortem brain</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Radioligand Assay</topic><topic>Receptors, Adrenergic, alpha-2 - analysis</topic><topic>Receptors, Adrenergic, alpha-2 - metabolism</topic><topic>Schizophrenia</topic><topic>Schizophrenia - metabolism</topic><topic>Tritium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kurumaji, Akeo</creatorcontrib><creatorcontrib>Toru, Michio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kurumaji, Akeo</au><au>Toru, Michio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An increase in [ [formula omitted]] CGS21680 binding in the striatum of postmortem brains of chronic schizophrenics</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1998-10-19</date><risdate>1998</risdate><volume>808</volume><issue>2</issue><spage>320</spage><epage>323</epage><pages>320-323</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>We measured adenosine 2a receptors in basal ganglia of 13 schizophrenics and 10 controls, using [
3
H
] CGS21680 as a ligand for the receptor binding assay. There was a significant increase in the specific [
3
H
] CGS21680 binding in the putamen and caudate, but not in the globus pallidus of externa, of the schizophrenic patients, compared to those of controls. These results provide evidence suggesting that adenosine 2a receptors play a role in the pathophysiology of schizophrenia.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>9767181</pmid><doi>10.1016/S0006-8993(98)00840-3</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-8993 |
| ispartof | Brain research, 1998-10, Vol.808 (2), p.320-323 |
| issn | 0006-8993 1872-6240 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69956436 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | [ [formula omitted]] CGS21680 Adenosine - analogs & derivatives Adenosine - metabolism Adenosine - pharmacology Adenosine 2a receptors Adult Adult and adolescent clinical studies Aged Antihypertensive Agents - metabolism Antihypertensive Agents - pharmacology Basal ganglia Biological and medical sciences Brain Chemistry - physiology Chronic Disease Corpus Striatum - chemistry Female Humans Male Medical sciences Middle Aged Phenethylamines - metabolism Phenethylamines - pharmacology Postmortem brain Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Radioligand Assay Receptors, Adrenergic, alpha-2 - analysis Receptors, Adrenergic, alpha-2 - metabolism Schizophrenia Schizophrenia - metabolism Tritium |
| title | An increase in [ [formula omitted]] CGS21680 binding in the striatum of postmortem brains of chronic schizophrenics |
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