A Novel Class of Orally Active Non-Peptide Bradykinin B2 Receptor Antagonists. 2. Overcoming the Species Difference between Guinea Pig and Man

Recently we reported the identification of a series of 8-[[3-(N-acylglycyl-N-methylamino)-2,6-dichlorobenzyl]oxy]-3-halo-2-methylimidazo[1,2-a]pyridines as the first orally active non-peptide bradykinin (BK) B2 receptor antagonists (1−3). These compounds inhibited the specific binding of [3H]BK to g...

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Veröffentlicht in:	Journal of medicinal chemistry 1998-10, Vol.41 (21), p.4053-4061
Hauptverfasser:	Abe, Yoshito, Kayakiri, Hiroshi, Satoh, Shigeki, Inoue, Takayuki, Sawada, Yuki, Inamura, Noriaki, Asano, Masayuki, Hatori, Chie, Sawai, Hiroe, Oku, Teruo, Tanaka, Hirokazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Bradykinin Receptor Antagonists Bronchoconstriction - drug effects Cell Line Drug Evaluation, Preclinical Guinea Pigs Humans Ileum - drug effects Ileum - metabolism Male Medical sciences Pharmacology. Drug treatments Pyridines - administration & dosage Pyridines - chemical synthesis Pyridines - chemistry Pyridines - pharmacology Receptor, Bradykinin B2 Receptors, Bradykinin - metabolism Respiratory system Species Specificity Structure-Activity Relationship
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