A Targeted DNA-PKcs-Null Mutation Reveals DNA-PK-Independent Functions for KU in V(D)J Recombination

The DNA-dependent protein kinase (DNA-PK) consists of Ku70, Ku80, and a large catalytic subunit, DNA-PKcs. Targeted inactivation of the Ku70 or Ku80 genes results in elevated ionizing radiation (IR) sensitivity and inability to perform both V(D)J coding-end and signal (RS)-end joining in cells, with...

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Veröffentlicht in:Immunity (Cambridge, Mass.) Mass.), 1998-09, Vol.9 (3), p.367-376
Hauptverfasser: Gao, Yijie, Chaudhuri, Jayanta, Zhu, Chengming, Davidson, Laurie, Weaver, David T, Alt, Frederick W
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Sprache:eng
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