Multivariate Analysis for Factors Predicting Rapid Response of Leukocytapheresis in Patients With Steroid-resistant Ulcerative Colitis: A Multicenter Prospective Open-label Study
Leukocytapheresis (LCAP) has been advocated as a treatment for moderate to severe active ulcerative colitis (UC) in Japan. To clarify the predictive factors for a rapid response to LCAP treatment, we conducted a multicenter prospective open‐label study. A total of 105 patients with UC were analyzed....
Gespeichert in:
Veröffentlicht in: | Therapeutic apheresis and dialysis 2008-12, Vol.12 (6), p.484-490 |
---|---|
Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 490 |
---|---|
container_issue | 6 |
container_start_page | 484 |
container_title | Therapeutic apheresis and dialysis |
container_volume | 12 |
creator | Matsumoto, Takayuki Andoh, Akira Okawa, Kiyotaka Ito, Hiroaki Torii, Ayao Yoshikawa, Syusaku Nakaoka, Ryosuke Okuyama, Yusuke Oshitani, Nobuhide Nishishita, Masakazu Watanabe, Kenji Fukunaga, Ken Ohnishi, Kunio Kusaka, Takeshi Yokoyama, Yoko Sasaki, Masaya Tsujikawa, Tomoyuki Aoki, Tetsuya Kusaka, Toshihiro Takeda, Yasuhiro Umehara, Yasushi Nakamura, Shiro Fujiyama, Yoshihide |
description | Leukocytapheresis (LCAP) has been advocated as a treatment for moderate to severe active ulcerative colitis (UC) in Japan. To clarify the predictive factors for a rapid response to LCAP treatment, we conducted a multicenter prospective open‐label study. A total of 105 patients with UC were analyzed. LCAP was performed using a Cellsorba EX column once a week for 5–10 sessions. The response was evaluated by the clinical activity index (CAI). When the CAI score decreased to less than half the pretreatment value or to less than 5 points within 3 weeks, the patient was considered to be a rapid responder. The average CAI significantly decreased from 11.7 to 4.2 (P |
doi_str_mv | 10.1111/j.1744-9987.2008.00639.x |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69954616</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20304692</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4599-1436693fee6b6c522d48c67a2ae9f679b11999920f93cae361baa870b8b8e7b73</originalsourceid><addsrcrecordid>eNqNkc-O0zAQhyMEYpeFV0A-cUuw49SOEZeqogtS6Vb7RytxsRxnwrqbxlnbWdrX4glx2qocYS62NN9vxtaXJIjgjMT6uM4IL4pUiJJnOcZlhjGjItu-SM5PjZenOxdnyRvv1xjneUHp6-SMCFLgsuDnye_vQxvMs3JGBUDTTrU7bzxqrENzpYN1Hq0c1EYH0_1E16o3NboG39vOA7INWsDwaPUuqP4BHIxR06GVCga64NG9CQ_oJoCzpk737aC6gO5aDS4yz4BmtjXB-E9oivYv0TEHLu60vge9R6566NJWVdDGUUO9e5u8alTr4d3xvEju5l9uZ1_TxdXlt9l0kepiIkRKCsqYoA0Aq5ie5HldlJpxlSsQDeOiIkTEynEjqFZAGamUKjmuyqoEXnF6kXw4zO2dfRrAB7kxXkPbqg7s4CUTYlIwwv4J5pjigok8guUB1PF73kEje2c2yu0kwXIUK9dydCZHf3IUK_di5TZG3x93DNUG6r_Bo8kIfD4Av0wLu_8eLG-nq3iJ8fQQj4pge4or9ygZp3wi75eXckFvlvjHci4Z_QNhncUZ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20304692</pqid></control><display><type>article</type><title>Multivariate Analysis for Factors Predicting Rapid Response of Leukocytapheresis in Patients With Steroid-resistant Ulcerative Colitis: A Multicenter Prospective Open-label Study</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Matsumoto, Takayuki ; Andoh, Akira ; Okawa, Kiyotaka ; Ito, Hiroaki ; Torii, Ayao ; Yoshikawa, Syusaku ; Nakaoka, Ryosuke ; Okuyama, Yusuke ; Oshitani, Nobuhide ; Nishishita, Masakazu ; Watanabe, Kenji ; Fukunaga, Ken ; Ohnishi, Kunio ; Kusaka, Takeshi ; Yokoyama, Yoko ; Sasaki, Masaya ; Tsujikawa, Tomoyuki ; Aoki, Tetsuya ; Kusaka, Toshihiro ; Takeda, Yasuhiro ; Umehara, Yasushi ; Nakamura, Shiro ; Fujiyama, Yoshihide</creator><creatorcontrib>Matsumoto, Takayuki ; Andoh, Akira ; Okawa, Kiyotaka ; Ito, Hiroaki ; Torii, Ayao ; Yoshikawa, Syusaku ; Nakaoka, Ryosuke ; Okuyama, Yusuke ; Oshitani, Nobuhide ; Nishishita, Masakazu ; Watanabe, Kenji ; Fukunaga, Ken ; Ohnishi, Kunio ; Kusaka, Takeshi ; Yokoyama, Yoko ; Sasaki, Masaya ; Tsujikawa, Tomoyuki ; Aoki, Tetsuya ; Kusaka, Toshihiro ; Takeda, Yasuhiro ; Umehara, Yasushi ; Nakamura, Shiro ; Fujiyama, Yoshihide</creatorcontrib><description>Leukocytapheresis (LCAP) has been advocated as a treatment for moderate to severe active ulcerative colitis (UC) in Japan. To clarify the predictive factors for a rapid response to LCAP treatment, we conducted a multicenter prospective open‐label study. A total of 105 patients with UC were analyzed. LCAP was performed using a Cellsorba EX column once a week for 5–10 sessions. The response was evaluated by the clinical activity index (CAI). When the CAI score decreased to less than half the pretreatment value or to less than 5 points within 3 weeks, the patient was considered to be a rapid responder. The average CAI significantly decreased from 11.7 to 4.2 (P < 0.01). Seventy‐four percent of the patients responded to the therapy, and 53% of these patients were rapid responders. The following significant factors correlated with the rapid LCAP response: (i) steroid resistance (P < 0.05), (ii) severe disease indicated by a CAI score greater than 11 (P = 0.05), (iii) disease duration of less than 1 year (P < 0.05), and (iv) C‐reactive protein levels before treatment (P < 0.01). These results suggest that the early initiation of LCAP is beneficial in patients with steroid‐resistant UC.</description><identifier>ISSN: 1744-9979</identifier><identifier>EISSN: 1744-9987</identifier><identifier>DOI: 10.1111/j.1744-9987.2008.00639.x</identifier><identifier>PMID: 19140847</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Adolescent ; Adult ; Aged ; Clinical activity index ; Colitis, Ulcerative - therapy ; Drug Resistance ; Female ; Forecasting ; Glucocorticoids - therapeutic use ; Humans ; Japan - epidemiology ; Leukapheresis ; Leukocytapheresis ; Male ; Middle Aged ; Multivariate Analysis ; Predictive factors ; Prospective Studies ; Severity of Illness Index ; Time Factors ; Treatment Outcome ; Ulcerative colitis ; Young Adult</subject><ispartof>Therapeutic apheresis and dialysis, 2008-12, Vol.12 (6), p.484-490</ispartof><rights>2008 The Authors. Journal compilation © 2008 International Society for Apheresis</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4599-1436693fee6b6c522d48c67a2ae9f679b11999920f93cae361baa870b8b8e7b73</citedby><cites>FETCH-LOGICAL-c4599-1436693fee6b6c522d48c67a2ae9f679b11999920f93cae361baa870b8b8e7b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1744-9987.2008.00639.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1744-9987.2008.00639.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19140847$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsumoto, Takayuki</creatorcontrib><creatorcontrib>Andoh, Akira</creatorcontrib><creatorcontrib>Okawa, Kiyotaka</creatorcontrib><creatorcontrib>Ito, Hiroaki</creatorcontrib><creatorcontrib>Torii, Ayao</creatorcontrib><creatorcontrib>Yoshikawa, Syusaku</creatorcontrib><creatorcontrib>Nakaoka, Ryosuke</creatorcontrib><creatorcontrib>Okuyama, Yusuke</creatorcontrib><creatorcontrib>Oshitani, Nobuhide</creatorcontrib><creatorcontrib>Nishishita, Masakazu</creatorcontrib><creatorcontrib>Watanabe, Kenji</creatorcontrib><creatorcontrib>Fukunaga, Ken</creatorcontrib><creatorcontrib>Ohnishi, Kunio</creatorcontrib><creatorcontrib>Kusaka, Takeshi</creatorcontrib><creatorcontrib>Yokoyama, Yoko</creatorcontrib><creatorcontrib>Sasaki, Masaya</creatorcontrib><creatorcontrib>Tsujikawa, Tomoyuki</creatorcontrib><creatorcontrib>Aoki, Tetsuya</creatorcontrib><creatorcontrib>Kusaka, Toshihiro</creatorcontrib><creatorcontrib>Takeda, Yasuhiro</creatorcontrib><creatorcontrib>Umehara, Yasushi</creatorcontrib><creatorcontrib>Nakamura, Shiro</creatorcontrib><creatorcontrib>Fujiyama, Yoshihide</creatorcontrib><title>Multivariate Analysis for Factors Predicting Rapid Response of Leukocytapheresis in Patients With Steroid-resistant Ulcerative Colitis: A Multicenter Prospective Open-label Study</title><title>Therapeutic apheresis and dialysis</title><addtitle>Ther Apher Dial</addtitle><description>Leukocytapheresis (LCAP) has been advocated as a treatment for moderate to severe active ulcerative colitis (UC) in Japan. To clarify the predictive factors for a rapid response to LCAP treatment, we conducted a multicenter prospective open‐label study. A total of 105 patients with UC were analyzed. LCAP was performed using a Cellsorba EX column once a week for 5–10 sessions. The response was evaluated by the clinical activity index (CAI). When the CAI score decreased to less than half the pretreatment value or to less than 5 points within 3 weeks, the patient was considered to be a rapid responder. The average CAI significantly decreased from 11.7 to 4.2 (P < 0.01). Seventy‐four percent of the patients responded to the therapy, and 53% of these patients were rapid responders. The following significant factors correlated with the rapid LCAP response: (i) steroid resistance (P < 0.05), (ii) severe disease indicated by a CAI score greater than 11 (P = 0.05), (iii) disease duration of less than 1 year (P < 0.05), and (iv) C‐reactive protein levels before treatment (P < 0.01). These results suggest that the early initiation of LCAP is beneficial in patients with steroid‐resistant UC.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Clinical activity index</subject><subject>Colitis, Ulcerative - therapy</subject><subject>Drug Resistance</subject><subject>Female</subject><subject>Forecasting</subject><subject>Glucocorticoids - therapeutic use</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Leukapheresis</subject><subject>Leukocytapheresis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Predictive factors</subject><subject>Prospective Studies</subject><subject>Severity of Illness Index</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Ulcerative colitis</subject><subject>Young Adult</subject><issn>1744-9979</issn><issn>1744-9987</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc-O0zAQhyMEYpeFV0A-cUuw49SOEZeqogtS6Vb7RytxsRxnwrqbxlnbWdrX4glx2qocYS62NN9vxtaXJIjgjMT6uM4IL4pUiJJnOcZlhjGjItu-SM5PjZenOxdnyRvv1xjneUHp6-SMCFLgsuDnye_vQxvMs3JGBUDTTrU7bzxqrENzpYN1Hq0c1EYH0_1E16o3NboG39vOA7INWsDwaPUuqP4BHIxR06GVCga64NG9CQ_oJoCzpk737aC6gO5aDS4yz4BmtjXB-E9oivYv0TEHLu60vge9R6566NJWVdDGUUO9e5u8alTr4d3xvEju5l9uZ1_TxdXlt9l0kepiIkRKCsqYoA0Aq5ie5HldlJpxlSsQDeOiIkTEynEjqFZAGamUKjmuyqoEXnF6kXw4zO2dfRrAB7kxXkPbqg7s4CUTYlIwwv4J5pjigok8guUB1PF73kEje2c2yu0kwXIUK9dydCZHf3IUK_di5TZG3x93DNUG6r_Bo8kIfD4Av0wLu_8eLG-nq3iJ8fQQj4pge4or9ygZp3wi75eXckFvlvjHci4Z_QNhncUZ</recordid><startdate>200812</startdate><enddate>200812</enddate><creator>Matsumoto, Takayuki</creator><creator>Andoh, Akira</creator><creator>Okawa, Kiyotaka</creator><creator>Ito, Hiroaki</creator><creator>Torii, Ayao</creator><creator>Yoshikawa, Syusaku</creator><creator>Nakaoka, Ryosuke</creator><creator>Okuyama, Yusuke</creator><creator>Oshitani, Nobuhide</creator><creator>Nishishita, Masakazu</creator><creator>Watanabe, Kenji</creator><creator>Fukunaga, Ken</creator><creator>Ohnishi, Kunio</creator><creator>Kusaka, Takeshi</creator><creator>Yokoyama, Yoko</creator><creator>Sasaki, Masaya</creator><creator>Tsujikawa, Tomoyuki</creator><creator>Aoki, Tetsuya</creator><creator>Kusaka, Toshihiro</creator><creator>Takeda, Yasuhiro</creator><creator>Umehara, Yasushi</creator><creator>Nakamura, Shiro</creator><creator>Fujiyama, Yoshihide</creator><general>Blackwell Publishing Asia</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200812</creationdate><title>Multivariate Analysis for Factors Predicting Rapid Response of Leukocytapheresis in Patients With Steroid-resistant Ulcerative Colitis: A Multicenter Prospective Open-label Study</title><author>Matsumoto, Takayuki ; Andoh, Akira ; Okawa, Kiyotaka ; Ito, Hiroaki ; Torii, Ayao ; Yoshikawa, Syusaku ; Nakaoka, Ryosuke ; Okuyama, Yusuke ; Oshitani, Nobuhide ; Nishishita, Masakazu ; Watanabe, Kenji ; Fukunaga, Ken ; Ohnishi, Kunio ; Kusaka, Takeshi ; Yokoyama, Yoko ; Sasaki, Masaya ; Tsujikawa, Tomoyuki ; Aoki, Tetsuya ; Kusaka, Toshihiro ; Takeda, Yasuhiro ; Umehara, Yasushi ; Nakamura, Shiro ; Fujiyama, Yoshihide</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4599-1436693fee6b6c522d48c67a2ae9f679b11999920f93cae361baa870b8b8e7b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Clinical activity index</topic><topic>Colitis, Ulcerative - therapy</topic><topic>Drug Resistance</topic><topic>Female</topic><topic>Forecasting</topic><topic>Glucocorticoids - therapeutic use</topic><topic>Humans</topic><topic>Japan - epidemiology</topic><topic>Leukapheresis</topic><topic>Leukocytapheresis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Predictive factors</topic><topic>Prospective Studies</topic><topic>Severity of Illness Index</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Ulcerative colitis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsumoto, Takayuki</creatorcontrib><creatorcontrib>Andoh, Akira</creatorcontrib><creatorcontrib>Okawa, Kiyotaka</creatorcontrib><creatorcontrib>Ito, Hiroaki</creatorcontrib><creatorcontrib>Torii, Ayao</creatorcontrib><creatorcontrib>Yoshikawa, Syusaku</creatorcontrib><creatorcontrib>Nakaoka, Ryosuke</creatorcontrib><creatorcontrib>Okuyama, Yusuke</creatorcontrib><creatorcontrib>Oshitani, Nobuhide</creatorcontrib><creatorcontrib>Nishishita, Masakazu</creatorcontrib><creatorcontrib>Watanabe, Kenji</creatorcontrib><creatorcontrib>Fukunaga, Ken</creatorcontrib><creatorcontrib>Ohnishi, Kunio</creatorcontrib><creatorcontrib>Kusaka, Takeshi</creatorcontrib><creatorcontrib>Yokoyama, Yoko</creatorcontrib><creatorcontrib>Sasaki, Masaya</creatorcontrib><creatorcontrib>Tsujikawa, Tomoyuki</creatorcontrib><creatorcontrib>Aoki, Tetsuya</creatorcontrib><creatorcontrib>Kusaka, Toshihiro</creatorcontrib><creatorcontrib>Takeda, Yasuhiro</creatorcontrib><creatorcontrib>Umehara, Yasushi</creatorcontrib><creatorcontrib>Nakamura, Shiro</creatorcontrib><creatorcontrib>Fujiyama, Yoshihide</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Therapeutic apheresis and dialysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsumoto, Takayuki</au><au>Andoh, Akira</au><au>Okawa, Kiyotaka</au><au>Ito, Hiroaki</au><au>Torii, Ayao</au><au>Yoshikawa, Syusaku</au><au>Nakaoka, Ryosuke</au><au>Okuyama, Yusuke</au><au>Oshitani, Nobuhide</au><au>Nishishita, Masakazu</au><au>Watanabe, Kenji</au><au>Fukunaga, Ken</au><au>Ohnishi, Kunio</au><au>Kusaka, Takeshi</au><au>Yokoyama, Yoko</au><au>Sasaki, Masaya</au><au>Tsujikawa, Tomoyuki</au><au>Aoki, Tetsuya</au><au>Kusaka, Toshihiro</au><au>Takeda, Yasuhiro</au><au>Umehara, Yasushi</au><au>Nakamura, Shiro</au><au>Fujiyama, Yoshihide</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multivariate Analysis for Factors Predicting Rapid Response of Leukocytapheresis in Patients With Steroid-resistant Ulcerative Colitis: A Multicenter Prospective Open-label Study</atitle><jtitle>Therapeutic apheresis and dialysis</jtitle><addtitle>Ther Apher Dial</addtitle><date>2008-12</date><risdate>2008</risdate><volume>12</volume><issue>6</issue><spage>484</spage><epage>490</epage><pages>484-490</pages><issn>1744-9979</issn><eissn>1744-9987</eissn><abstract>Leukocytapheresis (LCAP) has been advocated as a treatment for moderate to severe active ulcerative colitis (UC) in Japan. To clarify the predictive factors for a rapid response to LCAP treatment, we conducted a multicenter prospective open‐label study. A total of 105 patients with UC were analyzed. LCAP was performed using a Cellsorba EX column once a week for 5–10 sessions. The response was evaluated by the clinical activity index (CAI). When the CAI score decreased to less than half the pretreatment value or to less than 5 points within 3 weeks, the patient was considered to be a rapid responder. The average CAI significantly decreased from 11.7 to 4.2 (P < 0.01). Seventy‐four percent of the patients responded to the therapy, and 53% of these patients were rapid responders. The following significant factors correlated with the rapid LCAP response: (i) steroid resistance (P < 0.05), (ii) severe disease indicated by a CAI score greater than 11 (P = 0.05), (iii) disease duration of less than 1 year (P < 0.05), and (iv) C‐reactive protein levels before treatment (P < 0.01). These results suggest that the early initiation of LCAP is beneficial in patients with steroid‐resistant UC.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>19140847</pmid><doi>10.1111/j.1744-9987.2008.00639.x</doi><tpages>7</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1744-9979 |
ispartof | Therapeutic apheresis and dialysis, 2008-12, Vol.12 (6), p.484-490 |
issn | 1744-9979 1744-9987 |
language | eng |
recordid | cdi_proquest_miscellaneous_69954616 |
source | MEDLINE; Access via Wiley Online Library |
subjects | Adolescent Adult Aged Clinical activity index Colitis, Ulcerative - therapy Drug Resistance Female Forecasting Glucocorticoids - therapeutic use Humans Japan - epidemiology Leukapheresis Leukocytapheresis Male Middle Aged Multivariate Analysis Predictive factors Prospective Studies Severity of Illness Index Time Factors Treatment Outcome Ulcerative colitis Young Adult |
title | Multivariate Analysis for Factors Predicting Rapid Response of Leukocytapheresis in Patients With Steroid-resistant Ulcerative Colitis: A Multicenter Prospective Open-label Study |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T09%3A42%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Multivariate%20Analysis%20for%20Factors%20Predicting%20Rapid%20Response%20of%20Leukocytapheresis%20in%20Patients%20With%20Steroid-resistant%20Ulcerative%20Colitis:%20A%20Multicenter%20Prospective%20Open-label%20Study&rft.jtitle=Therapeutic%20apheresis%20and%20dialysis&rft.au=Matsumoto,%20Takayuki&rft.date=2008-12&rft.volume=12&rft.issue=6&rft.spage=484&rft.epage=490&rft.pages=484-490&rft.issn=1744-9979&rft.eissn=1744-9987&rft_id=info:doi/10.1111/j.1744-9987.2008.00639.x&rft_dat=%3Cproquest_cross%3E20304692%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20304692&rft_id=info:pmid/19140847&rfr_iscdi=true |