Multivariate Analysis for Factors Predicting Rapid Response of Leukocytapheresis in Patients With Steroid-resistant Ulcerative Colitis: A Multicenter Prospective Open-label Study

Multivariate Analysis for Factors Predicting Rapid Response of Leukocytapheresis in Patients With Steroid-resistant Ulcerative Colitis: A Multicenter Prospective Open-label Study

Leukocytapheresis (LCAP) has been advocated as a treatment for moderate to severe active ulcerative colitis (UC) in Japan. To clarify the predictive factors for a rapid response to LCAP treatment, we conducted a multicenter prospective open‐label study. A total of 105 patients with UC were analyzed....

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Veröffentlicht in:Therapeutic apheresis and dialysis 2008-12, Vol.12 (6), p.484-490
Hauptverfasser: Matsumoto, Takayuki, Andoh, Akira, Okawa, Kiyotaka, Ito, Hiroaki, Torii, Ayao, Yoshikawa, Syusaku, Nakaoka, Ryosuke, Okuyama, Yusuke, Oshitani, Nobuhide, Nishishita, Masakazu, Watanabe, Kenji, Fukunaga, Ken, Ohnishi, Kunio, Kusaka, Takeshi, Yokoyama, Yoko, Sasaki, Masaya, Tsujikawa, Tomoyuki, Aoki, Tetsuya, Kusaka, Toshihiro, Takeda, Yasuhiro, Umehara, Yasushi, Nakamura, Shiro, Fujiyama, Yoshihide
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Aged
Clinical activity index
Colitis, Ulcerative - therapy
Drug Resistance
Female
Forecasting
Glucocorticoids - therapeutic use
Humans
Japan - epidemiology
Leukapheresis
Leukocytapheresis
Male
Middle Aged
Multivariate Analysis
Predictive factors
Prospective Studies
Severity of Illness Index
Time Factors
Treatment Outcome
Ulcerative colitis
Young Adult
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Zusammenfassung:Leukocytapheresis (LCAP) has been advocated as a treatment for moderate to severe active ulcerative colitis (UC) in Japan. To clarify the predictive factors for a rapid response to LCAP treatment, we conducted a multicenter prospective open‐label study. A total of 105 patients with UC were analyzed. LCAP was performed using a Cellsorba EX column once a week for 5–10 sessions. The response was evaluated by the clinical activity index (CAI). When the CAI score decreased to less than half the pretreatment value or to less than 5 points within 3 weeks, the patient was considered to be a rapid responder. The average CAI significantly decreased from 11.7 to 4.2 (P 
ISSN:1744-9979
1744-9987
DOI:10.1111/j.1744-9987.2008.00639.x