Epstein-Barr Virus LMP2A Drives B Cell Development and Survival in the Absence of Normal B Cell Receptor Signals

Epstein-Barr virus (EBV) establishes a persistent latent infection in peripheral B lymphocytes in humans and is associated with a variety of malignancies and proliferative disorders. Latent membrane protein 2A (LMP2A) is one of only two viral proteins expressed in latently infected B lymphocytes in...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 1998-09, Vol.9 (3), p.405-411
Hauptverfasser:	Caldwell, Robert G, Wilson, Joanna B, Anderson, Steven J, Longnecker, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified B-Lymphocytes - cytology B-Lymphocytes - virology Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Bone Marrow Cells - immunology Cell Differentiation Cell Survival Cells, Cultured Gene Rearrangement, B-Lymphocyte, Heavy Chain - drug effects Gene Rearrangement, B-Lymphocyte, Heavy Chain - physiology Genes, RAG-1 - physiology Herpesvirus 4, Human - chemistry Herpesvirus 4, Human - immunology Interleukin-7 - pharmacology Lymphocyte Activation - drug effects Mice Mice, Inbred C57BL Mice, Transgenic Receptors, Antigen, B-Cell - physiology Signal Transduction Transgenes - physiology Viral Matrix Proteins - genetics Viral Matrix Proteins - physiology
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