Epstein-Barr Virus LMP2A Drives B Cell Development and Survival in the Absence of Normal B Cell Receptor Signals
Epstein-Barr virus (EBV) establishes a persistent latent infection in peripheral B lymphocytes in humans and is associated with a variety of malignancies and proliferative disorders. Latent membrane protein 2A (LMP2A) is one of only two viral proteins expressed in latently infected B lymphocytes in...
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| Veröffentlicht in: | Immunity (Cambridge, Mass.) Mass.), 1998-09, Vol.9 (3), p.405-411 |
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| creator | Caldwell, Robert G Wilson, Joanna B Anderson, Steven J Longnecker, Richard |
| description | Epstein-Barr virus (EBV) establishes a persistent latent infection in peripheral B lymphocytes in humans and is associated with a variety of malignancies and proliferative disorders. Latent membrane protein 2A (LMP2A) is one of only two viral proteins expressed in latently infected B lymphocytes in vivo. LMP2A blocks B cell receptor (BCR) signal transduction in vitro by binding the Syk and Lyn protein tyrosine kinases. To analyze the significance of LMP2A expression in vivo, transgenic mice with B cell lineage expression of LMP2A were generated. LMP2A expression results in the bypass of normal B lymphocyte developmental checkpoints allowing immunoglobulin-negative cells to colonize peripheral lymphoid organs, indicating that LMP2A possesses a constitutive signaling activity in nontransformed cells. |
| doi_str_mv | 10.1016/S1074-7613(00)80623-8 |
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Latent membrane protein 2A (LMP2A) is one of only two viral proteins expressed in latently infected B lymphocytes in vivo. LMP2A blocks B cell receptor (BCR) signal transduction in vitro by binding the Syk and Lyn protein tyrosine kinases. To analyze the significance of LMP2A expression in vivo, transgenic mice with B cell lineage expression of LMP2A were generated. 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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Animals, Genetically Modified B-Lymphocytes - cytology B-Lymphocytes - virology Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Bone Marrow Cells - immunology Cell Differentiation Cell Survival Cells, Cultured Gene Rearrangement, B-Lymphocyte, Heavy Chain - drug effects Gene Rearrangement, B-Lymphocyte, Heavy Chain - physiology Genes, RAG-1 - physiology Herpesvirus 4, Human - chemistry Herpesvirus 4, Human - immunology Interleukin-7 - pharmacology Lymphocyte Activation - drug effects Mice Mice, Inbred C57BL Mice, Transgenic Receptors, Antigen, B-Cell - physiology Signal Transduction Transgenes - physiology Viral Matrix Proteins - genetics Viral Matrix Proteins - physiology |
| title | Epstein-Barr Virus LMP2A Drives B Cell Development and Survival in the Absence of Normal B Cell Receptor Signals |
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