A new contained human immunodeficiency virus type 1 host cell system for evaluation of antiviral activities of interferons and other agents in vitro

HIV-host infection systems in vitro are important in the pre-clinical assessment of anti-retroviral drug activity. The present report describes the development of a new HIV-host model comprised of an epithelial cell line of HeLa lineage (HeLa-1), transfected with expression vectors bearing tat and r...

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Veröffentlicht in:	Antiviral research 1999-07, Vol.42 (3), p.177-187
Hauptverfasser:	Moussazadeh, Mitra, Hua, Ji, Sidhu, Maninder K., Zhao, Xiao-Xia, Fitzgibbon, Joseph E., Liao, Mei-June, Rashidbaigi, Abbas
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Anti-HIV Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral Antiviral agents Biological and medical sciences CD4 Antigens - genetics Drug Evaluation, Preclinical - methods Epithelial cells Gene Expression Gene Products, rev - genetics Gene Products, tat - genetics HeLa Cells HIV HIV Protease Inhibitors - pharmacology HIV-1 - drug effects Human immunodeficiency virus 1 Humans IFN In Vitro Techniques Interferon-alpha - pharmacology Medical sciences Nelfinavir - pharmacology Pharmacology. Drug treatments rev Gene Products, Human Immunodeficiency Virus Reverse Transcriptase Inhibitors - pharmacology Ritonavir - pharmacology Saquinavir - pharmacology tat Gene Products, Human Immunodeficiency Virus Zidovudine - pharmacology
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