Anthrax Protective Antigen: Prepore-to-Pore Conversion

PA63, the active 63 kDa form of anthrax protective antigen, forms a heptameric ring-shaped oligomer that is believed to represent a precursor of the membrane pore formed by this protein. When maintained at pH ≥8.0, this “prepore” dissociated to monomeric subunits upon treatment with SDS at room temp...

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Veröffentlicht in:	Biochemistry (Easton) 1999-08, Vol.38 (32), p.10432-10441
Hauptverfasser:	Miller, Carl J, Elliott, Jennifer L, Collier, R. John
Format:	Artikel
Sprache:	eng
Schlagworte:	anthrax anthrax toxin antigens Antigens, Bacterial - chemistry Antigens, Bacterial - genetics Antigens, Bacterial - metabolism Antigens, Bacterial - physiology Bacillus anthracis Bacillus anthracis - chemistry Bacillus anthracis - genetics Bacillus anthracis - metabolism Bacillus anthracis - pathogenicity bacterial toxins Bacterial Toxins - chemistry Bacterial Toxins - genetics Bacterial Toxins - metabolism Biological Transport - drug effects Biological Transport - genetics Cholic Acids - pharmacology Chymotrypsin - metabolism Detergents - pharmacology Hydrogen-Ion Concentration Hydrolysis Ion Channels - chemistry Ion Channels - genetics Ion Channels - metabolism Ion Channels - physiology Models, Biological Models, Molecular PA63 protein protective antigen Protein Structure, Secondary - drug effects Sequence Deletion Spectrometry, Fluorescence
Online-Zugang:	Volltext
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