A Novel Class of Adenosine A3 Receptor Ligands. 1. 3-(2-Pyridinyl)isoquinoline Derivatives

A series of 3-(2-pyridinyl)isoquinoline derivatives was synthesized as potential antagonists for the human adenosine A3 receptor by substitution of the 1-position. The compounds were obtained by various synthetic routes from 1-amino-3-(2-pyridinyl)isoquinoline. The affinity was determined in radioli...

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Veröffentlicht in:	Journal of medicinal chemistry 1998-10, Vol.41 (21), p.3987-3993
Hauptverfasser:	van Muijlwijk-Koezen, Jacqueline E, Timmerman, Henk, Link, Regina, van der Goot, Henk, IJzerman, Adriaan P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzamidines - chemical synthesis Benzamidines - chemistry Benzamidines - metabolism Benzamidines - pharmacology Biological and medical sciences Cell Line Cerebral Cortex - metabolism CHO Cells Corpus Striatum - metabolism Cricetinae Humans In Vitro Techniques Isoquinolines - chemical synthesis Isoquinolines - chemistry Isoquinolines - metabolism Isoquinolines - pharmacology Ligands Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Purinergic P1 Receptor Antagonists Rats Receptor, Adenosine A2A Receptor, Adenosine A3 Receptors, Purinergic P1 - biosynthesis Receptors, Purinergic P1 - metabolism Structure-Activity Relationship
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