Amplifications of DNA primase 1 (PRIM1) in human osteosarcoma

We studied the involvement of PRIM1 in osteosarcoma by differential display, Northern and Southern hybridization, as well as fluorescence in situ hybridization (FISH) on interphase nuclei. In total, 22 pediatric oncology specimens were tested. PRIM1 was found to be amplified in 41% of the samples. P...

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Veröffentlicht in:	Genes chromosomes & cancer 1999-09, Vol.26 (1), p.62-69
Hauptverfasser:	Yotov, Wagner V., Hamel, Hugo, Rivard, George-Etienne, Champagne, Martin A., Russo, Pierre A., Leclerc, Jean-Marie, Bernstein, Mark L., Levy, Emile
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Northern Bone Neoplasms - enzymology Bone Neoplasms - genetics Chromosomes, Human, Pair 12 - genetics Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinases - genetics DNA Primase - genetics DNA, Neoplasm - genetics Gene Amplification Gene Expression Regulation, Neoplastic HeLa Cells Humans Hybrid Cells In Situ Hybridization, Fluorescence Lectins Membrane Proteins - genetics Neoplasm Proteins - genetics Osteosarcoma - enzymology Osteosarcoma - genetics Physical Chromosome Mapping Proto-Oncogene Proteins RNA, Messenger - genetics Tetraspanins Tumor Cells, Cultured
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