Dopamine D2 Receptor Density and Personal Detachment in Healthy Subjects
Objective:The purpose of this study was to examine the relationship between the personality trait involving personal detachment and dopamine D2 receptor specific binding in healthy subjects.Method:Eighteen adult subjects completed the Karolinska Scales of Personality and the Tridimensional Personali...
Gespeichert in:
| Veröffentlicht in: | The American journal of psychiatry 1998-10, Vol.155 (10), p.1440-1442 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1442 |
|---|---|
| container_issue | 10 |
| container_start_page | 1440 |
| container_title | The American journal of psychiatry |
| container_volume | 155 |
| creator | Breier, Alan Kestler, Lisa Adler, Caleb Elman, Igor Wiesenfeld, Neil Malhotra, Anil Pickar, David |
| description | Objective:The purpose of this study was to examine the relationship between the personality trait involving personal detachment and dopamine D2 receptor specific binding in healthy subjects.Method:Eighteen adult subjects completed the Karolinska Scales of Personality and the Tridimensional Personality Questionnaire and participated in a study that used [11C]raclopride positron emission tomography (PET) to quantify striatal D2 receptor binding. Results:A significant relationship was found between D2 receptor specific binding and detachment scores on the Karolinska Scales of Personality but not between D2 receptor specific binding and attachment scores on the Tridimensional Personality Questionnaire. In an exploratory analysis, the authors found a significant relationship between binding and the sentimentality cluster on the Tridimensional Personality Questionnaire but on no other personality clusters scores on the Tridimensional Personality Questionnaire or Karolinska Scales of Personality.Conclusions:These findings replicate those of a recent report that personal detachment scores on the Karolinska Scales of Personality are related to dopamine D2 receptor density and extends this finding by suggesting that the relationship is relatively specific to the trait defined by the Karolinska Scales of Personality and does not generalize to other forms of detachment. Am J Psychiatry 1998; 155: 1440-1442 |
| doi_str_mv | 10.1176/ajp.155.10.1440 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_69945958</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>57375285</sourcerecordid><originalsourceid>FETCH-LOGICAL-a339t-77f86bbeeb0dceb1bdd2c3ad22957a075417d00dc3ef676c6695b22285fef5e13</originalsourceid><addsrcrecordid>eNqFkUlLxEAQhRtRdFzOnoSg4smMvaS70keZUUcYUFzAW-h0Kpghm-nkMP_eVoOIIJ6KV--jiqpHyCGjU8ZAXZhVO2VSTj90FNENMmFSyBA4jzfJhFLKQy3Fyw7ZdW7lJRXAt8m2BqUA9IQs5k1rqqLGYM6DB7TY9k0XzLF2Rb8OTJ0F99i5pjalb_bGvlZY90FRBws0Zf-6Dh6HdIW2d_tkKzelw4Ox7pHn66un2SJc3t3czi6XoRFC9yFAHqs0RUxpZjFlaZZxK0zGuZZgKMiIQUa9JzBXoKxSWqbcXyNzzCUysUfOvua2XfM2oOuTqnAWy9LU2AwuUVpHUsv4X1CCAOnnevD4F7hqhs5f7BLOaQSKC-2hk78gJlks_ENBeepopIa0wixpu6Iy3ToZ3-3909E3zpoy70xtC_eN8YjHPAKPnX9hpm2LH4to8pF54jP3S-Wn9pmLdwpiml8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1518397676</pqid></control><display><type>article</type><title>Dopamine D2 Receptor Density and Personal Detachment in Healthy Subjects</title><source>MEDLINE</source><source>American Psychiatric Publishing Journals (1997-Present)</source><source>Periodicals Index Online</source><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Breier, Alan ; Kestler, Lisa ; Adler, Caleb ; Elman, Igor ; Wiesenfeld, Neil ; Malhotra, Anil ; Pickar, David</creator><creatorcontrib>Breier, Alan ; Kestler, Lisa ; Adler, Caleb ; Elman, Igor ; Wiesenfeld, Neil ; Malhotra, Anil ; Pickar, David</creatorcontrib><description>Objective:The purpose of this study was to examine the relationship between the personality trait involving personal detachment and dopamine D2 receptor specific binding in healthy subjects.Method:Eighteen adult subjects completed the Karolinska Scales of Personality and the Tridimensional Personality Questionnaire and participated in a study that used [11C]raclopride positron emission tomography (PET) to quantify striatal D2 receptor binding. Results:A significant relationship was found between D2 receptor specific binding and detachment scores on the Karolinska Scales of Personality but not between D2 receptor specific binding and attachment scores on the Tridimensional Personality Questionnaire. In an exploratory analysis, the authors found a significant relationship between binding and the sentimentality cluster on the Tridimensional Personality Questionnaire but on no other personality clusters scores on the Tridimensional Personality Questionnaire or Karolinska Scales of Personality.Conclusions:These findings replicate those of a recent report that personal detachment scores on the Karolinska Scales of Personality are related to dopamine D2 receptor density and extends this finding by suggesting that the relationship is relatively specific to the trait defined by the Karolinska Scales of Personality and does not generalize to other forms of detachment. Am J Psychiatry 1998; 155: 1440-1442</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/ajp.155.10.1440</identifier><identifier>PMID: 9766779</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>Washington, DC: American Psychiatric Publishing</publisher><subject>Adult ; Biological and medical sciences ; Carbon Radioisotopes ; Corpus Striatum - diagnostic imaging ; Corpus Striatum - metabolism ; Dopamine ; Dopamine Antagonists ; Female ; Fundamental and applied biological sciences. Psychology ; Health Status ; Humans ; Male ; Molecular biology ; Personality ; Personality - physiology ; Personality Assessment - statistics & numerical data ; Personality traits ; Personality. Affectivity ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Raclopride ; Receptor status ; Receptors, Dopamine D2 - metabolism ; Receptors, Dopamine D2 - physiology ; Relationship ; Salicylamides ; Social attachment ; Tomography, Emission-Computed</subject><ispartof>The American journal of psychiatry, 1998-10, Vol.155 (10), p.1440-1442</ispartof><rights>1998 INIST-CNRS</rights><rights>Copyright American Psychiatric Association Oct 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/ajp.155.10.1440$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/ajp.155.10.1440$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,780,784,21624,21625,21626,27867,27922,27923,30998,77564,77569</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2428247$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9766779$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Breier, Alan</creatorcontrib><creatorcontrib>Kestler, Lisa</creatorcontrib><creatorcontrib>Adler, Caleb</creatorcontrib><creatorcontrib>Elman, Igor</creatorcontrib><creatorcontrib>Wiesenfeld, Neil</creatorcontrib><creatorcontrib>Malhotra, Anil</creatorcontrib><creatorcontrib>Pickar, David</creatorcontrib><title>Dopamine D2 Receptor Density and Personal Detachment in Healthy Subjects</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>Objective:The purpose of this study was to examine the relationship between the personality trait involving personal detachment and dopamine D2 receptor specific binding in healthy subjects.Method:Eighteen adult subjects completed the Karolinska Scales of Personality and the Tridimensional Personality Questionnaire and participated in a study that used [11C]raclopride positron emission tomography (PET) to quantify striatal D2 receptor binding. Results:A significant relationship was found between D2 receptor specific binding and detachment scores on the Karolinska Scales of Personality but not between D2 receptor specific binding and attachment scores on the Tridimensional Personality Questionnaire. In an exploratory analysis, the authors found a significant relationship between binding and the sentimentality cluster on the Tridimensional Personality Questionnaire but on no other personality clusters scores on the Tridimensional Personality Questionnaire or Karolinska Scales of Personality.Conclusions:These findings replicate those of a recent report that personal detachment scores on the Karolinska Scales of Personality are related to dopamine D2 receptor density and extends this finding by suggesting that the relationship is relatively specific to the trait defined by the Karolinska Scales of Personality and does not generalize to other forms of detachment. Am J Psychiatry 1998; 155: 1440-1442</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Carbon Radioisotopes</subject><subject>Corpus Striatum - diagnostic imaging</subject><subject>Corpus Striatum - metabolism</subject><subject>Dopamine</subject><subject>Dopamine Antagonists</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Health Status</subject><subject>Humans</subject><subject>Male</subject><subject>Molecular biology</subject><subject>Personality</subject><subject>Personality - physiology</subject><subject>Personality Assessment - statistics & numerical data</subject><subject>Personality traits</subject><subject>Personality. Affectivity</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Raclopride</subject><subject>Receptor status</subject><subject>Receptors, Dopamine D2 - metabolism</subject><subject>Receptors, Dopamine D2 - physiology</subject><subject>Relationship</subject><subject>Salicylamides</subject><subject>Social attachment</subject><subject>Tomography, Emission-Computed</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>K30</sourceid><sourceid>7QJ</sourceid><recordid>eNqFkUlLxEAQhRtRdFzOnoSg4smMvaS70keZUUcYUFzAW-h0Kpghm-nkMP_eVoOIIJ6KV--jiqpHyCGjU8ZAXZhVO2VSTj90FNENMmFSyBA4jzfJhFLKQy3Fyw7ZdW7lJRXAt8m2BqUA9IQs5k1rqqLGYM6DB7TY9k0XzLF2Rb8OTJ0F99i5pjalb_bGvlZY90FRBws0Zf-6Dh6HdIW2d_tkKzelw4Ox7pHn66un2SJc3t3czi6XoRFC9yFAHqs0RUxpZjFlaZZxK0zGuZZgKMiIQUa9JzBXoKxSWqbcXyNzzCUysUfOvua2XfM2oOuTqnAWy9LU2AwuUVpHUsv4X1CCAOnnevD4F7hqhs5f7BLOaQSKC-2hk78gJlks_ENBeepopIa0wixpu6Iy3ToZ3-3909E3zpoy70xtC_eN8YjHPAKPnX9hpm2LH4to8pF54jP3S-Wn9pmLdwpiml8</recordid><startdate>199810</startdate><enddate>199810</enddate><creator>Breier, Alan</creator><creator>Kestler, Lisa</creator><creator>Adler, Caleb</creator><creator>Elman, Igor</creator><creator>Wiesenfeld, Neil</creator><creator>Malhotra, Anil</creator><creator>Pickar, David</creator><general>American Psychiatric Publishing</general><general>American Psychiatric Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>HAWNG</scope><scope>HBMBR</scope><scope>IBDFT</scope><scope>K30</scope><scope>PAAUG</scope><scope>PAWHS</scope><scope>PAWZZ</scope><scope>PAXOH</scope><scope>PBHAV</scope><scope>PBQSW</scope><scope>PBYQZ</scope><scope>PCIWU</scope><scope>PCMID</scope><scope>PCZJX</scope><scope>PDGRG</scope><scope>PDWWI</scope><scope>PETMR</scope><scope>PFVGT</scope><scope>PGXDX</scope><scope>PIHIL</scope><scope>PISVA</scope><scope>PJCTQ</scope><scope>PJTMS</scope><scope>PLCHJ</scope><scope>PMHAD</scope><scope>PNQDJ</scope><scope>POUND</scope><scope>PPLAD</scope><scope>PQAPC</scope><scope>PQCAN</scope><scope>PQCMW</scope><scope>PQEME</scope><scope>PQHKH</scope><scope>PQMID</scope><scope>PQNCT</scope><scope>PQNET</scope><scope>PQSCT</scope><scope>PQSET</scope><scope>PSVJG</scope><scope>PVMQY</scope><scope>PZGFC</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7QJ</scope><scope>7X8</scope></search><sort><creationdate>199810</creationdate><title>Dopamine D2 Receptor Density and Personal Detachment in Healthy Subjects</title><author>Breier, Alan ; Kestler, Lisa ; Adler, Caleb ; Elman, Igor ; Wiesenfeld, Neil ; Malhotra, Anil ; Pickar, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a339t-77f86bbeeb0dceb1bdd2c3ad22957a075417d00dc3ef676c6695b22285fef5e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Carbon Radioisotopes</topic><topic>Corpus Striatum - diagnostic imaging</topic><topic>Corpus Striatum - metabolism</topic><topic>Dopamine</topic><topic>Dopamine Antagonists</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Health Status</topic><topic>Humans</topic><topic>Male</topic><topic>Molecular biology</topic><topic>Personality</topic><topic>Personality - physiology</topic><topic>Personality Assessment - statistics & numerical data</topic><topic>Personality traits</topic><topic>Personality. Affectivity</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Raclopride</topic><topic>Receptor status</topic><topic>Receptors, Dopamine D2 - metabolism</topic><topic>Receptors, Dopamine D2 - physiology</topic><topic>Relationship</topic><topic>Salicylamides</topic><topic>Social attachment</topic><topic>Tomography, Emission-Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Breier, Alan</creatorcontrib><creatorcontrib>Kestler, Lisa</creatorcontrib><creatorcontrib>Adler, Caleb</creatorcontrib><creatorcontrib>Elman, Igor</creatorcontrib><creatorcontrib>Wiesenfeld, Neil</creatorcontrib><creatorcontrib>Malhotra, Anil</creatorcontrib><creatorcontrib>Pickar, David</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Periodicals Index Online Segment 13</collection><collection>Periodicals Index Online Segment 14</collection><collection>Periodicals Index Online Segment 27</collection><collection>Periodicals Index Online</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - West</collection><collection>Primary Sources Access (Plan D) - International</collection><collection>Primary Sources Access & Build (Plan A) - MEA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Midwest</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Northeast</collection><collection>Primary Sources Access (Plan D) - Southeast</collection><collection>Primary Sources Access (Plan D) - North Central</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Southeast</collection><collection>Primary Sources Access (Plan D) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - UK / I</collection><collection>Primary Sources Access (Plan D) - Canada</collection><collection>Primary Sources Access (Plan D) - EMEALA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - North Central</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - International</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - International</collection><collection>Primary Sources Access (Plan D) - West</collection><collection>Periodicals Index Online Segments 1-50</collection><collection>Primary Sources Access (Plan D) - APAC</collection><collection>Primary Sources Access (Plan D) - Midwest</collection><collection>Primary Sources Access (Plan D) - MEA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Canada</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - UK / I</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - EMEALA</collection><collection>Primary Sources Access & Build (Plan A) - APAC</collection><collection>Primary Sources Access & Build (Plan A) - Canada</collection><collection>Primary Sources Access & Build (Plan A) - West</collection><collection>Primary Sources Access & Build (Plan A) - EMEALA</collection><collection>Primary Sources Access (Plan D) - Northeast</collection><collection>Primary Sources Access & Build (Plan A) - Midwest</collection><collection>Primary Sources Access & Build (Plan A) - North Central</collection><collection>Primary Sources Access & Build (Plan A) - Northeast</collection><collection>Primary Sources Access & Build (Plan A) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - Southeast</collection><collection>Primary Sources Access (Plan D) - UK / I</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - APAC</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - MEA</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Breier, Alan</au><au>Kestler, Lisa</au><au>Adler, Caleb</au><au>Elman, Igor</au><au>Wiesenfeld, Neil</au><au>Malhotra, Anil</au><au>Pickar, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dopamine D2 Receptor Density and Personal Detachment in Healthy Subjects</atitle><jtitle>The American journal of psychiatry</jtitle><addtitle>Am J Psychiatry</addtitle><date>1998-10</date><risdate>1998</risdate><volume>155</volume><issue>10</issue><spage>1440</spage><epage>1442</epage><pages>1440-1442</pages><issn>0002-953X</issn><eissn>1535-7228</eissn><coden>AJPSAO</coden><abstract>Objective:The purpose of this study was to examine the relationship between the personality trait involving personal detachment and dopamine D2 receptor specific binding in healthy subjects.Method:Eighteen adult subjects completed the Karolinska Scales of Personality and the Tridimensional Personality Questionnaire and participated in a study that used [11C]raclopride positron emission tomography (PET) to quantify striatal D2 receptor binding. Results:A significant relationship was found between D2 receptor specific binding and detachment scores on the Karolinska Scales of Personality but not between D2 receptor specific binding and attachment scores on the Tridimensional Personality Questionnaire. In an exploratory analysis, the authors found a significant relationship between binding and the sentimentality cluster on the Tridimensional Personality Questionnaire but on no other personality clusters scores on the Tridimensional Personality Questionnaire or Karolinska Scales of Personality.Conclusions:These findings replicate those of a recent report that personal detachment scores on the Karolinska Scales of Personality are related to dopamine D2 receptor density and extends this finding by suggesting that the relationship is relatively specific to the trait defined by the Karolinska Scales of Personality and does not generalize to other forms of detachment. Am J Psychiatry 1998; 155: 1440-1442</abstract><cop>Washington, DC</cop><pub>American Psychiatric Publishing</pub><pmid>9766779</pmid><doi>10.1176/ajp.155.10.1440</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-953X |
| ispartof | The American journal of psychiatry, 1998-10, Vol.155 (10), p.1440-1442 |
| issn | 0002-953X 1535-7228 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69945958 |
| source | MEDLINE; American Psychiatric Publishing Journals (1997-Present); Periodicals Index Online; Applied Social Sciences Index & Abstracts (ASSIA); EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Biological and medical sciences Carbon Radioisotopes Corpus Striatum - diagnostic imaging Corpus Striatum - metabolism Dopamine Dopamine Antagonists Female Fundamental and applied biological sciences. Psychology Health Status Humans Male Molecular biology Personality Personality - physiology Personality Assessment - statistics & numerical data Personality traits Personality. Affectivity Psychiatry Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Raclopride Receptor status Receptors, Dopamine D2 - metabolism Receptors, Dopamine D2 - physiology Relationship Salicylamides Social attachment Tomography, Emission-Computed |
| title | Dopamine D2 Receptor Density and Personal Detachment in Healthy Subjects |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T08%3A53%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dopamine%20D2%20Receptor%20Density%20and%20Personal%20Detachment%20in%20Healthy%20Subjects&rft.jtitle=The%20American%20journal%20of%20psychiatry&rft.au=Breier,%20Alan&rft.date=1998-10&rft.volume=155&rft.issue=10&rft.spage=1440&rft.epage=1442&rft.pages=1440-1442&rft.issn=0002-953X&rft.eissn=1535-7228&rft.coden=AJPSAO&rft_id=info:doi/10.1176/ajp.155.10.1440&rft_dat=%3Cproquest_pubme%3E57375285%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1518397676&rft_id=info:pmid/9766779&rfr_iscdi=true |