Cytogenetic clonality analysis in monosomy 7 associated with juvenile myelomonocytic leukemia: clonality in B and NK cells, but not in T cells
It remains unclear which lymphoid lineages are involved in juvenile myelomonocytic leukemia (JMML). We report a JMML patient who acquired monosomy 7 after intensive chemotherapy. In this case, the expression of monosomy 7 was analyzed in T, B and natural killer (NK) cells highly purified from periph...
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| Veröffentlicht in: | Leukemia research 1998-10, Vol.22 (10), p.887-892 |
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| container_title | Leukemia research |
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| creator | Nakazawa, Takayuki Koike, Kenichi Agematsu, Kazunaga Itoh, Susumu Hagimoto, Rokuro Kitazawa, Yumi Higuchi, Tsukasa Sawai, Nobukuni Matsui, Hiroko Komiyama, Atsushi |
| description | It remains unclear which lymphoid lineages are involved in juvenile myelomonocytic leukemia (JMML). We report a JMML patient who acquired monosomy 7 after intensive chemotherapy. In this case, the expression of monosomy 7 was analyzed in T, B and natural killer (NK) cells highly purified from peripheral blood mononuclear cells of the patient. The fluorescence in situ hybridization method revealed the expression of monosomy 7 in B cells, but not T cells. Half of the NK cells expressed monosomy 7; when NK cells were divided into CD2
− and CD2
+ populations, this abnormality was positive in 91.1% of CD2
− NK cells but in only 14.7% of CD2
+ NK cells. These results suggest that, in this JMML patient who acquired monosomy 7 after intensive chemotherapy, B cells and half of NK cells, but not T cells, have monosomy 7. |
| doi_str_mv | 10.1016/S0145-2126(98)00090-3 |
| format | Article |
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− and CD2
+ populations, this abnormality was positive in 91.1% of CD2
− NK cells but in only 14.7% of CD2
+ NK cells. These results suggest that, in this JMML patient who acquired monosomy 7 after intensive chemotherapy, B cells and half of NK cells, but not T cells, have monosomy 7.</description><identifier>ISSN: 0145-2126</identifier><identifier>EISSN: 1873-5835</identifier><identifier>DOI: 10.1016/S0145-2126(98)00090-3</identifier><identifier>PMID: 9766748</identifier><identifier>CODEN: LEREDD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>B-Lymphocytes ; Biological and medical sciences ; CD2 Antigens - blood ; Cell Lineage ; Chromosomes, Human, Pair 7 ; Clonality ; Clone Cells ; Fluorescence in situ hybridization ; Hematologic and hematopoietic diseases ; Humans ; In Situ Hybridization, Fluorescence ; Infant, Newborn ; Juvenile myelomonocytic leukemia ; Karyotyping ; Killer Cells, Natural ; Leukemia, Myelomonocytic, Chronic - genetics ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Medical sciences ; Monosomy ; Monosomy 7 ; T-Lymphocytes</subject><ispartof>Leukemia research, 1998-10, Vol.22 (10), p.887-892</ispartof><rights>1998 Elsevier Science Ltd</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-e24f9607e1025e0b9a3b6d1a2f21a92e3cc7f24b1a36a05fbc937f141f7e5863</citedby><cites>FETCH-LOGICAL-c420t-e24f9607e1025e0b9a3b6d1a2f21a92e3cc7f24b1a36a05fbc937f141f7e5863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0145212698000903$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2378732$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9766748$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakazawa, Takayuki</creatorcontrib><creatorcontrib>Koike, Kenichi</creatorcontrib><creatorcontrib>Agematsu, Kazunaga</creatorcontrib><creatorcontrib>Itoh, Susumu</creatorcontrib><creatorcontrib>Hagimoto, Rokuro</creatorcontrib><creatorcontrib>Kitazawa, Yumi</creatorcontrib><creatorcontrib>Higuchi, Tsukasa</creatorcontrib><creatorcontrib>Sawai, Nobukuni</creatorcontrib><creatorcontrib>Matsui, Hiroko</creatorcontrib><creatorcontrib>Komiyama, Atsushi</creatorcontrib><title>Cytogenetic clonality analysis in monosomy 7 associated with juvenile myelomonocytic leukemia: clonality in B and NK cells, but not in T cells</title><title>Leukemia research</title><addtitle>Leuk Res</addtitle><description>It remains unclear which lymphoid lineages are involved in juvenile myelomonocytic leukemia (JMML). We report a JMML patient who acquired monosomy 7 after intensive chemotherapy. In this case, the expression of monosomy 7 was analyzed in T, B and natural killer (NK) cells highly purified from peripheral blood mononuclear cells of the patient. The fluorescence in situ hybridization method revealed the expression of monosomy 7 in B cells, but not T cells. Half of the NK cells expressed monosomy 7; when NK cells were divided into CD2
− and CD2
+ populations, this abnormality was positive in 91.1% of CD2
− NK cells but in only 14.7% of CD2
+ NK cells. These results suggest that, in this JMML patient who acquired monosomy 7 after intensive chemotherapy, B cells and half of NK cells, but not T cells, have monosomy 7.</description><subject>B-Lymphocytes</subject><subject>Biological and medical sciences</subject><subject>CD2 Antigens - blood</subject><subject>Cell Lineage</subject><subject>Chromosomes, Human, Pair 7</subject><subject>Clonality</subject><subject>Clone Cells</subject><subject>Fluorescence in situ hybridization</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Infant, Newborn</subject><subject>Juvenile myelomonocytic leukemia</subject><subject>Karyotyping</subject><subject>Killer Cells, Natural</subject><subject>Leukemia, Myelomonocytic, Chronic - genetics</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Monosomy</subject><subject>Monosomy 7</subject><subject>T-Lymphocytes</subject><issn>0145-2126</issn><issn>1873-5835</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EKkvhJ1TyASEqEfBX7JgLoiu-RAUH9m45zhhckriNnaL8CX4zTne14tbTSJ5n3hn5QeiMkteUUPnmB6Girhhl8qVuzgkhmlT8AdrQRvGqbnj9EG2OyGP0JKWrAtWa6hN0opWUSjQb9He75PgTRsjBYdfH0fYhL9iWuqSQcBjxEMeY4rBghW1K0QWbocN_Qv6Fr-ZbGEMPeFigjyvoljWoh_k3DMG-_S-yJF2U3A5_-4od9H16hds54zHmtbXbvz1Fj7ztEzw71FO0-_hht_1cXX7_9GX7_rJygpFcARNeS6KAElYDabXlreyoZZ5Rqxlw55RnoqWWS0tq3zrNlaeCegV1I_kperGPvZ7izQwpmyGk9QA7QpyTkVqLuhHiXpAqKnXDWAHrPeimmNIE3lxPYbDTYigxqy9z58usMoxuzJ0vw8vc2WHB3A7QHacOgkr_-aFvk7O9n-zoQjpijKuie13_bo9B-bTbAJNJLsDooAsTuGy6GO455B-IHLNQ</recordid><startdate>19981001</startdate><enddate>19981001</enddate><creator>Nakazawa, Takayuki</creator><creator>Koike, Kenichi</creator><creator>Agematsu, Kazunaga</creator><creator>Itoh, Susumu</creator><creator>Hagimoto, Rokuro</creator><creator>Kitazawa, Yumi</creator><creator>Higuchi, Tsukasa</creator><creator>Sawai, Nobukuni</creator><creator>Matsui, Hiroko</creator><creator>Komiyama, Atsushi</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19981001</creationdate><title>Cytogenetic clonality analysis in monosomy 7 associated with juvenile myelomonocytic leukemia: clonality in B and NK cells, but not in T cells</title><author>Nakazawa, Takayuki ; Koike, Kenichi ; Agematsu, Kazunaga ; Itoh, Susumu ; Hagimoto, Rokuro ; Kitazawa, Yumi ; Higuchi, Tsukasa ; Sawai, Nobukuni ; Matsui, Hiroko ; Komiyama, Atsushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-e24f9607e1025e0b9a3b6d1a2f21a92e3cc7f24b1a36a05fbc937f141f7e5863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>B-Lymphocytes</topic><topic>Biological and medical sciences</topic><topic>CD2 Antigens - blood</topic><topic>Cell Lineage</topic><topic>Chromosomes, Human, Pair 7</topic><topic>Clonality</topic><topic>Clone Cells</topic><topic>Fluorescence in situ hybridization</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Infant, Newborn</topic><topic>Juvenile myelomonocytic leukemia</topic><topic>Karyotyping</topic><topic>Killer Cells, Natural</topic><topic>Leukemia, Myelomonocytic, Chronic - genetics</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Monosomy</topic><topic>Monosomy 7</topic><topic>T-Lymphocytes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakazawa, Takayuki</creatorcontrib><creatorcontrib>Koike, Kenichi</creatorcontrib><creatorcontrib>Agematsu, Kazunaga</creatorcontrib><creatorcontrib>Itoh, Susumu</creatorcontrib><creatorcontrib>Hagimoto, Rokuro</creatorcontrib><creatorcontrib>Kitazawa, Yumi</creatorcontrib><creatorcontrib>Higuchi, Tsukasa</creatorcontrib><creatorcontrib>Sawai, Nobukuni</creatorcontrib><creatorcontrib>Matsui, Hiroko</creatorcontrib><creatorcontrib>Komiyama, Atsushi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Leukemia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakazawa, Takayuki</au><au>Koike, Kenichi</au><au>Agematsu, Kazunaga</au><au>Itoh, Susumu</au><au>Hagimoto, Rokuro</au><au>Kitazawa, Yumi</au><au>Higuchi, Tsukasa</au><au>Sawai, Nobukuni</au><au>Matsui, Hiroko</au><au>Komiyama, Atsushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytogenetic clonality analysis in monosomy 7 associated with juvenile myelomonocytic leukemia: clonality in B and NK cells, but not in T cells</atitle><jtitle>Leukemia research</jtitle><addtitle>Leuk Res</addtitle><date>1998-10-01</date><risdate>1998</risdate><volume>22</volume><issue>10</issue><spage>887</spage><epage>892</epage><pages>887-892</pages><issn>0145-2126</issn><eissn>1873-5835</eissn><coden>LEREDD</coden><abstract>It remains unclear which lymphoid lineages are involved in juvenile myelomonocytic leukemia (JMML). We report a JMML patient who acquired monosomy 7 after intensive chemotherapy. In this case, the expression of monosomy 7 was analyzed in T, B and natural killer (NK) cells highly purified from peripheral blood mononuclear cells of the patient. The fluorescence in situ hybridization method revealed the expression of monosomy 7 in B cells, but not T cells. Half of the NK cells expressed monosomy 7; when NK cells were divided into CD2
− and CD2
+ populations, this abnormality was positive in 91.1% of CD2
− NK cells but in only 14.7% of CD2
+ NK cells. These results suggest that, in this JMML patient who acquired monosomy 7 after intensive chemotherapy, B cells and half of NK cells, but not T cells, have monosomy 7.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>9766748</pmid><doi>10.1016/S0145-2126(98)00090-3</doi><tpages>6</tpages></addata></record> |
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| ispartof | Leukemia research, 1998-10, Vol.22 (10), p.887-892 |
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| subjects | B-Lymphocytes Biological and medical sciences CD2 Antigens - blood Cell Lineage Chromosomes, Human, Pair 7 Clonality Clone Cells Fluorescence in situ hybridization Hematologic and hematopoietic diseases Humans In Situ Hybridization, Fluorescence Infant, Newborn Juvenile myelomonocytic leukemia Karyotyping Killer Cells, Natural Leukemia, Myelomonocytic, Chronic - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Monosomy Monosomy 7 T-Lymphocytes |
| title | Cytogenetic clonality analysis in monosomy 7 associated with juvenile myelomonocytic leukemia: clonality in B and NK cells, but not in T cells |
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