Sublocalization of putative tumor suppressor gene loci on chromosome arm 14q in neuroblastoma
RFLP and microsatellite analysis with 23 polymorphic markers spanning the entire long arm of chromosome 14 in 108 neuroblastomas showed allelic loss in 19 out of 107 (18%) informative tumors, placing 14q among the most frequently affected chromosomal regions in neuroblastoma. One minimal deletion re...
Gespeichert in:
| Veröffentlicht in: | Genes chromosomes & cancer 1999-09, Vol.26 (1), p.40-46 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 46 |
|---|---|
| container_issue | 1 |
| container_start_page | 40 |
| container_title | Genes chromosomes & cancer |
| container_volume | 26 |
| creator | Theobald, Marco Christiansen, Holger Schmidt, Anke Melekian, Badrig Wolkewitz, Nicole Christiansen, Nina M. Brinkschmidt, Christian Berthold, Frank Lampert, Fritz |
| description | RFLP and microsatellite analysis with 23 polymorphic markers spanning the entire long arm of chromosome 14 in 108 neuroblastomas showed allelic loss in 19 out of 107 (18%) informative tumors, placing 14q among the most frequently affected chromosomal regions in neuroblastoma. One minimal deletion region could be sublocalized in 17 of 19 cases between markers D14S1 and D14S16, and a second one between markers D14S17 and D14S23 in band 14q32. Furthermore, breakpoints in bands 14q23 and 14q12 were detected. These results suggest the presence of at least two putative tumor suppressor gene loci on chromosome 14. Survival analyses revealed no prognostic impact of allelic loss of 14q in neuroblastoma. Genes Chromosomes Cancer 26:40–46, 1999. © 1999 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1098-2264(199909)26:1<40::AID-GCC6>3.0.CO;2-W |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69943937</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69943937</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3976-5fd240d088ebf3f7c42c406114257c5a3943529ade51b19736e999c563d1630c3</originalsourceid><addsrcrecordid>eNp9kF1v0zAYhSMEYmPwF5Cv0HaR4u_UHUKawlaqTbRSQb1CrxzHgUBSZ3YCG78eh0wDCcSVj-Wj51hPkpwSPCMY05fH21W-OiFYzVNKJT8mSimsTqhckFccLxZnqzfpMs_lazbDs3x9StPdg-Twvv9wzFzELLKD5EkIXzDGkinxODmIDzxu8MPk43YoGmd0U__Qfe32yFWoG_qYv1nUD63zKAxd520IMX6ye4tivUaxaT5717rgWou0bxHh16jeo70dvCsaHXrX6qfJo0o3wT67O4-SDxfn7_O36dV6ucrPrlLDVCZTUZWU4xLP57aoWJUZTg3HkhAe_26EZoozQZUurSAFURmTNrowQrKSSIYNO0peTNzOu-vBhh7aOhjbNHpv3RBAqkhQLIvF7VQ03oXgbQWdr1vtb4FgGK0DjNZhtAijRZisA5VAgGOAaB1G68AAQ74GCrtIfX43PxStLf9gTpp_z36vG3v71-b_J_-x-OseqelErUNvb-6p2n8FmbFMwO7dEi7FZrOUlxewYT8BxfarRw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69943937</pqid></control><display><type>article</type><title>Sublocalization of putative tumor suppressor gene loci on chromosome arm 14q in neuroblastoma</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Theobald, Marco ; Christiansen, Holger ; Schmidt, Anke ; Melekian, Badrig ; Wolkewitz, Nicole ; Christiansen, Nina M. ; Brinkschmidt, Christian ; Berthold, Frank ; Lampert, Fritz</creator><creatorcontrib>Theobald, Marco ; Christiansen, Holger ; Schmidt, Anke ; Melekian, Badrig ; Wolkewitz, Nicole ; Christiansen, Nina M. ; Brinkschmidt, Christian ; Berthold, Frank ; Lampert, Fritz</creatorcontrib><description>RFLP and microsatellite analysis with 23 polymorphic markers spanning the entire long arm of chromosome 14 in 108 neuroblastomas showed allelic loss in 19 out of 107 (18%) informative tumors, placing 14q among the most frequently affected chromosomal regions in neuroblastoma. One minimal deletion region could be sublocalized in 17 of 19 cases between markers D14S1 and D14S16, and a second one between markers D14S17 and D14S23 in band 14q32. Furthermore, breakpoints in bands 14q23 and 14q12 were detected. These results suggest the presence of at least two putative tumor suppressor gene loci on chromosome 14. Survival analyses revealed no prognostic impact of allelic loss of 14q in neuroblastoma. Genes Chromosomes Cancer 26:40–46, 1999. © 1999 Wiley‐Liss, Inc.</description><identifier>ISSN: 1045-2257</identifier><identifier>EISSN: 1098-2264</identifier><identifier>DOI: 10.1002/(SICI)1098-2264(199909)26:1<40::AID-GCC6>3.0.CO;2-W</identifier><identifier>PMID: 10441004</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Chromosome Mapping ; Chromosomes, Human, Pair 1 - genetics ; Chromosomes, Human, Pair 14 - genetics ; DNA, Neoplasm - genetics ; Gene Amplification ; Genes, myc - genetics ; Genes, Tumor Suppressor - genetics ; Humans ; Loss of Heterozygosity ; Microsatellite Repeats ; Neuroblastoma - genetics ; Neuroblastoma - pathology ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Prognosis ; Survival Analysis ; Time Factors</subject><ispartof>Genes chromosomes & cancer, 1999-09, Vol.26 (1), p.40-46</ispartof><rights>Copyright © 1999 Wiley‐Liss, Inc.</rights><rights>Copyright 1999 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3976-5fd240d088ebf3f7c42c406114257c5a3943529ade51b19736e999c563d1630c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291098-2264%28199909%2926%3A1%3C40%3A%3AAID-GCC6%3E3.0.CO%3B2-W$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291098-2264%28199909%2926%3A1%3C40%3A%3AAID-GCC6%3E3.0.CO%3B2-W$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10441004$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Theobald, Marco</creatorcontrib><creatorcontrib>Christiansen, Holger</creatorcontrib><creatorcontrib>Schmidt, Anke</creatorcontrib><creatorcontrib>Melekian, Badrig</creatorcontrib><creatorcontrib>Wolkewitz, Nicole</creatorcontrib><creatorcontrib>Christiansen, Nina M.</creatorcontrib><creatorcontrib>Brinkschmidt, Christian</creatorcontrib><creatorcontrib>Berthold, Frank</creatorcontrib><creatorcontrib>Lampert, Fritz</creatorcontrib><title>Sublocalization of putative tumor suppressor gene loci on chromosome arm 14q in neuroblastoma</title><title>Genes chromosomes & cancer</title><addtitle>Genes Chromosom. Cancer</addtitle><description>RFLP and microsatellite analysis with 23 polymorphic markers spanning the entire long arm of chromosome 14 in 108 neuroblastomas showed allelic loss in 19 out of 107 (18%) informative tumors, placing 14q among the most frequently affected chromosomal regions in neuroblastoma. One minimal deletion region could be sublocalized in 17 of 19 cases between markers D14S1 and D14S16, and a second one between markers D14S17 and D14S23 in band 14q32. Furthermore, breakpoints in bands 14q23 and 14q12 were detected. These results suggest the presence of at least two putative tumor suppressor gene loci on chromosome 14. Survival analyses revealed no prognostic impact of allelic loss of 14q in neuroblastoma. Genes Chromosomes Cancer 26:40–46, 1999. © 1999 Wiley‐Liss, Inc.</description><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 1 - genetics</subject><subject>Chromosomes, Human, Pair 14 - genetics</subject><subject>DNA, Neoplasm - genetics</subject><subject>Gene Amplification</subject><subject>Genes, myc - genetics</subject><subject>Genes, Tumor Suppressor - genetics</subject><subject>Humans</subject><subject>Loss of Heterozygosity</subject><subject>Microsatellite Repeats</subject><subject>Neuroblastoma - genetics</subject><subject>Neuroblastoma - pathology</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Prognosis</subject><subject>Survival Analysis</subject><subject>Time Factors</subject><issn>1045-2257</issn><issn>1098-2264</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1v0zAYhSMEYmPwF5Cv0HaR4u_UHUKawlaqTbRSQb1CrxzHgUBSZ3YCG78eh0wDCcSVj-Wj51hPkpwSPCMY05fH21W-OiFYzVNKJT8mSimsTqhckFccLxZnqzfpMs_lazbDs3x9StPdg-Twvv9wzFzELLKD5EkIXzDGkinxODmIDzxu8MPk43YoGmd0U__Qfe32yFWoG_qYv1nUD63zKAxd520IMX6ye4tivUaxaT5717rgWou0bxHh16jeo70dvCsaHXrX6qfJo0o3wT67O4-SDxfn7_O36dV6ucrPrlLDVCZTUZWU4xLP57aoWJUZTg3HkhAe_26EZoozQZUurSAFURmTNrowQrKSSIYNO0peTNzOu-vBhh7aOhjbNHpv3RBAqkhQLIvF7VQ03oXgbQWdr1vtb4FgGK0DjNZhtAijRZisA5VAgGOAaB1G68AAQ74GCrtIfX43PxStLf9gTpp_z36vG3v71-b_J_-x-OseqelErUNvb-6p2n8FmbFMwO7dEi7FZrOUlxewYT8BxfarRw</recordid><startdate>199909</startdate><enddate>199909</enddate><creator>Theobald, Marco</creator><creator>Christiansen, Holger</creator><creator>Schmidt, Anke</creator><creator>Melekian, Badrig</creator><creator>Wolkewitz, Nicole</creator><creator>Christiansen, Nina M.</creator><creator>Brinkschmidt, Christian</creator><creator>Berthold, Frank</creator><creator>Lampert, Fritz</creator><general>John Wiley & Sons, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199909</creationdate><title>Sublocalization of putative tumor suppressor gene loci on chromosome arm 14q in neuroblastoma</title><author>Theobald, Marco ; Christiansen, Holger ; Schmidt, Anke ; Melekian, Badrig ; Wolkewitz, Nicole ; Christiansen, Nina M. ; Brinkschmidt, Christian ; Berthold, Frank ; Lampert, Fritz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3976-5fd240d088ebf3f7c42c406114257c5a3943529ade51b19736e999c563d1630c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 1 - genetics</topic><topic>Chromosomes, Human, Pair 14 - genetics</topic><topic>DNA, Neoplasm - genetics</topic><topic>Gene Amplification</topic><topic>Genes, myc - genetics</topic><topic>Genes, Tumor Suppressor - genetics</topic><topic>Humans</topic><topic>Loss of Heterozygosity</topic><topic>Microsatellite Repeats</topic><topic>Neuroblastoma - genetics</topic><topic>Neuroblastoma - pathology</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Prognosis</topic><topic>Survival Analysis</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Theobald, Marco</creatorcontrib><creatorcontrib>Christiansen, Holger</creatorcontrib><creatorcontrib>Schmidt, Anke</creatorcontrib><creatorcontrib>Melekian, Badrig</creatorcontrib><creatorcontrib>Wolkewitz, Nicole</creatorcontrib><creatorcontrib>Christiansen, Nina M.</creatorcontrib><creatorcontrib>Brinkschmidt, Christian</creatorcontrib><creatorcontrib>Berthold, Frank</creatorcontrib><creatorcontrib>Lampert, Fritz</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Genes chromosomes & cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Theobald, Marco</au><au>Christiansen, Holger</au><au>Schmidt, Anke</au><au>Melekian, Badrig</au><au>Wolkewitz, Nicole</au><au>Christiansen, Nina M.</au><au>Brinkschmidt, Christian</au><au>Berthold, Frank</au><au>Lampert, Fritz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sublocalization of putative tumor suppressor gene loci on chromosome arm 14q in neuroblastoma</atitle><jtitle>Genes chromosomes & cancer</jtitle><addtitle>Genes Chromosom. Cancer</addtitle><date>1999-09</date><risdate>1999</risdate><volume>26</volume><issue>1</issue><spage>40</spage><epage>46</epage><pages>40-46</pages><issn>1045-2257</issn><eissn>1098-2264</eissn><abstract>RFLP and microsatellite analysis with 23 polymorphic markers spanning the entire long arm of chromosome 14 in 108 neuroblastomas showed allelic loss in 19 out of 107 (18%) informative tumors, placing 14q among the most frequently affected chromosomal regions in neuroblastoma. One minimal deletion region could be sublocalized in 17 of 19 cases between markers D14S1 and D14S16, and a second one between markers D14S17 and D14S23 in band 14q32. Furthermore, breakpoints in bands 14q23 and 14q12 were detected. These results suggest the presence of at least two putative tumor suppressor gene loci on chromosome 14. Survival analyses revealed no prognostic impact of allelic loss of 14q in neuroblastoma. Genes Chromosomes Cancer 26:40–46, 1999. © 1999 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>10441004</pmid><doi>10.1002/(SICI)1098-2264(199909)26:1<40::AID-GCC6>3.0.CO;2-W</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1045-2257 |
| ispartof | Genes chromosomes & cancer, 1999-09, Vol.26 (1), p.40-46 |
| issn | 1045-2257 1098-2264 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69943937 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Chromosome Mapping Chromosomes, Human, Pair 1 - genetics Chromosomes, Human, Pair 14 - genetics DNA, Neoplasm - genetics Gene Amplification Genes, myc - genetics Genes, Tumor Suppressor - genetics Humans Loss of Heterozygosity Microsatellite Repeats Neuroblastoma - genetics Neuroblastoma - pathology Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Prognosis Survival Analysis Time Factors |
| title | Sublocalization of putative tumor suppressor gene loci on chromosome arm 14q in neuroblastoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T18%3A16%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sublocalization%20of%20putative%20tumor%20suppressor%20gene%20loci%20on%20chromosome%20arm%2014q%20in%20neuroblastoma&rft.jtitle=Genes%20chromosomes%20&%20cancer&rft.au=Theobald,%20Marco&rft.date=1999-09&rft.volume=26&rft.issue=1&rft.spage=40&rft.epage=46&rft.pages=40-46&rft.issn=1045-2257&rft.eissn=1098-2264&rft_id=info:doi/10.1002/(SICI)1098-2264(199909)26:1%3C40::AID-GCC6%3E3.0.CO;2-W&rft_dat=%3Cproquest_cross%3E69943937%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69943937&rft_id=info:pmid/10441004&rfr_iscdi=true |