Parathyroid Hormone Stimulates TRANCE and Inhibits Osteoprotegerin Messenger Ribonucleic Acid Expression in Murine Bone Marrow Cultures: Correlation with Osteoclast-Like Cell Formation

Abstract We studied the effects of PTH on the expression of tumor necrosis factor-related activation-induced cytokine (TRANCE), osteoprotegerin (OPG), and receptor activator of NF κB (RANK) messenger RNA (mRNA) in cultured murine bone marrow, calvaria, and osteoblasts. TRANCE, OPG, and RANK are rece...

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Veröffentlicht in:	Endocrinology (Philadelphia) 1999-08, Vol.140 (8), p.3552-3561
Hauptverfasser:	Lee, Sun-Kyeong, Lorenzo, Joseph A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone growth Bone marrow Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism Bone resorption Calvaria Carrier Proteins - genetics Cell activation Cell culture Cell Differentiation - drug effects Cells, Cultured Gene expression Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Glycoproteins - genetics Kinetics Membrane Glycoproteins - genetics Mice Mice, Inbred C57BL NF-^KB protein NF-kappa B - genetics Osteoblasts Osteoclasts - cytology Osteoclasts - drug effects Osteoclasts - metabolism Osteoprotegerin Parathyroid hormone Parathyroid Hormone - pharmacology RANK Ligand RANK protein Receptor Activator of Nuclear Factor-kappa B Receptors, Cytoplasmic and Nuclear Receptors, Tumor Necrosis Factor - genetics RNA, Messenger - genetics Skull Space life sciences Time dependence Time Factors TRANCE protein Transcription, Genetic - drug effects Transcription, Genetic - physiology Tumor Necrosis Factor-alpha - genetics tumor necrosis factor-related activation-induced cytokine
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