T- helper 1 and 2 cytokine assay in patients with common variable immunodeficiency
Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by decreased immunoglobulin levels in serum and increased susceptibility to recurrent infections, autoimmunity, and malignancy. The pathogenesis of CVID is still unknown. This study was performed to investig...
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| Veröffentlicht in: | Journal of investigational allergology & clinical immunology 2008, Vol.18 (6), p.449-453 |
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| container_title | Journal of investigational allergology & clinical immunology |
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| creator | Rezaei, N Aghamohammadi, A Kardar, G A Nourizadeh, M Pourpak, Z |
| description | Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by decreased immunoglobulin levels in serum and increased susceptibility to recurrent infections, autoimmunity, and malignancy. The pathogenesis of CVID is still unknown.
This study was performed to investigate T-helper (T(H)) 1 and 2 cytokine levels in patients with CVID.
Twenty-four cases of CVID were studied. Cytokine levels of interleukin (IL)-2, IL-4, IL-10, and interferon gamma were measured in the serum of the patients and compared with those of healthy controls.
T(H)2 cytokine levels (IL-4 and IL-10) were significantly higher in the patient group than in the controls (median: 64.5 vs 0.0 pg/mL, P=.016 for IL-4 and 321.1 vs. 0.0 pg/mL, P=.001 for IL-10). However, there were no significant differences in T(H)1 cytokines between the 2 groups (median, 116.5 vs. 104.5 pg/mL, P=.22 for IL-2 and 50.5 vs. 42.3 pg/mL, P=.32 for IFN-gamma).
Increased levels of IL-4 and IL-10 could indicate high activation of T(H)2 lymphocytes in this group of patients and consequently supports the concept of a bias towards T(H)2-type responses. |
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This study was performed to investigate T-helper (T(H)) 1 and 2 cytokine levels in patients with CVID.
Twenty-four cases of CVID were studied. Cytokine levels of interleukin (IL)-2, IL-4, IL-10, and interferon gamma were measured in the serum of the patients and compared with those of healthy controls.
T(H)2 cytokine levels (IL-4 and IL-10) were significantly higher in the patient group than in the controls (median: 64.5 vs 0.0 pg/mL, P=.016 for IL-4 and 321.1 vs. 0.0 pg/mL, P=.001 for IL-10). However, there were no significant differences in T(H)1 cytokines between the 2 groups (median, 116.5 vs. 104.5 pg/mL, P=.22 for IL-2 and 50.5 vs. 42.3 pg/mL, P=.32 for IFN-gamma).
Increased levels of IL-4 and IL-10 could indicate high activation of T(H)2 lymphocytes in this group of patients and consequently supports the concept of a bias towards T(H)2-type responses.</description><identifier>ISSN: 1018-9068</identifier><identifier>PMID: 19123436</identifier><language>eng</language><publisher>Spain</publisher><subject>Adolescent ; Child ; Common Variable Immunodeficiency - blood ; Common Variable Immunodeficiency - immunology ; Cytokines - biosynthesis ; Cytokines - blood ; Female ; Humans ; Immunoassay ; Interferon-gamma - biosynthesis ; Interferon-gamma - blood ; Interleukin-10 - biosynthesis ; Interleukin-10 - blood ; Interleukin-2 - biosynthesis ; Interleukin-2 - blood ; Interleukin-4 - biosynthesis ; Interleukin-4 - blood ; Male ; Th1 Cells - immunology ; Th2 Cells - immunology ; Young Adult</subject><ispartof>Journal of investigational allergology & clinical immunology, 2008, Vol.18 (6), p.449-453</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4022</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19123436$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rezaei, N</creatorcontrib><creatorcontrib>Aghamohammadi, A</creatorcontrib><creatorcontrib>Kardar, G A</creatorcontrib><creatorcontrib>Nourizadeh, M</creatorcontrib><creatorcontrib>Pourpak, Z</creatorcontrib><title>T- helper 1 and 2 cytokine assay in patients with common variable immunodeficiency</title><title>Journal of investigational allergology & clinical immunology</title><addtitle>J Investig Allergol Clin Immunol</addtitle><description>Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by decreased immunoglobulin levels in serum and increased susceptibility to recurrent infections, autoimmunity, and malignancy. The pathogenesis of CVID is still unknown.
This study was performed to investigate T-helper (T(H)) 1 and 2 cytokine levels in patients with CVID.
Twenty-four cases of CVID were studied. Cytokine levels of interleukin (IL)-2, IL-4, IL-10, and interferon gamma were measured in the serum of the patients and compared with those of healthy controls.
T(H)2 cytokine levels (IL-4 and IL-10) were significantly higher in the patient group than in the controls (median: 64.5 vs 0.0 pg/mL, P=.016 for IL-4 and 321.1 vs. 0.0 pg/mL, P=.001 for IL-10). However, there were no significant differences in T(H)1 cytokines between the 2 groups (median, 116.5 vs. 104.5 pg/mL, P=.22 for IL-2 and 50.5 vs. 42.3 pg/mL, P=.32 for IFN-gamma).
Increased levels of IL-4 and IL-10 could indicate high activation of T(H)2 lymphocytes in this group of patients and consequently supports the concept of a bias towards T(H)2-type responses.</description><subject>Adolescent</subject><subject>Child</subject><subject>Common Variable Immunodeficiency - blood</subject><subject>Common Variable Immunodeficiency - immunology</subject><subject>Cytokines - biosynthesis</subject><subject>Cytokines - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Interferon-gamma - blood</subject><subject>Interleukin-10 - biosynthesis</subject><subject>Interleukin-10 - blood</subject><subject>Interleukin-2 - biosynthesis</subject><subject>Interleukin-2 - blood</subject><subject>Interleukin-4 - biosynthesis</subject><subject>Interleukin-4 - blood</subject><subject>Male</subject><subject>Th1 Cells - immunology</subject><subject>Th2 Cells - immunology</subject><subject>Young Adult</subject><issn>1018-9068</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo10E1Lw0AUheFZKLZW_4LMyl1gPpLJ3KUUv6AgSF2Hm8kNHc1MYiZR8u8t2K7O5uEs3gu2lkLaDISxK3ad0qcQujS2vGIrCVLpXJs1e99n_EDdQCOXHGPDFXfL1H_5SBxTwoX7yAecPMUp8V8_HbjrQ-gj_8HRY90R9yHMsW-o9e6o3HLDLlvsEt2edsM-nh7325ds9_b8un3YZYMSMGU1iFZbBUqrvAXUYKgQbamVk6CptQ1QI0WhayOsKgUog9aWWBO4Om8Q9Ibd__8OY_89U5qq4JOjrsNI_ZwqA5DLQssjvDvBuQ7UVMPoA45Lda6g_wCpiVcs</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Rezaei, N</creator><creator>Aghamohammadi, A</creator><creator>Kardar, G A</creator><creator>Nourizadeh, M</creator><creator>Pourpak, Z</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>T- helper 1 and 2 cytokine assay in patients with common variable immunodeficiency</title><author>Rezaei, N ; Aghamohammadi, A ; Kardar, G A ; Nourizadeh, M ; Pourpak, Z</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p209t-b90f38292324f9a396e50f732c193ef8d9ed1053b608270926a887abe9cb4da93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Common Variable Immunodeficiency - blood</topic><topic>Common Variable Immunodeficiency - immunology</topic><topic>Cytokines - biosynthesis</topic><topic>Cytokines - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Interferon-gamma - biosynthesis</topic><topic>Interferon-gamma - blood</topic><topic>Interleukin-10 - biosynthesis</topic><topic>Interleukin-10 - blood</topic><topic>Interleukin-2 - biosynthesis</topic><topic>Interleukin-2 - blood</topic><topic>Interleukin-4 - biosynthesis</topic><topic>Interleukin-4 - blood</topic><topic>Male</topic><topic>Th1 Cells - immunology</topic><topic>Th2 Cells - immunology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rezaei, N</creatorcontrib><creatorcontrib>Aghamohammadi, A</creatorcontrib><creatorcontrib>Kardar, G A</creatorcontrib><creatorcontrib>Nourizadeh, M</creatorcontrib><creatorcontrib>Pourpak, Z</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of investigational allergology & clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rezaei, N</au><au>Aghamohammadi, A</au><au>Kardar, G A</au><au>Nourizadeh, M</au><au>Pourpak, Z</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>T- helper 1 and 2 cytokine assay in patients with common variable immunodeficiency</atitle><jtitle>Journal of investigational allergology & clinical immunology</jtitle><addtitle>J Investig Allergol Clin Immunol</addtitle><date>2008</date><risdate>2008</risdate><volume>18</volume><issue>6</issue><spage>449</spage><epage>453</epage><pages>449-453</pages><issn>1018-9068</issn><abstract>Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by decreased immunoglobulin levels in serum and increased susceptibility to recurrent infections, autoimmunity, and malignancy. The pathogenesis of CVID is still unknown.
This study was performed to investigate T-helper (T(H)) 1 and 2 cytokine levels in patients with CVID.
Twenty-four cases of CVID were studied. Cytokine levels of interleukin (IL)-2, IL-4, IL-10, and interferon gamma were measured in the serum of the patients and compared with those of healthy controls.
T(H)2 cytokine levels (IL-4 and IL-10) were significantly higher in the patient group than in the controls (median: 64.5 vs 0.0 pg/mL, P=.016 for IL-4 and 321.1 vs. 0.0 pg/mL, P=.001 for IL-10). However, there were no significant differences in T(H)1 cytokines between the 2 groups (median, 116.5 vs. 104.5 pg/mL, P=.22 for IL-2 and 50.5 vs. 42.3 pg/mL, P=.32 for IFN-gamma).
Increased levels of IL-4 and IL-10 could indicate high activation of T(H)2 lymphocytes in this group of patients and consequently supports the concept of a bias towards T(H)2-type responses.</abstract><cop>Spain</cop><pmid>19123436</pmid><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Child Common Variable Immunodeficiency - blood Common Variable Immunodeficiency - immunology Cytokines - biosynthesis Cytokines - blood Female Humans Immunoassay Interferon-gamma - biosynthesis Interferon-gamma - blood Interleukin-10 - biosynthesis Interleukin-10 - blood Interleukin-2 - biosynthesis Interleukin-2 - blood Interleukin-4 - biosynthesis Interleukin-4 - blood Male Th1 Cells - immunology Th2 Cells - immunology Young Adult |
| title | T- helper 1 and 2 cytokine assay in patients with common variable immunodeficiency |
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