The zinc finger protein a20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases

A20 is a Cys2/Cys2 zinc finger protein which is induced by a variety of inflammatory stimuli and which has been characterized as an inhibitor of cell death by a yet unknown mechanism. In order to clarify its molecular mechanism of action, we used the yeast two-hybrid system to screen for proteins th...

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Veröffentlicht in:	Oncogene 1999-07, Vol.18 (29), p.4182-4190
Hauptverfasser:	DE VALCK, D, JIN, D.-Y, HEYNINCK, K, VAN DE CRAEN, M, CONTRERAS, R, FIERS, W, JEANG, K.-T, BEYAERT, R
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Ageing, cell death AIDS/HIV Amino Acid Chloromethyl Ketones - pharmacology Amino Acid Sequence Animals APO-1 protein Apoptosis Apoptosis - drug effects Base Sequence Biological and medical sciences Carrier Proteins - isolation & purification Carrier Proteins - metabolism Caspase inhibitors Caspase-3 Caspase-6 Caspase-7 Caspases - metabolism CD95 antigen Cell death Cell Line Cell physiology Cloning, Molecular Cowpox Cysteine Endopeptidases Cysteine Proteinase Inhibitors - pharmacology Dactinomycin - pharmacology DNA, Complementary - genetics DNA-Binding Proteins Fas antigen fas Receptor - physiology Fundamental and applied biological sciences. Psychology Genes HeLa Cells Humans Inflammation Intracellular Signaling Peptides and Proteins Lymphocytes T Mice Molecular and cellular biology Molecular Sequence Data mRNA Neoplasm Proteins Nuclear Proteins Nucleic Acid Synthesis Inhibitors - pharmacology Oligonucleotides, Antisense - pharmacology Protein Binding Protein Processing, Post-Translational Proteins Proteins - metabolism Proteolysis Recombinant Fusion Proteins - metabolism RNA, Messenger - genetics Saccharomyces cerevisiae - genetics Serpins - physiology Substrate Specificity Transfection Tumor necrosis factor Tumor Necrosis Factor alpha-Induced Protein 3 Tumor Necrosis Factor-alpha - pharmacology Tumor necrosis factor-TNF Tumors Viral Proteins Zinc finger proteins Zinc Fingers
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