Attenuation of ischemia induced increases in sodium and calcium by the aldose reductase inhibitor Zopolrestat

We have previously demonstrated that zopolrestat, an inhibitor of the enzyme aldose reductase, reduces ischemic injury in hearts from diabetic and non-diabetic rats. To further explore potential cardioprotective mechanisms of zopolrestat, we measured changes in intracellular sodium, calcium, and Na+...

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Veröffentlicht in:	Cardiovascular research 1999-04, Vol.42 (1), p.130-139
Hauptverfasser:	RAMASAMY, R, HONG LIU, OATES, P. J, SCHAEFER, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Reductase - antagonists & inhibitors Analysis of Variance Animals Benzothiazoles Biological and medical sciences Calcium - analysis Calcium - metabolism Cardiology. Vascular system Coronary heart disease Diabetes Mellitus, Type 2 - metabolism Enzyme Inhibitors - metabolism Enzyme Inhibitors - therapeutic use Heart Intracellular Fluid - chemistry Intracellular Fluid - metabolism Magnetic Resonance Spectroscopy Medical sciences Metals - analysis Metals - metabolism Myocardial Ischemia - drug therapy Myocardial Ischemia - metabolism Myocardial Reperfusion Myocardium - metabolism Perfusion Phthalazines - therapeutic use Rats Rats, Inbred BB Sodium - analysis Sodium - metabolism Sodium-Potassium-Exchanging ATPase - metabolism Thiazoles - therapeutic use Time Factors
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