Circulating and imaging markers for angiogenesis
Abundant preclinical and indirect clinical data have for several decades convincingly supported the notion that anti-angiogenesis is an effective strategy for the inhibition of tumor growth. The recent success achieved in patients with metastatic colon carcinoma using a neutralizing antibody directe...
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| Veröffentlicht in: | Angiogenesis (London) 2008-12, Vol.11 (4), p.321-335 |
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| creator | Pathak, Arvind P. Hochfeld, Warren E. Goodman, Simon L. Pepper, Michael S. |
| description | Abundant preclinical and indirect clinical data have for several decades convincingly supported the notion that anti-angiogenesis is an effective strategy for the inhibition of tumor growth. The recent success achieved in patients with metastatic colon carcinoma using a neutralizing antibody directed against vascular endothelial growth factor (VEGF) has translated preclinical optimism into a clinical reality.With this transformation in the field of angiogenesis has come a need for reliable surrogate markers. A surrogate marker by definition serves as a substitute for the underlying process in question, and in the case of angiogenesis, microvessel density (usually in so-called “hot-spots”) has until now been the most widely used parameter. However, this parameter is more akin to a static “snap-shot” and does not lend itself either to the dynamic in situ assessment of the status of the tumor microvasculature or to the molecular factors that regulate its growth and involution. This has led to an acute need for developing circulating and imaging markers of angiogenesis that can be monitored in vivo at repeated intervals in large number of patients with a variety of tumors in a non-invasive manner. Such markers of angiogenesis are the subject of this review. |
| doi_str_mv | 10.1007/s10456-008-9119-z |
| format | Article |
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This has led to an acute need for developing circulating and imaging markers of angiogenesis that can be monitored in vivo at repeated intervals in large number of patients with a variety of tumors in a non-invasive manner. Such markers of angiogenesis are the subject of this review.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - blood</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood and lymphatic vessels</subject><subject>Cancer Research</subject><subject>Cardiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular system</subject><subject>Cell Biology</subject><subject>Diagnostic Imaging</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>Neovascularization, Pathologic - blood</subject><subject>Neovascularization, Pathologic - diagnosis</subject><subject>Oncology</subject><subject>Ophthalmology</subject><subject>Radionuclide investigations</subject><subject>Review Paper</subject><issn>0969-6970</issn><issn>1573-7209</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kM9LwzAUx4Mobk7_AC8yBL1F30vSNjnK8BcMvOg5pG1SOrt2JuvB_fVmtDgQPCW8fN5733wIuUS4Q4DsPiCIJKUAkipERXdHZIpJxmnGQB2TKahU0VRlMCFnIawAYkGKUzJBqVgimJgSWNS-6BuzrdtqbtpyXq9Ntb-vjf-0Psxd52O9qrvKtjbU4ZycONMEezGeM_Lx9Pi-eKHLt-fXxcOSFkKwLZWmTHKRQ6K4VKbAQgluy0Qi5JwpJyF1ucgEcxxtKViS8qyUrlQxo0slMD4jt8Pcje--ehu2el2HwjaNaW3XB50qxbOUqwhe_wFXXe_bmE0zRJGhkjJCOECF70Lw1umNjz_13xpB713qwaWOLvXepd7FnqtxcJ-vbXnoGOVF4GYETChM47xpizr8cgwBJWM8cmzgQnxqK-sPCf_f_gOY0Yox</recordid><startdate>20081201</startdate><enddate>20081201</enddate><creator>Pathak, Arvind P.</creator><creator>Hochfeld, Warren E.</creator><creator>Goodman, Simon L.</creator><creator>Pepper, Michael S.</creator><general>Springer Netherlands</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20081201</creationdate><title>Circulating and imaging markers for angiogenesis</title><author>Pathak, Arvind P. ; Hochfeld, Warren E. ; Goodman, Simon L. ; Pepper, Michael S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-8ad5b4b059389ac1c943ed5810b329f806fb4742f31ed425637d8fd9000f68023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - blood</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood and lymphatic vessels</topic><topic>Cancer Research</topic><topic>Cardiology</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular system</topic><topic>Cell Biology</topic><topic>Diagnostic Imaging</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>Neovascularization, Pathologic - blood</topic><topic>Neovascularization, Pathologic - diagnosis</topic><topic>Oncology</topic><topic>Ophthalmology</topic><topic>Radionuclide investigations</topic><topic>Review Paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pathak, Arvind P.</creatorcontrib><creatorcontrib>Hochfeld, Warren E.</creatorcontrib><creatorcontrib>Goodman, Simon L.</creatorcontrib><creatorcontrib>Pepper, Michael S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Angiogenesis (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pathak, Arvind P.</au><au>Hochfeld, Warren E.</au><au>Goodman, Simon L.</au><au>Pepper, Michael S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating and imaging markers for angiogenesis</atitle><jtitle>Angiogenesis (London)</jtitle><stitle>Angiogenesis</stitle><addtitle>Angiogenesis</addtitle><date>2008-12-01</date><risdate>2008</risdate><volume>11</volume><issue>4</issue><spage>321</spage><epage>335</epage><pages>321-335</pages><issn>0969-6970</issn><eissn>1573-7209</eissn><coden>AGIOFT</coden><abstract>Abundant preclinical and indirect clinical data have for several decades convincingly supported the notion that anti-angiogenesis is an effective strategy for the inhibition of tumor growth. 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| subjects | Animals Biological and medical sciences Biomarkers, Tumor - blood Biomedical and Life Sciences Biomedicine Blood and lymphatic vessels Cancer Research Cardiology Cardiology. Vascular system Cardiovascular system Cell Biology Diagnostic Imaging Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Humans Investigative techniques, diagnostic techniques (general aspects) Medical sciences Neovascularization, Pathologic - blood Neovascularization, Pathologic - diagnosis Oncology Ophthalmology Radionuclide investigations Review Paper |
| title | Circulating and imaging markers for angiogenesis |
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