Changing Epidemiology of Group B Streptococcal Colonization
To define factors influencing vertical transmission of and neonatal colonization with group B streptococci (GBS) in neonates representing ethnically and economically diverse populations, and to determine the serotype distribution of isolates, especially new types IV-VIII. Prospective, cross-sectiona...
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| Veröffentlicht in: | Pediatrics (Evanston) 1999-08, Vol.104 (2), p.203-209 |
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| creator | Hickman, Melissa E Rench, Marcia A Ferrieri, Patricia Baker, Carol J |
| description | To define factors influencing vertical transmission of and neonatal colonization with group B streptococci (GBS) in neonates representing ethnically and economically diverse populations, and to determine the serotype distribution of isolates, especially new types IV-VIII.
Prospective, cross-sectional study of neonates born to women evaluated for GBS colonization at admission for delivery to one of four hospitals between January 1994 and February 1995. Cultures of throat, umbilicus, and rectum were obtained from 24- to 48-hour-old infants for isolation of GBS. Isolates were classified by capsular polysaccharide (I-VIII) and C protein (alpha and beta) antigen components.
Colonization was detected in 28% of 546 mothers, was higher in blacks than whites (40.6% vs 20.3%) and Hispanics (26. 9%), and was not influenced by socioeconomic status. Overall, ethnic origin did not seem to be related to GBS serotype, but whites were more likely to carry the new type V strain than blacks (6 out of 24 [25%] vs 1 out of 43 [2%]). Vertical transmission of GBS to neonates was significantly diminished when their mothers had intrapartum antibiotics (0% vs 52%), rupture of membranes |
| doi_str_mv | 10.1542/peds.104.2.203 |
| format | Article |
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Prospective, cross-sectional study of neonates born to women evaluated for GBS colonization at admission for delivery to one of four hospitals between January 1994 and February 1995. Cultures of throat, umbilicus, and rectum were obtained from 24- to 48-hour-old infants for isolation of GBS. Isolates were classified by capsular polysaccharide (I-VIII) and C protein (alpha and beta) antigen components.
Colonization was detected in 28% of 546 mothers, was higher in blacks than whites (40.6% vs 20.3%) and Hispanics (26. 9%), and was not influenced by socioeconomic status. Overall, ethnic origin did not seem to be related to GBS serotype, but whites were more likely to carry the new type V strain than blacks (6 out of 24 [25%] vs 1 out of 43 [2%]). Vertical transmission of GBS to neonates was significantly diminished when their mothers had intrapartum antibiotics (0% vs 52%), rupture of membranes <12 hours before delivery (38.4% vs 73.3%), or delivery by cesarean section (25.9% vs 45.2%). Colonization with GBS was found in 13.8% of 549 neonates, was acquired vertically in 97%, and was less frequent in neonates at the private hospitals (4% vs 20%) where intrapartum antibiotics were given more frequently (34.7% vs 17.3%). Among isolates from neonates, serotype Ia predominated (31.6%) followed by types II (25%), III (22.4%), and V (11.8%); approximately 40% of strains contained C protein antigen.
Changes in the epidemiology of GBS colonization included diminished rates in some populations associated with use of maternal intrapartum antibiotics, and a shift in serotype prevalence, with Ia as predominant and V, in addition to II and III, as common.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.104.2.203</identifier><identifier>PMID: 10428995</identifier><identifier>CODEN: PEDIAU</identifier><language>eng</language><publisher>Elk Grove Village, IL: Am Acad Pediatrics</publisher><subject>Antibiotic Prophylaxis ; Bacterial diseases ; Biological and medical sciences ; Cross-Sectional Studies ; Disease transmission ; Female ; Human bacterial diseases ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical ; Infectious diseases ; Maternal-fetal exchange ; Medical sciences ; Minnesota - epidemiology ; Pregnancy ; Pregnancy Complications, Infectious ; Prevention ; Prospective Studies ; Serotyping ; Staphylococcal infections, streptococcal infections, pneumococcal infections ; Streptococcal infections ; Streptococcal Infections - epidemiology ; Streptococcal Infections - prevention & control ; Streptococcal Infections - transmission ; Streptococcus agalactiae ; Streptococcus agalactiae - classification ; Streptococcus agalactiae - isolation & purification</subject><ispartof>Pediatrics (Evanston), 1999-08, Vol.104 (2), p.203-209</ispartof><rights>1999 INIST-CNRS</rights><rights>COPYRIGHT 1999 American Academy of Pediatrics</rights><rights>COPYRIGHT 1999 American Academy of Pediatrics</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c570t-eb666618e8dd1714344567c32a434235da5b312c788ec20d876516b8cb6f67d63</citedby><cites>FETCH-LOGICAL-c570t-eb666618e8dd1714344567c32a434235da5b312c788ec20d876516b8cb6f67d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1924021$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10428995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hickman, Melissa E</creatorcontrib><creatorcontrib>Rench, Marcia A</creatorcontrib><creatorcontrib>Ferrieri, Patricia</creatorcontrib><creatorcontrib>Baker, Carol J</creatorcontrib><title>Changing Epidemiology of Group B Streptococcal Colonization</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>To define factors influencing vertical transmission of and neonatal colonization with group B streptococci (GBS) in neonates representing ethnically and economically diverse populations, and to determine the serotype distribution of isolates, especially new types IV-VIII.
Prospective, cross-sectional study of neonates born to women evaluated for GBS colonization at admission for delivery to one of four hospitals between January 1994 and February 1995. Cultures of throat, umbilicus, and rectum were obtained from 24- to 48-hour-old infants for isolation of GBS. Isolates were classified by capsular polysaccharide (I-VIII) and C protein (alpha and beta) antigen components.
Colonization was detected in 28% of 546 mothers, was higher in blacks than whites (40.6% vs 20.3%) and Hispanics (26. 9%), and was not influenced by socioeconomic status. Overall, ethnic origin did not seem to be related to GBS serotype, but whites were more likely to carry the new type V strain than blacks (6 out of 24 [25%] vs 1 out of 43 [2%]). Vertical transmission of GBS to neonates was significantly diminished when their mothers had intrapartum antibiotics (0% vs 52%), rupture of membranes <12 hours before delivery (38.4% vs 73.3%), or delivery by cesarean section (25.9% vs 45.2%). Colonization with GBS was found in 13.8% of 549 neonates, was acquired vertically in 97%, and was less frequent in neonates at the private hospitals (4% vs 20%) where intrapartum antibiotics were given more frequently (34.7% vs 17.3%). Among isolates from neonates, serotype Ia predominated (31.6%) followed by types II (25%), III (22.4%), and V (11.8%); approximately 40% of strains contained C protein antigen.
Changes in the epidemiology of GBS colonization included diminished rates in some populations associated with use of maternal intrapartum antibiotics, and a shift in serotype prevalence, with Ia as predominant and V, in addition to II and III, as common.</description><subject>Antibiotic Prophylaxis</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Cross-Sectional Studies</subject><subject>Disease transmission</subject><subject>Female</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infectious Disease Transmission, Vertical</subject><subject>Infectious diseases</subject><subject>Maternal-fetal exchange</subject><subject>Medical sciences</subject><subject>Minnesota - epidemiology</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious</subject><subject>Prevention</subject><subject>Prospective Studies</subject><subject>Serotyping</subject><subject>Staphylococcal infections, streptococcal infections, pneumococcal infections</subject><subject>Streptococcal infections</subject><subject>Streptococcal Infections - epidemiology</subject><subject>Streptococcal Infections - prevention & control</subject><subject>Streptococcal Infections - transmission</subject><subject>Streptococcus agalactiae</subject><subject>Streptococcus agalactiae - classification</subject><subject>Streptococcus agalactiae - isolation & purification</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkcGP1CAUxonRuOPq1aPpwRgP2woUCs2e1mYdTSbZg3omlL52MJ1SgUbXv14mM8nsJAMHHvB7fOT7EHpLcEE4o59m6EJBMCtoQXH5DK0IrmXOqODP0QrjkuQMY36FXoXwC2PMuKAv0VVqoLKu-QrdNls9DXYasvvZdrCzbnTDY-b6bO3dMmefs-_RwxydccboMWvS_WT_6Wjd9Bq96PUY4M1xvUY_v9z_aL7mm4f1t-ZukxsucMyhrdIgEmTXEUFYyRivhCmpTiUtead5WxJqhJRgKO6kqDipWmnaqq9EV5XX6MPh3dm73wuEqHY2GBhHPYFbgqrquqwYEwm8OYCDHkHZqXfRazPABF6nb0Nv0_EdTx7gmsqE5xfwNPc-mEv8xzM-IRH-xkEvISi53pyhN5dQ48YRBlDJnubhDC8OuPEuBA-9mr3daf-oCFb7nNU-57RhiqqUc2p4d7RkaXfQPcEPwSbg_RHQIeXWez0ZG05cTRmm5CS8tcP2j_WwF7I6emvCk_Ik_B_hzL0Z</recordid><startdate>19990801</startdate><enddate>19990801</enddate><creator>Hickman, Melissa E</creator><creator>Rench, Marcia A</creator><creator>Ferrieri, Patricia</creator><creator>Baker, Carol J</creator><general>Am Acad Pediatrics</general><general>American Academy of Pediatrics</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>7X8</scope></search><sort><creationdate>19990801</creationdate><title>Changing Epidemiology of Group B Streptococcal Colonization</title><author>Hickman, Melissa E ; Rench, Marcia A ; Ferrieri, Patricia ; Baker, Carol J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c570t-eb666618e8dd1714344567c32a434235da5b312c788ec20d876516b8cb6f67d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Antibiotic Prophylaxis</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Cross-Sectional Studies</topic><topic>Disease transmission</topic><topic>Female</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infectious Disease Transmission, Vertical</topic><topic>Infectious diseases</topic><topic>Maternal-fetal exchange</topic><topic>Medical sciences</topic><topic>Minnesota - epidemiology</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious</topic><topic>Prevention</topic><topic>Prospective Studies</topic><topic>Serotyping</topic><topic>Staphylococcal infections, streptococcal infections, pneumococcal infections</topic><topic>Streptococcal infections</topic><topic>Streptococcal Infections - epidemiology</topic><topic>Streptococcal Infections - prevention & control</topic><topic>Streptococcal Infections - transmission</topic><topic>Streptococcus agalactiae</topic><topic>Streptococcus agalactiae - classification</topic><topic>Streptococcus agalactiae - isolation & purification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hickman, Melissa E</creatorcontrib><creatorcontrib>Rench, Marcia A</creatorcontrib><creatorcontrib>Ferrieri, Patricia</creatorcontrib><creatorcontrib>Baker, Carol J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hickman, Melissa E</au><au>Rench, Marcia A</au><au>Ferrieri, Patricia</au><au>Baker, Carol J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changing Epidemiology of Group B Streptococcal Colonization</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>1999-08-01</date><risdate>1999</risdate><volume>104</volume><issue>2</issue><spage>203</spage><epage>209</epage><pages>203-209</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><coden>PEDIAU</coden><abstract>To define factors influencing vertical transmission of and neonatal colonization with group B streptococci (GBS) in neonates representing ethnically and economically diverse populations, and to determine the serotype distribution of isolates, especially new types IV-VIII.
Prospective, cross-sectional study of neonates born to women evaluated for GBS colonization at admission for delivery to one of four hospitals between January 1994 and February 1995. Cultures of throat, umbilicus, and rectum were obtained from 24- to 48-hour-old infants for isolation of GBS. Isolates were classified by capsular polysaccharide (I-VIII) and C protein (alpha and beta) antigen components.
Colonization was detected in 28% of 546 mothers, was higher in blacks than whites (40.6% vs 20.3%) and Hispanics (26. 9%), and was not influenced by socioeconomic status. Overall, ethnic origin did not seem to be related to GBS serotype, but whites were more likely to carry the new type V strain than blacks (6 out of 24 [25%] vs 1 out of 43 [2%]). Vertical transmission of GBS to neonates was significantly diminished when their mothers had intrapartum antibiotics (0% vs 52%), rupture of membranes <12 hours before delivery (38.4% vs 73.3%), or delivery by cesarean section (25.9% vs 45.2%). Colonization with GBS was found in 13.8% of 549 neonates, was acquired vertically in 97%, and was less frequent in neonates at the private hospitals (4% vs 20%) where intrapartum antibiotics were given more frequently (34.7% vs 17.3%). Among isolates from neonates, serotype Ia predominated (31.6%) followed by types II (25%), III (22.4%), and V (11.8%); approximately 40% of strains contained C protein antigen.
Changes in the epidemiology of GBS colonization included diminished rates in some populations associated with use of maternal intrapartum antibiotics, and a shift in serotype prevalence, with Ia as predominant and V, in addition to II and III, as common.</abstract><cop>Elk Grove Village, IL</cop><pub>Am Acad Pediatrics</pub><pmid>10428995</pmid><doi>10.1542/peds.104.2.203</doi><tpages>7</tpages></addata></record> |
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| ispartof | Pediatrics (Evanston), 1999-08, Vol.104 (2), p.203-209 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Antibiotic Prophylaxis Bacterial diseases Biological and medical sciences Cross-Sectional Studies Disease transmission Female Human bacterial diseases Humans Infant, Newborn Infectious Disease Transmission, Vertical Infectious diseases Maternal-fetal exchange Medical sciences Minnesota - epidemiology Pregnancy Pregnancy Complications, Infectious Prevention Prospective Studies Serotyping Staphylococcal infections, streptococcal infections, pneumococcal infections Streptococcal infections Streptococcal Infections - epidemiology Streptococcal Infections - prevention & control Streptococcal Infections - transmission Streptococcus agalactiae Streptococcus agalactiae - classification Streptococcus agalactiae - isolation & purification |
| title | Changing Epidemiology of Group B Streptococcal Colonization |
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