Perceptual and response interference in children with attention-deficit hyperactivity disorder, and the effects of methylphenidate
Fourteen children with attention-deficit hyperactivity disorder (ADHD) and 14 normal control children were compared with respect to stimulus- and response-related processes. Subjects with ADHD took part in two additional sessions under methylphenidate or placebo. In both experiments, performance and...
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| Veröffentlicht in: | Psychophysiology 1999-07, Vol.36 (4), p.419-429 |
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| creator | JONKMAN, L.M. KEMNER, C. VERBATEN, M.N. VAN ENGELAND, H. KENEMANS, J.L. CAMFFERMAN, G. BUITELAAR, J.K. KOELEGA, H.S. |
| description | Fourteen children with attention-deficit hyperactivity
disorder (ADHD) and 14 normal control children were compared
with respect to stimulus- and response-related processes.
Subjects with ADHD took part in two additional sessions
under methylphenidate or placebo. In both experiments,
performance and electrophysiological measures such as the
P2, N2, and P3 components of event-related potential and
electromyogram (EMG) activity were measured during an Eriksen
flanker task. In both groups of children, reaction times
(RTs) to arrow stimuli incongruent with the target were
longer than those to neutral stimuli (response interference),
which were again slower than RTs to target-alone stimuli
(perceptual interference). Children with ADHD made more
errors to incongruent stimuli and showed more response
interference. For correct responses, no differences between
the groups in response interference effects on reaction
time, P2, N2, and P3 latency, or EMG onset were found.
Methylphenidate had a general enhancing effect on accuracy
but did not specifically reduce interference from the flanking
stimuli. Methylphenidate had no effects on RT, N2 and P2
latency, P3 amplitude or latency, or EMG activity. The
conclusion that methylphenidate did not influence response
processes contrasts sharply with findings reported by authors
using the Sternberg memory search task. |
| doi_str_mv | 10.1111/1469-8986.3640419 |
| format | Article |
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disorder (ADHD) and 14 normal control children were compared
with respect to stimulus- and response-related processes.
Subjects with ADHD took part in two additional sessions
under methylphenidate or placebo. In both experiments,
performance and electrophysiological measures such as the
P2, N2, and P3 components of event-related potential and
electromyogram (EMG) activity were measured during an Eriksen
flanker task. In both groups of children, reaction times
(RTs) to arrow stimuli incongruent with the target were
longer than those to neutral stimuli (response interference),
which were again slower than RTs to target-alone stimuli
(perceptual interference). Children with ADHD made more
errors to incongruent stimuli and showed more response
interference. For correct responses, no differences between
the groups in response interference effects on reaction
time, P2, N2, and P3 latency, or EMG onset were found.
Methylphenidate had a general enhancing effect on accuracy
but did not specifically reduce interference from the flanking
stimuli. Methylphenidate had no effects on RT, N2 and P2
latency, P3 amplitude or latency, or EMG activity. The
conclusion that methylphenidate did not influence response
processes contrasts sharply with findings reported by authors
using the Sternberg memory search task.</description><identifier>ISSN: 0048-5772</identifier><identifier>EISSN: 1469-8986</identifier><identifier>EISSN: 1540-5958</identifier><identifier>DOI: 10.1111/1469-8986.3640419</identifier><identifier>PMID: 10432791</identifier><identifier>CODEN: PSPHAF</identifier><language>eng</language><publisher>Oxford, UK: Cambridge University Press</publisher><subject>Adolescent ; Attention - drug effects ; Attention - physiology ; Attention Deficit Disorder with Hyperactivity - drug therapy ; Attention Deficit Disorder with Hyperactivity - physiopathology ; Attention-deficit hyperactivity disorder ; Biological and medical sciences ; Case-Control Studies ; Central Nervous System Stimulants - pharmacology ; Cerebral Cortex - drug effects ; Cerebral Cortex - physiopathology ; Child ; Double-Blind Method ; Event-related potentials ; Evoked Potentials - drug effects ; Evoked Potentials - physiology ; Female ; Flanker task ; Humans ; Male ; Medical sciences ; Methylphenidate ; Methylphenidate - pharmacology ; Multivariate Analysis ; Neural Inhibition - drug effects ; Neural Inhibition - physiology ; Neuropharmacology ; Perceptual Masking - physiology ; Perceptual processes ; Pharmacology. Drug treatments ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychomotor Performance - drug effects ; Psychomotor Performance - physiology ; Psychopharmacology ; Reaction Time - drug effects ; Reaction Time - physiology ; Response processes ; Volition - drug effects ; Volition - physiology</subject><ispartof>Psychophysiology, 1999-07, Vol.36 (4), p.419-429</ispartof><rights>1999 Society for Psychophysiological Research</rights><rights>Copyright © 2003 Society for Psychophysiological Research</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3969-f943104ec13499ac731a4b87eddd9adfbe938f33299b24c82b442757914309603</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1469-8986.3640419$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1469-8986.3640419$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1870648$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10432791$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>JONKMAN, L.M.</creatorcontrib><creatorcontrib>KEMNER, C.</creatorcontrib><creatorcontrib>VERBATEN, M.N.</creatorcontrib><creatorcontrib>VAN ENGELAND, H.</creatorcontrib><creatorcontrib>KENEMANS, J.L.</creatorcontrib><creatorcontrib>CAMFFERMAN, G.</creatorcontrib><creatorcontrib>BUITELAAR, J.K.</creatorcontrib><creatorcontrib>KOELEGA, H.S.</creatorcontrib><title>Perceptual and response interference in children with attention-deficit hyperactivity disorder, and the effects of methylphenidate</title><title>Psychophysiology</title><addtitle>Psychophysiology</addtitle><description>Fourteen children with attention-deficit hyperactivity
disorder (ADHD) and 14 normal control children were compared
with respect to stimulus- and response-related processes.
Subjects with ADHD took part in two additional sessions
under methylphenidate or placebo. In both experiments,
performance and electrophysiological measures such as the
P2, N2, and P3 components of event-related potential and
electromyogram (EMG) activity were measured during an Eriksen
flanker task. In both groups of children, reaction times
(RTs) to arrow stimuli incongruent with the target were
longer than those to neutral stimuli (response interference),
which were again slower than RTs to target-alone stimuli
(perceptual interference). Children with ADHD made more
errors to incongruent stimuli and showed more response
interference. For correct responses, no differences between
the groups in response interference effects on reaction
time, P2, N2, and P3 latency, or EMG onset were found.
Methylphenidate had a general enhancing effect on accuracy
but did not specifically reduce interference from the flanking
stimuli. Methylphenidate had no effects on RT, N2 and P2
latency, P3 amplitude or latency, or EMG activity. The
conclusion that methylphenidate did not influence response
processes contrasts sharply with findings reported by authors
using the Sternberg memory search task.</description><subject>Adolescent</subject><subject>Attention - drug effects</subject><subject>Attention - physiology</subject><subject>Attention Deficit Disorder with Hyperactivity - drug therapy</subject><subject>Attention Deficit Disorder with Hyperactivity - physiopathology</subject><subject>Attention-deficit hyperactivity disorder</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Central Nervous System Stimulants - pharmacology</subject><subject>Cerebral Cortex - drug effects</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Child</subject><subject>Double-Blind Method</subject><subject>Event-related potentials</subject><subject>Evoked Potentials - drug effects</subject><subject>Evoked Potentials - physiology</subject><subject>Female</subject><subject>Flanker task</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methylphenidate</subject><subject>Methylphenidate - pharmacology</subject><subject>Multivariate Analysis</subject><subject>Neural Inhibition - drug effects</subject><subject>Neural Inhibition - physiology</subject><subject>Neuropharmacology</subject><subject>Perceptual Masking - physiology</subject><subject>Perceptual processes</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychomotor Performance - drug effects</subject><subject>Psychomotor Performance - physiology</subject><subject>Psychopharmacology</subject><subject>Reaction Time - drug effects</subject><subject>Reaction Time - physiology</subject><subject>Response processes</subject><subject>Volition - drug effects</subject><subject>Volition - physiology</subject><issn>0048-5772</issn><issn>1469-8986</issn><issn>1540-5958</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuP1iAUhhujcb4Z_QFuDAvjajpCoRdWxnxxRuNEv8RbdEMoHCxjbwJ17NZfLrXN6EpJCDnkOS_nfUmSBwSfkbieEFbwtOJVcUYLhhnht5Ldzd3tZIcxq9K8LLOj5Nj7K4wxJ1l2NzkimNGs5GSX_DyAUzCGSbZI9ho58OPQe0C2D-AMOOjVUiDV2FbHCl3b0CAZAvTBDn2qwVhlA2rmEZxUwX63YUba-sFpcKe_RUMDCIwBFTwaDOogNHM7NtBbLQPcS-4Y2Xq4v50nyfvz5-_2L9LLNxcv988uU0V59GQ4o3FuUIQyzqUqKZGsrkrQWnOpTQ2cVobSjPM6Y6rKasayMo8uGcW8wPQkebzqjm74NoEPorNeQdvKHobJi4JzmseOCJIVVG7w3oERo7OddLMgWCzBiyVksYQstuBjz8NNfKo70H91rElH4NEGSK9ka5zslfV_uKrEBasi9nTFrm0L8_8fFoe3nw7LjrXYJklXBesD_LhRkO6rKEpa5uLj6wuBX-2rD3lxLj5Hnm5uZVc7q7-AuBom18ev-IffX6arvfo</recordid><startdate>199907</startdate><enddate>199907</enddate><creator>JONKMAN, L.M.</creator><creator>KEMNER, C.</creator><creator>VERBATEN, M.N.</creator><creator>VAN ENGELAND, H.</creator><creator>KENEMANS, J.L.</creator><creator>CAMFFERMAN, G.</creator><creator>BUITELAAR, J.K.</creator><creator>KOELEGA, H.S.</creator><general>Cambridge University Press</general><general>Blackwell Publishing</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199907</creationdate><title>Perceptual and response interference in children with attention-deficit hyperactivity disorder, and the effects of methylphenidate</title><author>JONKMAN, L.M. ; KEMNER, C. ; VERBATEN, M.N. ; VAN ENGELAND, H. ; KENEMANS, J.L. ; CAMFFERMAN, G. ; BUITELAAR, J.K. ; KOELEGA, H.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3969-f943104ec13499ac731a4b87eddd9adfbe938f33299b24c82b442757914309603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adolescent</topic><topic>Attention - drug effects</topic><topic>Attention - physiology</topic><topic>Attention Deficit Disorder with Hyperactivity - drug therapy</topic><topic>Attention Deficit Disorder with Hyperactivity - physiopathology</topic><topic>Attention-deficit hyperactivity disorder</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Central Nervous System Stimulants - pharmacology</topic><topic>Cerebral Cortex - drug effects</topic><topic>Cerebral Cortex - physiopathology</topic><topic>Child</topic><topic>Double-Blind Method</topic><topic>Event-related potentials</topic><topic>Evoked Potentials - drug effects</topic><topic>Evoked Potentials - physiology</topic><topic>Female</topic><topic>Flanker task</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methylphenidate</topic><topic>Methylphenidate - pharmacology</topic><topic>Multivariate Analysis</topic><topic>Neural Inhibition - drug effects</topic><topic>Neural Inhibition - physiology</topic><topic>Neuropharmacology</topic><topic>Perceptual Masking - physiology</topic><topic>Perceptual processes</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychomotor Performance - drug effects</topic><topic>Psychomotor Performance - physiology</topic><topic>Psychopharmacology</topic><topic>Reaction Time - drug effects</topic><topic>Reaction Time - physiology</topic><topic>Response processes</topic><topic>Volition - drug effects</topic><topic>Volition - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JONKMAN, L.M.</creatorcontrib><creatorcontrib>KEMNER, C.</creatorcontrib><creatorcontrib>VERBATEN, M.N.</creatorcontrib><creatorcontrib>VAN ENGELAND, H.</creatorcontrib><creatorcontrib>KENEMANS, J.L.</creatorcontrib><creatorcontrib>CAMFFERMAN, G.</creatorcontrib><creatorcontrib>BUITELAAR, J.K.</creatorcontrib><creatorcontrib>KOELEGA, H.S.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JONKMAN, L.M.</au><au>KEMNER, C.</au><au>VERBATEN, M.N.</au><au>VAN ENGELAND, H.</au><au>KENEMANS, J.L.</au><au>CAMFFERMAN, G.</au><au>BUITELAAR, J.K.</au><au>KOELEGA, H.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perceptual and response interference in children with attention-deficit hyperactivity disorder, and the effects of methylphenidate</atitle><jtitle>Psychophysiology</jtitle><addtitle>Psychophysiology</addtitle><date>1999-07</date><risdate>1999</risdate><volume>36</volume><issue>4</issue><spage>419</spage><epage>429</epage><pages>419-429</pages><issn>0048-5772</issn><eissn>1469-8986</eissn><eissn>1540-5958</eissn><coden>PSPHAF</coden><abstract>Fourteen children with attention-deficit hyperactivity
disorder (ADHD) and 14 normal control children were compared
with respect to stimulus- and response-related processes.
Subjects with ADHD took part in two additional sessions
under methylphenidate or placebo. In both experiments,
performance and electrophysiological measures such as the
P2, N2, and P3 components of event-related potential and
electromyogram (EMG) activity were measured during an Eriksen
flanker task. In both groups of children, reaction times
(RTs) to arrow stimuli incongruent with the target were
longer than those to neutral stimuli (response interference),
which were again slower than RTs to target-alone stimuli
(perceptual interference). Children with ADHD made more
errors to incongruent stimuli and showed more response
interference. For correct responses, no differences between
the groups in response interference effects on reaction
time, P2, N2, and P3 latency, or EMG onset were found.
Methylphenidate had a general enhancing effect on accuracy
but did not specifically reduce interference from the flanking
stimuli. Methylphenidate had no effects on RT, N2 and P2
latency, P3 amplitude or latency, or EMG activity. The
conclusion that methylphenidate did not influence response
processes contrasts sharply with findings reported by authors
using the Sternberg memory search task.</abstract><cop>Oxford, UK</cop><pub>Cambridge University Press</pub><pmid>10432791</pmid><doi>10.1111/1469-8986.3640419</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0048-5772 |
| ispartof | Psychophysiology, 1999-07, Vol.36 (4), p.419-429 |
| issn | 0048-5772 1469-8986 1540-5958 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69935275 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Attention - drug effects Attention - physiology Attention Deficit Disorder with Hyperactivity - drug therapy Attention Deficit Disorder with Hyperactivity - physiopathology Attention-deficit hyperactivity disorder Biological and medical sciences Case-Control Studies Central Nervous System Stimulants - pharmacology Cerebral Cortex - drug effects Cerebral Cortex - physiopathology Child Double-Blind Method Event-related potentials Evoked Potentials - drug effects Evoked Potentials - physiology Female Flanker task Humans Male Medical sciences Methylphenidate Methylphenidate - pharmacology Multivariate Analysis Neural Inhibition - drug effects Neural Inhibition - physiology Neuropharmacology Perceptual Masking - physiology Perceptual processes Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychomotor Performance - drug effects Psychomotor Performance - physiology Psychopharmacology Reaction Time - drug effects Reaction Time - physiology Response processes Volition - drug effects Volition - physiology |
| title | Perceptual and response interference in children with attention-deficit hyperactivity disorder, and the effects of methylphenidate |
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