Staphylococcus aureus SigB activity promotes a strong fibronectin-bacterium interaction which may sustain host tissue colonization by small-colony variants isolated from cystic fibrosis patients

Genes encoding cell-surface proteins regulated by SigB are stably expressed in Staphylococcus aureus small-colony variants (SCVs) isolated from cystic fibrosis (CF) patients. Our hypothesis is that CF-isolated SCVs are locked into a colonization state by sustaining the expression of adhesins such as...

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Veröffentlicht in:	Molecular microbiology 2008-12, Vol.70 (6), p.1540-1555
Hauptverfasser:	Mitchell, Gabriel, Lamontagne, Charles-Antoine, Brouillette, Eric, Grondin, Gilles, Talbot, Brian G, Grandbois, Michel, Malouin, François
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesins, Bacterial - metabolism Bacterial Adhesion Bacterial proteins Bacterial Proteins - metabolism Bacteriology Biological and medical sciences Cell adhesion & migration Cystic fibrosis Cystic Fibrosis - metabolism Cystic Fibrosis - microbiology Fibronectins - metabolism Fundamental and applied biological sciences. Psychology Gene expression Host-Pathogen Interactions Humans Microbiology Miscellaneous Mutation Sigma Factor - metabolism Staphylococcus aureus Staphylococcus infections
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