Targeted Disruption of CRE-Binding Factor TREB5 Gene Leads to Cellular Necrosis in Cardiac Myocytes at the Embryonic Stage

TREB5 (hXBP-1) is a basic region leucine zipper protein which binds to a CRE-like element in both human T-cell leukemia virus type 1 and MHC class II genes. To study the function(s) of TREB5 in normal development, we have generated TREB5 deficient mice by gene targeting. Heterozygous mutant mice hav...

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