The effect of intracellular iron concentration and nitrogen monoxide on Nramp2 expression and non‐transferrin‐bound iron uptake

Recent studies have demonstrated that the protein product (natural resistance associated macrophage protein 2, Nramp2) encoded by the gene Nramp2 acts as an Fe transporter involved in the uptake of Fe from transferrin (Tf) and low Mr Fe complexes. Interestingly, there are two splice variants of Nram...

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Veröffentlicht in:	European journal of biochemistry 1999-07, Vol.263 (1), p.41-50
Hauptverfasser:	Wardrop, S. L., Richardson, D. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Animals Base Sequence Biological Transport, Active - drug effects Carrier Proteins - genetics Carrier Proteins - metabolism Cation Transport Proteins Cell Line Chelating Agents - pharmacology Deferoxamine - pharmacology desferrioxamine DNA Primers - genetics ferric ammonium citrate Ferric Compounds - pharmacology Gene Expression - drug effects Intracellular Fluid - metabolism iron Iron - metabolism iron transport Iron-Binding Proteins Iron-Regulatory Proteins Iron-Sulfur Proteins - genetics Iron-Sulfur Proteins - metabolism Kinetics Membrane Proteins - genetics Membrane Proteins - metabolism Mice Molecular Sequence Data natural resistance associated macrophage protein 2 Nitric Oxide - metabolism Nitric Oxide Donors - pharmacology nitrogen monoxide nontransferrin‐bound iron Nramp2 Nramp2 gene Nucleic Acid Conformation Penicillamine - analogs & derivatives Penicillamine - pharmacology Quaternary Ammonium Compounds - pharmacology Receptors, Transferrin - genetics RNA, Messenger - chemistry RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism S-nitroso-N-acetylpenicillamine Transferrin - metabolism transferrin receptors
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