High endothelial cells synthesize and degrade sLex. Putative implications for L-selectin-dependent recognition

L-selectin guides lymphocytes into peripheral lymphoid tissues by recognizing glycoprotein ligands decorated with 6-sulfated sialyl Lewis x (sulfo sLex). Here we have used a rat peripheral lymph node high endothelial cell line (Ax) to study in detail the synthesis, expression and degradation of sLex...

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Veröffentlicht in:	FEBS letters 1999-07, Vol.455 (1), p.97-100
Hauptverfasser:	Majuri, Marja-Leena, Räbinä, Jarkko, Niittymäki, Jaana, Tiisala, Sinikka, Mattila, Pirkko, Aavik, Einari, Miyasaka, Masayuki, Renkonen, Ossi, Renkonen, Risto
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Carbohydrate Sequence Cell Line CHO Cells Cricetinae DNA Endothelium Endothelium - cytology Endothelium - metabolism Fuc, fucose Fuc-T, fucosyltransferase Fucosyltransferases - genetics Fucosyltransferases - metabolism Gal, galactose GlcNAc, N-acetylglucosamine HEV, high endothelial venule Inflammation L-Selectin - metabolism Lex, Lewis x Molecular Sequence Data NeuNAc, N-acetylneuraminic acid Oligosaccharides - biosynthesis Oligosaccharides - chemistry Oligosaccharides - metabolism Protein Binding Rats RNA, Messenger - genetics Sequence Homology, Nucleic Acid Sialyl Lewis x sLex, sialyl Lewis x α(1,3)fucosyltransferase α(2,3)sialidase
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