GEFs: structural basis for their activation of small GTP-binding proteins

Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. Guanine-nucleotide-exchange factors (GEFs) positively regulate these GTP-binding proteins in response to a variety...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Trends in Biochemical Sciences 1999-08, Vol.24 (8), p.306-311
Hauptverfasser:	Cherfils, Jacqueline, Chardin, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Cycle Proteins - chemistry Cell Cycle Proteins - metabolism Drug Design G proteins GTP-Binding Proteins - metabolism Guanine Nucleotide Exchange Factors Humans Models, Molecular Protein Conformation Proteins - chemistry Proteins - metabolism ras Guanine Nucleotide Exchange Factors ras-GRF1 Small GTP-binding proteins
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!