Clinicopathological correlation of blistering diseases of skin
Blistering diseases are alarming skin conditions where blister formation occurs in various ways and cannot be differentiated clinically. For confirmation of diagnosis, along with routine histological examination, immunofluorescence study is essential. Tzanck smear may be used as a rapid diagnostic t...
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| Veröffentlicht in: | Bangladesh Medical Research Council bulletin 2008-08, Vol.34 (2), p.48-53 |
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| creator | Kabir, A K M Nurul Kamal, Mohammed Choudhury, Aga Masood |
| description | Blistering diseases are alarming skin conditions where blister formation occurs in various ways and cannot be differentiated clinically. For confirmation of diagnosis, along with routine histological examination, immunofluorescence study is essential. Tzanck smear may be used as a rapid diagnostic tool. We included here 34 cases of different blistering lesions. Other than routine Hematoxylin and Eosin stain, direct immunofluorescence test was done in 31 cases, indirect immunofluorescence in 28 cases and Tzanck smear in 33 cases. Direct immunofluorescence stain was also applied on Tzanck smears. The most frequent diagnoses were pemphigus (n = 16), bullous pemphigoid (n = 11) and linear IgA dermatosis (n = 3). Clinical findings and histological examination were sufficient for the diagnosis of most cases. Direct immunofluorescence study is essential in many cases, and indirect immunofluorescence study is a useful method for diagnosis of some of the blistering diseases, especially in pemphigus. Direct immunofluorescence staining on Tzanck smear is a novel technique for the diagnosis of pemphigus. |
| doi_str_mv | 10.3329/bmrcb.v34i2.1175 |
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For confirmation of diagnosis, along with routine histological examination, immunofluorescence study is essential. Tzanck smear may be used as a rapid diagnostic tool. We included here 34 cases of different blistering lesions. Other than routine Hematoxylin and Eosin stain, direct immunofluorescence test was done in 31 cases, indirect immunofluorescence in 28 cases and Tzanck smear in 33 cases. Direct immunofluorescence stain was also applied on Tzanck smears. The most frequent diagnoses were pemphigus (n = 16), bullous pemphigoid (n = 11) and linear IgA dermatosis (n = 3). Clinical findings and histological examination were sufficient for the diagnosis of most cases. Direct immunofluorescence study is essential in many cases, and indirect immunofluorescence study is a useful method for diagnosis of some of the blistering diseases, especially in pemphigus. 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For confirmation of diagnosis, along with routine histological examination, immunofluorescence study is essential. Tzanck smear may be used as a rapid diagnostic tool. We included here 34 cases of different blistering lesions. Other than routine Hematoxylin and Eosin stain, direct immunofluorescence test was done in 31 cases, indirect immunofluorescence in 28 cases and Tzanck smear in 33 cases. Direct immunofluorescence stain was also applied on Tzanck smears. The most frequent diagnoses were pemphigus (n = 16), bullous pemphigoid (n = 11) and linear IgA dermatosis (n = 3). Clinical findings and histological examination were sufficient for the diagnosis of most cases. Direct immunofluorescence study is essential in many cases, and indirect immunofluorescence study is a useful method for diagnosis of some of the blistering diseases, especially in pemphigus. Direct immunofluorescence staining on Tzanck smear is a novel technique for the diagnosis of pemphigus.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Autoimmune Diseases - diagnosis</subject><subject>Blister - diagnosis</subject><subject>Blister - etiology</subject><subject>Blister - pathology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Fluorescent Antibody Technique, Direct</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Skin Diseases - diagnosis</subject><subject>Skin Diseases - physiopathology</subject><subject>Young Adult</subject><issn>0377-9238</issn><issn>2224-7238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1LxDAQxYMo7rLu3ZP05K1rkmmb5iLI4qqw4EHvIU2nazRt1qQr-N-b_QDnMh-89xh-hFwzugDg8q7pg2kWP1BYvmBMlGdkyjkvcsGhPidTCkLkMs0TMo_xk6ZKLijhkkyYZEyWIKfkfunsYI3f6vHDO7-xRrvM-BDQ6dH6IfNd1jgbRwx22GStjagjxv05ftnhilx02kWcn_qMvK0e35fP-fr16WX5sM4NZ3zMATmKFkpWoa4QKgmtlC3DktYFrTkFzUTD00tdQcu66ASYruJp04wbATNye0zdBv-9wziq3kaDzukB_S6qSkqgFdRJSI9CE3yMATu1DbbX4VcxqvbQ1AGaOkBTe2jJcnPK3jU9tv-GEyL4AxL8aN4</recordid><startdate>200808</startdate><enddate>200808</enddate><creator>Kabir, A K M Nurul</creator><creator>Kamal, Mohammed</creator><creator>Choudhury, Aga Masood</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200808</creationdate><title>Clinicopathological correlation of blistering diseases of skin</title><author>Kabir, A K M Nurul ; Kamal, Mohammed ; Choudhury, Aga Masood</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c212t-3e2e7d3516ea6e3693d99d1e508408203a17b2195f40584f73cf625f4a12c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Autoimmune Diseases - diagnosis</topic><topic>Blister - diagnosis</topic><topic>Blister - etiology</topic><topic>Blister - pathology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Fluorescent Antibody Technique, Direct</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Skin Diseases - diagnosis</topic><topic>Skin Diseases - physiopathology</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>Kabir, A K M Nurul</creatorcontrib><creatorcontrib>Kamal, Mohammed</creatorcontrib><creatorcontrib>Choudhury, Aga Masood</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bangladesh Medical Research Council bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kabir, A K M Nurul</au><au>Kamal, Mohammed</au><au>Choudhury, Aga Masood</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinicopathological correlation of blistering diseases of skin</atitle><jtitle>Bangladesh Medical Research Council bulletin</jtitle><addtitle>Bangladesh Med Res Counc Bull</addtitle><date>2008-08</date><risdate>2008</risdate><volume>34</volume><issue>2</issue><spage>48</spage><epage>53</epage><pages>48-53</pages><issn>0377-9238</issn><eissn>2224-7238</eissn><abstract>Blistering diseases are alarming skin conditions where blister formation occurs in various ways and cannot be differentiated clinically. For confirmation of diagnosis, along with routine histological examination, immunofluorescence study is essential. Tzanck smear may be used as a rapid diagnostic tool. We included here 34 cases of different blistering lesions. Other than routine Hematoxylin and Eosin stain, direct immunofluorescence test was done in 31 cases, indirect immunofluorescence in 28 cases and Tzanck smear in 33 cases. Direct immunofluorescence stain was also applied on Tzanck smears. The most frequent diagnoses were pemphigus (n = 16), bullous pemphigoid (n = 11) and linear IgA dermatosis (n = 3). Clinical findings and histological examination were sufficient for the diagnosis of most cases. Direct immunofluorescence study is essential in many cases, and indirect immunofluorescence study is a useful method for diagnosis of some of the blistering diseases, especially in pemphigus. 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| source | MEDLINE; Bangladesh Journals Online; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Aged Autoimmune Diseases - diagnosis Blister - diagnosis Blister - etiology Blister - pathology Child Child, Preschool Female Fluorescent Antibody Technique, Direct Humans Male Middle Aged Skin Diseases - diagnosis Skin Diseases - physiopathology Young Adult |
| title | Clinicopathological correlation of blistering diseases of skin |
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