Formylation Is Not Essential for Initiation of Protein Synthesis in All Eubacteria

Formylation of the initiator methionyl-tRNA, catalyzed by methionyl-tRNA formyltransferase, has long been regarded as essential for initiation of protein synthesis in eubacteria. Here, we show that this process is, in fact, dispensable in Pseudomonas aeruginosa . Disruption of the chromosomal methio...

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Veröffentlicht in:	The Journal of biological chemistry 1999-08, Vol.274 (32), p.22143-22146
Hauptverfasser:	Newton, D T, Creuzenet, C, Mangroo, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylation Base Sequence Escherichia coli Escherichia coli - enzymology Eubacteria Eubacterium Genes, Bacterial Hydroxymethyl and Formyl Transferases - genetics Hydroxymethyl and Formyl Transferases - metabolism Molecular Sequence Data Mutation Nucleic Acid Conformation Peptide Chain Initiation, Translational Phenotype Pseudomonas aeruginosa Pseudomonas aeruginosa - enzymology RNA, Transfer, Met - metabolism
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