Enantioselectivity in the steady-state pharmacokinetics of metoprolol in hypertensive patients

In the present study we investigated the enantioselectivity in the pharmacokinetics of metoprolol administered in a multiple‐dose regimen as the racemate. The study was conducted on 10 patients of both sexes with mild to severe essential hypertension, aged 28 to 76 years, with normal hepatic and ren...

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Veröffentlicht in:	Chirality (New York, N.Y.) N.Y.), 1999, Vol.11 (7), p.591-597
Hauptverfasser:	Cerqueira, Paula Macedo, Cesarino, Evandro José, Mateus, Fabiano Henrique, Mere Jr, Yussif, Santos, Silvia Regina Cavani Jorge, Lanchote, Vera Lucia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antihypertensive Agents - pharmacokinetics Area Under Curve Debrisoquin - analogs & derivatives Debrisoquin - urine enantiomers Female Half-Life Humans hypertension Hypertension - metabolism Male metoprolol Metoprolol - blood Metoprolol - pharmacokinetics Middle Aged patients pharmacokinetics Phenotype Stereoisomerism
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