Genetic testing of breast and ovarian cancer patients: clinical characteristics and hormonal risk modifiers

Objectives: Carriers of the mutations 185delAG and 5382insC in the BRCA1 gene and 6174delT in the BRCA2 gene have a substantial life-time risk for breast and ovarian cancers (BC and OC). The aim of the study was to identify the clinical features and the hormonal risk modifiers in mutation carriers a...

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Veröffentlicht in:	European journal of obstetrics & gynecology and reproductive biology 1999-07, Vol.85 (1), p.75-80
Hauptverfasser:	Kaduri, Luna, Gibs, Maya, Hubert, Ayala, Sagi, Michal, Heching, Norman, Lerer, Israela, Uziely, Bietrice, Weinberg, Naomi, Abeliovich, Dvorah, Peretz, Tamar
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Aged Ashkenazi founder mutations Biological and medical sciences BRCA1/2 BRCA2 Protein Breast cancer Breast Neoplasms - genetics Female Female genital diseases Genes, BRCA1 Genetic Carrier Screening Gynecology. Andrology. Obstetrics Hormonal effects Humans Medical sciences Menarche Menopause Middle Aged Mutation Neoplasm Proteins - genetics Ovarian cancer Ovarian Neoplasms - genetics Pregnancy Prevention Transcription Factors - genetics Tropical medicine Tumors
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