Antitumor Activity of Phenylahistin in Vitro and in Vivo
Phenylahistin is a new cell cycle inhibitor produced by Aspergillus ustus. Since phenylahistin was produced as a scalemic mixture of (-)-phenylahistin and its enantiomer, we separated each enantiomer and evaluated their antitumor activity in vitro. (-)-Phenylahistin exhibited antitumor activity agai...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1999-06, Vol.63 (6), p.1130-1133 |
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| container_issue | 6 |
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| container_title | Bioscience, biotechnology, and biochemistry |
| container_volume | 63 |
| creator | KANOH, Kaneo KOHNO, Shinkichi KATADA, Jun HAYASHI, Yoshio MURAMATSU, Michiko UNO, Isao |
| description | Phenylahistin is a new cell cycle inhibitor produced by Aspergillus ustus. Since phenylahistin was produced as a scalemic mixture of (-)-phenylahistin and its enantiomer, we separated each enantiomer and evaluated their antitumor activity in vitro. (-)-Phenylahistin exhibited antitumor activity against 8 tumor cell lines with IC
50
values ranging from 1.8×10
-7
to 3.7×10
-6
, while (+)-phenylahistin exhibited 33-100-fold less potent activity than (-)-phenylahistin did. (-)-Phenylahistin also showed antitumor activity against P388 leukemia and Lewis lung carcinoma cells in vivo. |
| doi_str_mv | 10.1271/bbb.63.1130 |
| format | Article |
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50
values ranging from 1.8×10
-7
to 3.7×10
-6
, while (+)-phenylahistin exhibited 33-100-fold less potent activity than (-)-phenylahistin did. (-)-Phenylahistin also showed antitumor activity against P388 leukemia and Lewis lung carcinoma cells in vivo.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.63.1130</identifier><identifier>PMID: 10427703</identifier><language>eng</language><publisher>Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry</publisher><subject>Animals ; Antibiotics, Antineoplastic - pharmacology ; antitumor activity ; Biological and medical sciences ; Carcinoma, Lewis Lung - drug therapy ; Cell Cycle - drug effects ; cell cycle inhibitor ; Diketopiperazines ; enantiomers ; General pharmacology ; Leukemia P388 - drug therapy ; Male ; Medical sciences ; Mice ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; phenylahistin ; Piperazines - pharmacology ; Stereoisomerism ; Tumor Cells, Cultured</subject><ispartof>Bioscience, biotechnology, and biochemistry, 1999-06, Vol.63 (6), p.1130-1133</ispartof><rights>1999 by Japan Society for Bioscience, Biotechnology, and Agrochemistry 1999</rights><rights>1999 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-cd8efaa65020df292496d02d643cc5574df613a509412ab2d810c756bf4ff5153</citedby><cites>FETCH-LOGICAL-c447t-cd8efaa65020df292496d02d643cc5574df613a509412ab2d810c756bf4ff5153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1977087$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10427703$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KANOH, Kaneo</creatorcontrib><creatorcontrib>KOHNO, Shinkichi</creatorcontrib><creatorcontrib>KATADA, Jun</creatorcontrib><creatorcontrib>HAYASHI, Yoshio</creatorcontrib><creatorcontrib>MURAMATSU, Michiko</creatorcontrib><creatorcontrib>UNO, Isao</creatorcontrib><title>Antitumor Activity of Phenylahistin in Vitro and in Vivo</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>Phenylahistin is a new cell cycle inhibitor produced by Aspergillus ustus. Since phenylahistin was produced as a scalemic mixture of (-)-phenylahistin and its enantiomer, we separated each enantiomer and evaluated their antitumor activity in vitro. (-)-Phenylahistin exhibited antitumor activity against 8 tumor cell lines with IC
50
values ranging from 1.8×10
-7
to 3.7×10
-6
, while (+)-phenylahistin exhibited 33-100-fold less potent activity than (-)-phenylahistin did. (-)-Phenylahistin also showed antitumor activity against P388 leukemia and Lewis lung carcinoma cells in vivo.</description><subject>Animals</subject><subject>Antibiotics, Antineoplastic - pharmacology</subject><subject>antitumor activity</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Lewis Lung - drug therapy</subject><subject>Cell Cycle - drug effects</subject><subject>cell cycle inhibitor</subject><subject>Diketopiperazines</subject><subject>enantiomers</subject><subject>General pharmacology</subject><subject>Leukemia P388 - drug therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>phenylahistin</subject><subject>Piperazines - pharmacology</subject><subject>Stereoisomerism</subject><subject>Tumor Cells, Cultured</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0E1LBCEYB3CJoratU_cYKLrEbDq-jccleoOgDtVVHB3JmBlLnWK_fcZsFJEI8sjPh8c_AAcILlDF0VnTNAuGFwhhuAFmCBNeMkH4JphBgVhZE4p2wG6MLxDmC4q2wQ6CpOIc4hmol0Nyaex9KJY6uXeXVoW3xf1zO6w69exickOR95NLwRdqMFPx7vfAllVdbPfX5xw8Xl48nF-Xt3dXN-fL21ITwlOpTd1apRiFFTS2EhURzMDKMIK1ppQTYxnCikJBUKWaytQIak5ZY4m1FFE8BydT39fg38Y2Jtm7qNuuU0PrxyiZyD1xXnNw9Ae--DEMeTaJCBEEU5F_PAenk9LBxxhaK1-D61VYSQTlV5wyxykZll9xZn247jk2fWt-2Sm_DI7XQEWtOhvUoF38cSKrmmfGJuYG60OvPnzojExq1fnw_Qb_N8AnksuNHQ</recordid><startdate>19990601</startdate><enddate>19990601</enddate><creator>KANOH, Kaneo</creator><creator>KOHNO, Shinkichi</creator><creator>KATADA, Jun</creator><creator>HAYASHI, Yoshio</creator><creator>MURAMATSU, Michiko</creator><creator>UNO, Isao</creator><general>Japan Society for Bioscience, Biotechnology, and Agrochemistry</general><general>Japan Society for Bioscience Biotechnology and Agrochemistry</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990601</creationdate><title>Antitumor Activity of Phenylahistin in Vitro and in Vivo</title><author>KANOH, Kaneo ; KOHNO, Shinkichi ; KATADA, Jun ; HAYASHI, Yoshio ; MURAMATSU, Michiko ; UNO, Isao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-cd8efaa65020df292496d02d643cc5574df613a509412ab2d810c756bf4ff5153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Antibiotics, Antineoplastic - pharmacology</topic><topic>antitumor activity</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Lewis Lung - drug therapy</topic><topic>Cell Cycle - drug effects</topic><topic>cell cycle inhibitor</topic><topic>Diketopiperazines</topic><topic>enantiomers</topic><topic>General pharmacology</topic><topic>Leukemia P388 - drug therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>phenylahistin</topic><topic>Piperazines - pharmacology</topic><topic>Stereoisomerism</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KANOH, Kaneo</creatorcontrib><creatorcontrib>KOHNO, Shinkichi</creatorcontrib><creatorcontrib>KATADA, Jun</creatorcontrib><creatorcontrib>HAYASHI, Yoshio</creatorcontrib><creatorcontrib>MURAMATSU, Michiko</creatorcontrib><creatorcontrib>UNO, Isao</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KANOH, Kaneo</au><au>KOHNO, Shinkichi</au><au>KATADA, Jun</au><au>HAYASHI, Yoshio</au><au>MURAMATSU, Michiko</au><au>UNO, Isao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antitumor Activity of Phenylahistin in Vitro and in Vivo</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>1999-06-01</date><risdate>1999</risdate><volume>63</volume><issue>6</issue><spage>1130</spage><epage>1133</epage><pages>1130-1133</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>Phenylahistin is a new cell cycle inhibitor produced by Aspergillus ustus. Since phenylahistin was produced as a scalemic mixture of (-)-phenylahistin and its enantiomer, we separated each enantiomer and evaluated their antitumor activity in vitro. (-)-Phenylahistin exhibited antitumor activity against 8 tumor cell lines with IC
50
values ranging from 1.8×10
-7
to 3.7×10
-6
, while (+)-phenylahistin exhibited 33-100-fold less potent activity than (-)-phenylahistin did. (-)-Phenylahistin also showed antitumor activity against P388 leukemia and Lewis lung carcinoma cells in vivo.</abstract><cop>Tokyo</cop><pub>Japan Society for Bioscience, Biotechnology, and Agrochemistry</pub><pmid>10427703</pmid><doi>10.1271/bbb.63.1130</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0916-8451 |
| ispartof | Bioscience, biotechnology, and biochemistry, 1999-06, Vol.63 (6), p.1130-1133 |
| issn | 0916-8451 1347-6947 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69924333 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Open Access Titles of Japan; Free Full-Text Journals in Chemistry |
| subjects | Animals Antibiotics, Antineoplastic - pharmacology antitumor activity Biological and medical sciences Carcinoma, Lewis Lung - drug therapy Cell Cycle - drug effects cell cycle inhibitor Diketopiperazines enantiomers General pharmacology Leukemia P388 - drug therapy Male Medical sciences Mice Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phenylahistin Piperazines - pharmacology Stereoisomerism Tumor Cells, Cultured |
| title | Antitumor Activity of Phenylahistin in Vitro and in Vivo |
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