Twice-daily versus once-daily morphine sulphate controlled-release suppositories for the treatment of cancer pain : A randomized controlled trial

We evaluated the safety and efficacy of controlled-release morphine sulphate suppositories administered 12-hourly and once daily in patients with chronic cancer in a randomized double-blind crossover trial. Pain was assessed using a 100-mm VAS pain scale and a five-point ordinal pain scale. The VAS...

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Veröffentlicht in:	Supportive care in cancer 1999-07, Vol.7 (4), p.280-283
Hauptverfasser:	BRUERA, E, BELZILE, M, NEUMANN, C. M, FORD, I, HARSANYI, Z, DARKE, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Analgesics, Opioid - administration & dosage Biological and medical sciences Clinical trials Cross-Over Studies Delayed-Action Preparations - administration & dosage Dose-Response Relationship, Drug Double-Blind Method Drug Administration Schedule Female Humans Male Medical sciences Medical treatment Middle Aged Morphine - administration & dosage Neoplasms - complications Neoplasms - diagnosis Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pain Pain Measurement Pain, Intractable - drug therapy Pain, Intractable - etiology Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Suppositories - administration & dosage Treatment Outcome
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