Design and Synthesis of Isoxazoline Derivatives as Factor Xa Inhibitors. 2

Intravascular clot formation is an important factor in a number of cardiovascular diseases. Therefore, the prevention of blood coagulation has become a major target for new therapeutic agents. One attractive approach is the inhibition of factor Xa (FXa), the enzyme directly responsible for thrombin...

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Veröffentlicht in:	Journal of medicinal chemistry 1999-07, Vol.42 (15), p.2760-2773
Hauptverfasser:	Quan, Mimi L, Ellis, Christopher D, Liauw, Ann Y, Alexander, Richard S, Knabb, Robert M, Lam, Gilbert, Wright, Matthew R, Wong, Pancras C, Wexler, Ruth R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arteriovenous Shunt, Surgical Binding Sites Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Crystallography, X-Ray Dogs Factor Xa Inhibitors Fibrinolytic Agents - chemical synthesis Fibrinolytic Agents - chemistry Fibrinolytic Agents - pharmacology Humans Isoxazoles - chemical synthesis Isoxazoles - chemistry Isoxazoles - pharmacology Medical sciences Models, Molecular Pharmacology. Drug treatments Rabbits Structure-Activity Relationship Tetrazoles - chemical synthesis Tetrazoles - chemistry Tetrazoles - pharmacology Thrombin - antagonists & inhibitors Thrombosis - drug therapy Trypsin - metabolism Trypsin Inhibitors - chemical synthesis Trypsin Inhibitors - chemistry Trypsin Inhibitors - pharmacokinetics Trypsin Inhibitors - pharmacology
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