Use of Recombinant Human Bone Morphogenetic Protein-2 to Enhance Tendon Healing in a Bone Tunnel
This study examines the hypothesis that recombinant human bone morphogenetic protein-2 can enhance bone ingrowth into a tendon graft placed into a bone tunnel. We transplanted the long digital extensor tendon into a drill hole in the proximal tibia in 65 adult mongrel dogs. We applied two different...
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| Veröffentlicht in: | The American journal of sports medicine 1999-07, Vol.27 (4), p.476-488 |
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| container_title | The American journal of sports medicine |
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| creator | Rodeo, Scott A. Suzuki, Katsunori Deng, Xiang-hua Wozney, John Warren, Russell F. |
| description | This study examines the hypothesis that recombinant human bone morphogenetic protein-2 can enhance bone ingrowth into a tendon
graft placed into a bone tunnel. We transplanted the long digital extensor tendon into a drill hole in the proximal tibia
in 65 adult mongrel dogs. We applied two different doses of the bone morphogenetic protein to the tendon-bone interface in
one limb using an absorbable type I collagen sponge carrier and only the collagen sponge to the contralateral (control) limb.
The healed tendon-bone attachment was evaluated at serial times between 3 days and 8 weeks using radiography, histologic examination,
and biomechanical testing. At all time points, histologic and radiographic examination demonstrated more extensive bone formation
around the tendon with closer apposition of new bone to the tendon in the protein-treated limb than in the paired control
limb. Biomechanical testing demonstrated higher tendon pull-out strength in the protein-treated side at all time points, with
a statistically significant difference between the low-dose-treated side and the control side at 2 weeks. The histologic and
biomechanical data suggested superior healing at the lower protein dose. This study demonstrated that bone morphogenetic protein
can accelerate the healing process when a tendon graft is transplanted into a bone tunnel. |
| doi_str_mv | 10.1177/03635465990270041201 |
| format | Article |
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graft placed into a bone tunnel. We transplanted the long digital extensor tendon into a drill hole in the proximal tibia
in 65 adult mongrel dogs. We applied two different doses of the bone morphogenetic protein to the tendon-bone interface in
one limb using an absorbable type I collagen sponge carrier and only the collagen sponge to the contralateral (control) limb.
The healed tendon-bone attachment was evaluated at serial times between 3 days and 8 weeks using radiography, histologic examination,
and biomechanical testing. At all time points, histologic and radiographic examination demonstrated more extensive bone formation
around the tendon with closer apposition of new bone to the tendon in the protein-treated limb than in the paired control
limb. Biomechanical testing demonstrated higher tendon pull-out strength in the protein-treated side at all time points, with
a statistically significant difference between the low-dose-treated side and the control side at 2 weeks. The histologic and
biomechanical data suggested superior healing at the lower protein dose. This study demonstrated that bone morphogenetic protein
can accelerate the healing process when a tendon graft is transplanted into a bone tunnel.</description><identifier>ISSN: 0363-5465</identifier><identifier>EISSN: 1552-3365</identifier><identifier>DOI: 10.1177/03635465990270041201</identifier><identifier>PMID: 10424218</identifier><identifier>CODEN: AJSMDO</identifier><language>eng</language><publisher>Los Angeles, CA: American Orthopaedic Society for Sports Medicine</publisher><subject>Animals ; Biological and medical sciences ; Biomechanical Phenomena ; Bone Morphogenetic Protein 2 ; Bone Morphogenetic Proteins - therapeutic use ; Bones ; Dogs ; Health aspects ; Injuries ; Medical sciences ; Pilot Projects ; Proteins ; Recombinant Proteins ; Sports injuries ; Sports medicine ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology. Biomaterials. Equipments ; Tendon injuries ; Tendons ; Tendons - pathology ; Tendons - transplantation ; Transforming Growth Factor beta - therapeutic use ; Transplantation, Autologous ; Wound Healing - physiology</subject><ispartof>The American journal of sports medicine, 1999-07, Vol.27 (4), p.476-488</ispartof><rights>1999 INIST-CNRS</rights><rights>Copyright American Journal of Sports Medicine Jul/Aug 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c565t-378e7d1babf731ba3eebe89591b25b54dfb4fb6f37be5eb2c35700640c9f783a3</citedby><cites>FETCH-LOGICAL-c565t-378e7d1babf731ba3eebe89591b25b54dfb4fb6f37be5eb2c35700640c9f783a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/03635465990270041201$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/03635465990270041201$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1905211$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10424218$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodeo, Scott A.</creatorcontrib><creatorcontrib>Suzuki, Katsunori</creatorcontrib><creatorcontrib>Deng, Xiang-hua</creatorcontrib><creatorcontrib>Wozney, John</creatorcontrib><creatorcontrib>Warren, Russell F.</creatorcontrib><title>Use of Recombinant Human Bone Morphogenetic Protein-2 to Enhance Tendon Healing in a Bone Tunnel</title><title>The American journal of sports medicine</title><addtitle>Am J Sports Med</addtitle><description>This study examines the hypothesis that recombinant human bone morphogenetic protein-2 can enhance bone ingrowth into a tendon
graft placed into a bone tunnel. We transplanted the long digital extensor tendon into a drill hole in the proximal tibia
in 65 adult mongrel dogs. We applied two different doses of the bone morphogenetic protein to the tendon-bone interface in
one limb using an absorbable type I collagen sponge carrier and only the collagen sponge to the contralateral (control) limb.
The healed tendon-bone attachment was evaluated at serial times between 3 days and 8 weeks using radiography, histologic examination,
and biomechanical testing. At all time points, histologic and radiographic examination demonstrated more extensive bone formation
around the tendon with closer apposition of new bone to the tendon in the protein-treated limb than in the paired control
limb. Biomechanical testing demonstrated higher tendon pull-out strength in the protein-treated side at all time points, with
a statistically significant difference between the low-dose-treated side and the control side at 2 weeks. The histologic and
biomechanical data suggested superior healing at the lower protein dose. This study demonstrated that bone morphogenetic protein
can accelerate the healing process when a tendon graft is transplanted into a bone tunnel.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomechanical Phenomena</subject><subject>Bone Morphogenetic Protein 2</subject><subject>Bone Morphogenetic Proteins - therapeutic use</subject><subject>Bones</subject><subject>Dogs</subject><subject>Health aspects</subject><subject>Injuries</subject><subject>Medical sciences</subject><subject>Pilot Projects</subject><subject>Proteins</subject><subject>Recombinant Proteins</subject><subject>Sports injuries</subject><subject>Sports medicine</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology. Biomaterials. Equipments</subject><subject>Tendon injuries</subject><subject>Tendons</subject><subject>Tendons - pathology</subject><subject>Tendons - transplantation</subject><subject>Transforming Growth Factor beta - therapeutic use</subject><subject>Transplantation, Autologous</subject><subject>Wound Healing - physiology</subject><issn>0363-5465</issn><issn>1552-3365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV-LEzEUxQdR3Lr6DUSCuD45mr-TyeNaViusrEj3OSbpnTYlk9TJDK7f3pQpKiLs0335nXvPuaeqnhP8lhAp32HWMMEboRSmEmNOKCYPqgURgtaMNeJhtTgi9ZE5q57kvMcYE9m0j6szgjnllLSL6tttBpQ69BVc6q2PJo5oNfUmovcpAvqchsMubSHC6B36MqQRfKwpGhO6ijsTHaA1xE2KaAUm-LhFPiIza9dTjBCeVo86EzI8O83z6vbD1Xq5qq9vPn5aXl7XTjRirJlsQW6INbaTrAwGYKFVQhFLhRV801ne2aZj0oIASx0TJXTDsVOdbJlh59Xree9hSN8nyKPufXYQgomQpqwbpShljN8LkrZtVEtxAV_-A-7TNMQSQlMisWg5pwV6M0NbE0D76FIc4W50KQTYgi4Rlzf6UghOyvNVwfmMuyHlPECnD4PvzfBTE6yPter_1VpkL05WJtvD5i_R3GMBXp0Ak50J3VCq8fkPp7Cg5LiHzFg2xdzvOPfcvpg1O7_d_fAD6NybEIoTps0-U6m55rJhvwAGSMGv</recordid><startdate>19990701</startdate><enddate>19990701</enddate><creator>Rodeo, Scott A.</creator><creator>Suzuki, Katsunori</creator><creator>Deng, Xiang-hua</creator><creator>Wozney, John</creator><creator>Warren, Russell F.</creator><general>American Orthopaedic Society for Sports Medicine</general><general>SAGE Publications</general><general>Sage Publications, Inc</general><general>Sage Publications Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>19990701</creationdate><title>Use of Recombinant Human Bone Morphogenetic Protein-2 to Enhance Tendon Healing in a Bone Tunnel</title><author>Rodeo, Scott A. ; Suzuki, Katsunori ; Deng, Xiang-hua ; Wozney, John ; Warren, Russell F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c565t-378e7d1babf731ba3eebe89591b25b54dfb4fb6f37be5eb2c35700640c9f783a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biomechanical Phenomena</topic><topic>Bone Morphogenetic Protein 2</topic><topic>Bone Morphogenetic Proteins - therapeutic use</topic><topic>Bones</topic><topic>Dogs</topic><topic>Health aspects</topic><topic>Injuries</topic><topic>Medical sciences</topic><topic>Pilot Projects</topic><topic>Proteins</topic><topic>Recombinant Proteins</topic><topic>Sports injuries</topic><topic>Sports medicine</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Technology. Biomaterials. Equipments</topic><topic>Tendon injuries</topic><topic>Tendons</topic><topic>Tendons - pathology</topic><topic>Tendons - transplantation</topic><topic>Transforming Growth Factor beta - therapeutic use</topic><topic>Transplantation, Autologous</topic><topic>Wound Healing - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodeo, Scott A.</creatorcontrib><creatorcontrib>Suzuki, Katsunori</creatorcontrib><creatorcontrib>Deng, Xiang-hua</creatorcontrib><creatorcontrib>Wozney, John</creatorcontrib><creatorcontrib>Warren, Russell F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of sports medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodeo, Scott A.</au><au>Suzuki, Katsunori</au><au>Deng, Xiang-hua</au><au>Wozney, John</au><au>Warren, Russell F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of Recombinant Human Bone Morphogenetic Protein-2 to Enhance Tendon Healing in a Bone Tunnel</atitle><jtitle>The American journal of sports medicine</jtitle><addtitle>Am J Sports Med</addtitle><date>1999-07-01</date><risdate>1999</risdate><volume>27</volume><issue>4</issue><spage>476</spage><epage>488</epage><pages>476-488</pages><issn>0363-5465</issn><eissn>1552-3365</eissn><coden>AJSMDO</coden><abstract>This study examines the hypothesis that recombinant human bone morphogenetic protein-2 can enhance bone ingrowth into a tendon
graft placed into a bone tunnel. We transplanted the long digital extensor tendon into a drill hole in the proximal tibia
in 65 adult mongrel dogs. We applied two different doses of the bone morphogenetic protein to the tendon-bone interface in
one limb using an absorbable type I collagen sponge carrier and only the collagen sponge to the contralateral (control) limb.
The healed tendon-bone attachment was evaluated at serial times between 3 days and 8 weeks using radiography, histologic examination,
and biomechanical testing. At all time points, histologic and radiographic examination demonstrated more extensive bone formation
around the tendon with closer apposition of new bone to the tendon in the protein-treated limb than in the paired control
limb. Biomechanical testing demonstrated higher tendon pull-out strength in the protein-treated side at all time points, with
a statistically significant difference between the low-dose-treated side and the control side at 2 weeks. The histologic and
biomechanical data suggested superior healing at the lower protein dose. This study demonstrated that bone morphogenetic protein
can accelerate the healing process when a tendon graft is transplanted into a bone tunnel.</abstract><cop>Los Angeles, CA</cop><pub>American Orthopaedic Society for Sports Medicine</pub><pmid>10424218</pmid><doi>10.1177/03635465990270041201</doi><tpages>13</tpages></addata></record> |
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| source | MEDLINE; SAGE Complete; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Biomechanical Phenomena Bone Morphogenetic Protein 2 Bone Morphogenetic Proteins - therapeutic use Bones Dogs Health aspects Injuries Medical sciences Pilot Projects Proteins Recombinant Proteins Sports injuries Sports medicine Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Tendon injuries Tendons Tendons - pathology Tendons - transplantation Transforming Growth Factor beta - therapeutic use Transplantation, Autologous Wound Healing - physiology |
| title | Use of Recombinant Human Bone Morphogenetic Protein-2 to Enhance Tendon Healing in a Bone Tunnel |
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