Inhibitory effects of higenamine on dopamine content in PC12 cells

Abstract The inhibitory effects of (±)-higenamine, a benzyliso-quinoline alkaloid, on dopamine biosynthesis in PC12 cells were investigated. Higenamine decreased the intracellular dopamine content dose-dependently and showed 55.2% inhibition of dopamine content in PC12 cells at a concentration of 20...

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Veröffentlicht in:	Planta medica 1999-06, Vol.65 (5), p.452-455
Hauptverfasser:	Shin, J.S, Yun-Choi, H.S, Kim, E.I, Lee, M.K
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - pharmacology Animals application rate Berberine - pharmacology Biological and medical sciences biosynthesis calcium Cardiotonic agents Cardiotonic Agents - pharmacology Cardiovascular system cell lines chemical constituents of plants Dopamine - pharmacology dosage dose response enzyme inhibitors inhibition inorganic ions isoquinoline alkaloids Kinetics Letter Medical sciences neoplasms PC12 Cells Pharmacology. Drug treatments Rats Tetrahydroisoquinolines tyrosine 3-monooxygenase
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