4-Heterocyclohexanone-Based Inhibitors of the Serine Protease Plasmin

Three inhibitors that are based upon a 4-heterocyclohexanone nucleus were synthesized and evaluated for activity against the serine protease plasmin. Inhibitors of plasmin have potential as cancer chemotherapeutic agents that act by blocking both angiogenesis and metastasis. Inhibitor 1 has moderate...

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Veröffentlicht in:	Journal of medicinal chemistry 1999-07, Vol.42 (15), p.2969-2976
Hauptverfasser:	Sanders, Tanya C, Seto, Christopher T
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Binding Sites Biological and medical sciences Cyclohexanes - chemical synthesis Cyclohexanes - chemistry Fibrinolysin - antagonists & inhibitors General aspects Medical sciences Pharmacology. Drug treatments Serine Proteinase Inhibitors - chemical synthesis Serine Proteinase Inhibitors - chemistry Structure-Activity Relationship
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