new phenolic fatty acid ester with lipoxygenase inhibitory activity from Jacaranda filicifolia
Abstract The dichloromethane extract of the stem of JACARANDA FILICIFOLIA Don. showed inhibitory activity IN VITRO against soybean 5-lipoxygenase. Systematic fractionation to isolate the compounds responsible resulted in the isolation of three active compounds, 2α,3α-dihydroxyurs-12-en-28-oic acid,...
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| Veröffentlicht in: | Planta medica 1999-06, Vol.65 (5), p.455-457 |
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| container_title | Planta medica |
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| creator | Ali, R.M Houghton, P.J |
| description | Abstract
The dichloromethane extract of the stem of JACARANDA FILICIFOLIA Don. showed inhibitory activity IN VITRO against soybean 5-lipoxygenase. Systematic fractionation to isolate the compounds responsible resulted in the isolation of three active compounds, 2α,3α-dihydroxyurs-12-en-28-oic acid, β-sitosterol, and one of which was new which was characterised as 2-(4-hydroxyphenyl)ethyl 1-dodecyloctadecanoate. This type of compound has not previously been reported to inhibit lipoxygenase. |
| doi_str_mv | 10.1055/s-2006-960811 |
| format | Article |
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The dichloromethane extract of the stem of JACARANDA FILICIFOLIA Don. showed inhibitory activity IN VITRO against soybean 5-lipoxygenase. Systematic fractionation to isolate the compounds responsible resulted in the isolation of three active compounds, 2α,3α-dihydroxyurs-12-en-28-oic acid, β-sitosterol, and one of which was new which was characterised as 2-(4-hydroxyphenyl)ethyl 1-dodecyloctadecanoate. This type of compound has not previously been reported to inhibit lipoxygenase.</description><identifier>ISSN: 0032-0943</identifier><identifier>EISSN: 1439-0221</identifier><identifier>DOI: 10.1055/s-2006-960811</identifier><identifier>PMID: 10418336</identifier><identifier>CODEN: PLMEAA</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Biological and medical sciences ; chemical constituents of plants ; chemical structure ; enzyme inhibitors ; esters ; fatty acids ; fractionation ; General pharmacology ; Jacaranda ; Letter ; lipoxygenase ; Lipoxygenase Inhibitors - chemistry ; Lipoxygenase Inhibitors - isolation & purification ; Lipoxygenase Inhibitors - pharmacology ; Medical sciences ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; phenolic compounds ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plant Stems ; Plants, Medicinal ; Stearates - chemistry ; Stearates - isolation & purification ; Stearates - pharmacology ; stems</subject><ispartof>Planta medica, 1999-06, Vol.65 (5), p.455-457</ispartof><rights>Georg Thieme Verlag Stuttgart · New York</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-3d51d7cbb147142bbce002ed612c48acf7d23f245643017bfb1b4da9b06b2d503</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2006-960811.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><link.rule.ids>314,780,784,3017,3018,27924,27925,54559</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1833109$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10418336$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ali, R.M</creatorcontrib><creatorcontrib>Houghton, P.J</creatorcontrib><title>new phenolic fatty acid ester with lipoxygenase inhibitory activity from Jacaranda filicifolia</title><title>Planta medica</title><addtitle>Planta Med</addtitle><description>Abstract
The dichloromethane extract of the stem of JACARANDA FILICIFOLIA Don. showed inhibitory activity IN VITRO against soybean 5-lipoxygenase. Systematic fractionation to isolate the compounds responsible resulted in the isolation of three active compounds, 2α,3α-dihydroxyurs-12-en-28-oic acid, β-sitosterol, and one of which was new which was characterised as 2-(4-hydroxyphenyl)ethyl 1-dodecyloctadecanoate. This type of compound has not previously been reported to inhibit lipoxygenase.</description><subject>Biological and medical sciences</subject><subject>chemical constituents of plants</subject><subject>chemical structure</subject><subject>enzyme inhibitors</subject><subject>esters</subject><subject>fatty acids</subject><subject>fractionation</subject><subject>General pharmacology</subject><subject>Jacaranda</subject><subject>Letter</subject><subject>lipoxygenase</subject><subject>Lipoxygenase Inhibitors - chemistry</subject><subject>Lipoxygenase Inhibitors - isolation & purification</subject><subject>Lipoxygenase Inhibitors - pharmacology</subject><subject>Medical sciences</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>phenolic compounds</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Stems</subject><subject>Plants, Medicinal</subject><subject>Stearates - chemistry</subject><subject>Stearates - isolation & purification</subject><subject>Stearates - pharmacology</subject><subject>stems</subject><issn>0032-0943</issn><issn>1439-0221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10L9v1DAYxnELgei1MLKCB8RE4H1tJzmPqIJSVKkDdMXyz56rJD7sHOX--_rISXRh8vLxY-tLyCuEDwht-7E0DKBrZAdrxCdkhYLLBhjDp2QFwFkDUvATclrKHQAKCfCcnCAIXHPercjPyd_T7cZPaYiWBj3Pe6ptdNSX2Wd6H-cNHeI2_dnf-kkXT-O0iSbOKR_cHH_HeiHkNNJv2uqsJ6dpiHUrhrqoX5BnQQ_FvzyeZ-Tmy-cf51-bq-uLy_NPV43lvZwb7lp0vTUGRY-CGWM9APOuQ2bFWtvQO8YDE20nOGBvgkEjnJYGOsNcC_yMvFt2tzn92tW_qzEW64dBTz7tiuqkZND_hc0CbU6lZB_UNsdR571CUIegqqhDULUErf71cXhnRu8e6aVgBW-PQBerh1AT2Fj-uYoQZGXvFzZvoh-9uku7PNUi_332zcKDTkrf5rp4850BcmCSC2x7_gC_F5V2</recordid><startdate>19990601</startdate><enddate>19990601</enddate><creator>Ali, R.M</creator><creator>Houghton, P.J</creator><general>Thieme</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990601</creationdate><title>new phenolic fatty acid ester with lipoxygenase inhibitory activity from Jacaranda filicifolia</title><author>Ali, R.M ; Houghton, P.J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-3d51d7cbb147142bbce002ed612c48acf7d23f245643017bfb1b4da9b06b2d503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Biological and medical sciences</topic><topic>chemical constituents of plants</topic><topic>chemical structure</topic><topic>enzyme inhibitors</topic><topic>esters</topic><topic>fatty acids</topic><topic>fractionation</topic><topic>General pharmacology</topic><topic>Jacaranda</topic><topic>Letter</topic><topic>lipoxygenase</topic><topic>Lipoxygenase Inhibitors - chemistry</topic><topic>Lipoxygenase Inhibitors - isolation & purification</topic><topic>Lipoxygenase Inhibitors - pharmacology</topic><topic>Medical sciences</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>phenolic compounds</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Stems</topic><topic>Plants, Medicinal</topic><topic>Stearates - chemistry</topic><topic>Stearates - isolation & purification</topic><topic>Stearates - pharmacology</topic><topic>stems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ali, R.M</creatorcontrib><creatorcontrib>Houghton, P.J</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Planta medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ali, R.M</au><au>Houghton, P.J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>new phenolic fatty acid ester with lipoxygenase inhibitory activity from Jacaranda filicifolia</atitle><jtitle>Planta medica</jtitle><addtitle>Planta Med</addtitle><date>1999-06-01</date><risdate>1999</risdate><volume>65</volume><issue>5</issue><spage>455</spage><epage>457</epage><pages>455-457</pages><issn>0032-0943</issn><eissn>1439-0221</eissn><coden>PLMEAA</coden><abstract>Abstract
The dichloromethane extract of the stem of JACARANDA FILICIFOLIA Don. showed inhibitory activity IN VITRO against soybean 5-lipoxygenase. Systematic fractionation to isolate the compounds responsible resulted in the isolation of three active compounds, 2α,3α-dihydroxyurs-12-en-28-oic acid, β-sitosterol, and one of which was new which was characterised as 2-(4-hydroxyphenyl)ethyl 1-dodecyloctadecanoate. This type of compound has not previously been reported to inhibit lipoxygenase.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>10418336</pmid><doi>10.1055/s-2006-960811</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0032-0943 |
| ispartof | Planta medica, 1999-06, Vol.65 (5), p.455-457 |
| issn | 0032-0943 1439-0221 |
| language | eng |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Biological and medical sciences chemical constituents of plants chemical structure enzyme inhibitors esters fatty acids fractionation General pharmacology Jacaranda Letter lipoxygenase Lipoxygenase Inhibitors - chemistry Lipoxygenase Inhibitors - isolation & purification Lipoxygenase Inhibitors - pharmacology Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phenolic compounds Plant Extracts - chemistry Plant Extracts - pharmacology Plant Stems Plants, Medicinal Stearates - chemistry Stearates - isolation & purification Stearates - pharmacology stems |
| title | new phenolic fatty acid ester with lipoxygenase inhibitory activity from Jacaranda filicifolia |
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