new phenolic fatty acid ester with lipoxygenase inhibitory activity from Jacaranda filicifolia

Abstract The dichloromethane extract of the stem of JACARANDA FILICIFOLIA Don. showed inhibitory activity IN VITRO against soybean 5-lipoxygenase. Systematic fractionation to isolate the compounds responsible resulted in the isolation of three active compounds, 2α,3α-dihydroxyurs-12-en-28-oic acid,...

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Veröffentlicht in:	Planta medica 1999-06, Vol.65 (5), p.455-457
Hauptverfasser:	Ali, R.M, Houghton, P.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences chemical constituents of plants chemical structure enzyme inhibitors esters fatty acids fractionation General pharmacology Jacaranda Letter lipoxygenase Lipoxygenase Inhibitors - chemistry Lipoxygenase Inhibitors - isolation & purification Lipoxygenase Inhibitors - pharmacology Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phenolic compounds Plant Extracts - chemistry Plant Extracts - pharmacology Plant Stems Plants, Medicinal Stearates - chemistry Stearates - isolation & purification Stearates - pharmacology stems
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Zusammenfassung:	Abstract The dichloromethane extract of the stem of JACARANDA FILICIFOLIA Don. showed inhibitory activity IN VITRO against soybean 5-lipoxygenase. Systematic fractionation to isolate the compounds responsible resulted in the isolation of three active compounds, 2α,3α-dihydroxyurs-12-en-28-oic acid, β-sitosterol, and one of which was new which was characterised as 2-(4-hydroxyphenyl)ethyl 1-dodecyloctadecanoate. This type of compound has not previously been reported to inhibit lipoxygenase.
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-2006-960811