Differing effect of protein isolates from different cultivars of blue lupin [Lupinus angustifolius] on plasma lipoproteins of hypercholesterolemic rats
Protein from white lupin is capable of lowering plasma lipids. We investigated in this study the effect of total protein extracts (TPEs) from different cultivars of blue lupin (Probor, Vitabor and Boregine) and alpha-/beta-conglutin from Boregine on the plasma lipids of rats. Rats were fed on a hype...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2008-12, Vol.72 (12), p.3114-3121 |
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| creator | Bettzieche, A.(Martin-Luther-Univ., Halle-Wittenberg (Germany)) Brandsch, C Schmidt, M Weibe, K Eder, K Stangl, G.I |
| description | Protein from white lupin is capable of lowering plasma lipids. We investigated in this study the effect of total protein extracts (TPEs) from different cultivars of blue lupin (Probor, Vitabor and Boregine) and alpha-/beta-conglutin from Boregine on the plasma lipids of rats. Rats were fed on a hypercholesterolemic diet containing either lupin protein (50 g/kg) or casein (50 g/kg) for 17 d. The rats fed with TPE from Vitabor and alpha-/beta-conglutin had lower triglyceride concentrations in the plasma (-24% and -21%, respectively) and very-low-density lipoprotein (VLDL; -40% and -29%, respectively) than the rats fed with casein. TPE from Vitabor was also capable of lowering low-density lipoprotein (LDL) cholesterol (-37%). In the liver of the rats fed with TPE from Vitabor, the expression of the genes involved in triglyceride and cholesterol synthesis was down-regulated. This study shows that the Vitabor cultivar of blue lupin had the most beneficial effect on plasma lipids which was presumed to have been caused by the down-regulation of genes involved in lipid synthesis. |
| doi_str_mv | 10.1271/bbb.80221 |
| format | Article |
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We investigated in this study the effect of total protein extracts (TPEs) from different cultivars of blue lupin (Probor, Vitabor and Boregine) and alpha-/beta-conglutin from Boregine on the plasma lipids of rats. Rats were fed on a hypercholesterolemic diet containing either lupin protein (50 g/kg) or casein (50 g/kg) for 17 d. The rats fed with TPE from Vitabor and alpha-/beta-conglutin had lower triglyceride concentrations in the plasma (-24% and -21%, respectively) and very-low-density lipoprotein (VLDL; -40% and -29%, respectively) than the rats fed with casein. TPE from Vitabor was also capable of lowering low-density lipoprotein (LDL) cholesterol (-37%). In the liver of the rats fed with TPE from Vitabor, the expression of the genes involved in triglyceride and cholesterol synthesis was down-regulated. This study shows that the Vitabor cultivar of blue lupin had the most beneficial effect on plasma lipids which was presumed to have been caused by the down-regulation of genes involved in lipid synthesis.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.80221</identifier><identifier>PMID: 19060384</identifier><language>eng</language><publisher>Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry</publisher><subject>Animals ; Bile Acids and Salts - genetics ; Bile Acids and Salts - metabolism ; Biological and medical sciences ; Body Weight - drug effects ; Cholesterol - blood ; Cholesterol - genetics ; EXPRESION GENICA ; EXPRESSION DES GENES ; EXTRACTOS VEGETALES ; EXTRAIT D'ORIGINE VEGETALE ; FOIE ; Fundamental and applied biological sciences. Psychology ; GENE EXPRESSION ; Gene Expression Regulation - drug effects ; hepatic gene expression ; HIGADO ; Hypercholesterolemia - blood ; Hypercholesterolemia - drug therapy ; Hypercholesterolemia - pathology ; LIPOPROTEINAS ; LIPOPROTEINE ; LIPOPROTEINS ; Lipoproteins - blood ; LIVER ; Liver - drug effects ; Liver - pathology ; lupin protein ; Lupinus - chemistry ; LUPINUS ANGUSTIFOLIUS ; Male ; Organ Size - drug effects ; PLANT EXTRACTS ; Plant Proteins - isolation & purification ; Plant Proteins - pharmacology ; Plant Proteins - therapeutic use ; plasma lipoprotein ; PROTEINAS ; PROTEINE ; PROTEINS ; RAT ; RATA ; RATS ; Rats, Sprague-Dawley ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Triglycerides - blood ; Triglycerides - genetics</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2008-12, Vol.72 (12), p.3114-3121</ispartof><rights>2008 by Japan Society for Bioscience, Biotechnology, and Agrochemistry 2008</rights><rights>2009 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c655t-8ba4075c6f310eb2b78520da06bdafed49cbcd9d6c566a1745be321c31c2ed663</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21079864$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19060384$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bettzieche, A.(Martin-Luther-Univ., Halle-Wittenberg (Germany))</creatorcontrib><creatorcontrib>Brandsch, C</creatorcontrib><creatorcontrib>Schmidt, M</creatorcontrib><creatorcontrib>Weibe, K</creatorcontrib><creatorcontrib>Eder, K</creatorcontrib><creatorcontrib>Stangl, G.I</creatorcontrib><title>Differing effect of protein isolates from different cultivars of blue lupin [Lupinus angustifolius] on plasma lipoproteins of hypercholesterolemic rats</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>Protein from white lupin is capable of lowering plasma lipids. We investigated in this study the effect of total protein extracts (TPEs) from different cultivars of blue lupin (Probor, Vitabor and Boregine) and alpha-/beta-conglutin from Boregine on the plasma lipids of rats. Rats were fed on a hypercholesterolemic diet containing either lupin protein (50 g/kg) or casein (50 g/kg) for 17 d. The rats fed with TPE from Vitabor and alpha-/beta-conglutin had lower triglyceride concentrations in the plasma (-24% and -21%, respectively) and very-low-density lipoprotein (VLDL; -40% and -29%, respectively) than the rats fed with casein. TPE from Vitabor was also capable of lowering low-density lipoprotein (LDL) cholesterol (-37%). In the liver of the rats fed with TPE from Vitabor, the expression of the genes involved in triglyceride and cholesterol synthesis was down-regulated. This study shows that the Vitabor cultivar of blue lupin had the most beneficial effect on plasma lipids which was presumed to have been caused by the down-regulation of genes involved in lipid synthesis.</description><subject>Animals</subject><subject>Bile Acids and Salts - genetics</subject><subject>Bile Acids and Salts - metabolism</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>Cholesterol - blood</subject><subject>Cholesterol - genetics</subject><subject>EXPRESION GENICA</subject><subject>EXPRESSION DES GENES</subject><subject>EXTRACTOS VEGETALES</subject><subject>EXTRAIT D'ORIGINE VEGETALE</subject><subject>FOIE</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GENE EXPRESSION</subject><subject>Gene Expression Regulation - drug effects</subject><subject>hepatic gene expression</subject><subject>HIGADO</subject><subject>Hypercholesterolemia - blood</subject><subject>Hypercholesterolemia - drug therapy</subject><subject>Hypercholesterolemia - pathology</subject><subject>LIPOPROTEINAS</subject><subject>LIPOPROTEINE</subject><subject>LIPOPROTEINS</subject><subject>Lipoproteins - blood</subject><subject>LIVER</subject><subject>Liver - drug effects</subject><subject>Liver - pathology</subject><subject>lupin protein</subject><subject>Lupinus - chemistry</subject><subject>LUPINUS ANGUSTIFOLIUS</subject><subject>Male</subject><subject>Organ Size - drug effects</subject><subject>PLANT EXTRACTS</subject><subject>Plant Proteins - isolation & purification</subject><subject>Plant Proteins - pharmacology</subject><subject>Plant Proteins - therapeutic use</subject><subject>plasma lipoprotein</subject><subject>PROTEINAS</subject><subject>PROTEINE</subject><subject>PROTEINS</subject><subject>RAT</subject><subject>RATA</subject><subject>RATS</subject><subject>Rats, Sprague-Dawley</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Triglycerides - blood</subject><subject>Triglycerides - genetics</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0s2KFDEQAOBGFHdcPfgASkAUPMyav053jrL-M6AHPYk0lXQymyXdaZOOMk_i65qeaRVE8FQhfFWppFJV9wm-ILQhz5RSFy2mlNyoNoTxZiskb25WGyyJ2La8JmfVnZSuMS4bNbldnRGJBWYt31Q_XjhrTXTjHpmy0DMKFk0xzMaNyKXgYTYJ2RgG1B-lGWeks5_dN4hpwcpng3yeiv-8W0JOCMZ9TrOzwbucvqAwoslDGgB5N4W1-jH56jCZqK-CN2k2sYTBaRRhTnerWxZ8MvfWeF59evXy4-Wb7e7967eXz3dbLep63rYKOG5qLSwj2CiqmramuAcsVA_W9FxqpXvZC10LAaThtTKMEs2IpqYXgp1XT051S1dfc-miG1zSxnsYTcipE1ISyVryX0jLe7Z1Uxf46C94HXIcyyU6wrlsmZR0OffpSekYUorGdlN0A8RDR3C3DLUrQ-2OQy324Voxq8H0f-Q6xQIerwCSBm8jjNql344S3MhWLI6fnBttiAN8D9H33QwHH-KvJPav8x-c0iyEDvaxqHcfaPlM5UM1lLKfcJfIQw</recordid><startdate>20081201</startdate><enddate>20081201</enddate><creator>Bettzieche, A.(Martin-Luther-Univ., Halle-Wittenberg (Germany))</creator><creator>Brandsch, C</creator><creator>Schmidt, M</creator><creator>Weibe, K</creator><creator>Eder, K</creator><creator>Stangl, G.I</creator><general>Japan Society for Bioscience, Biotechnology, and Agrochemistry</general><general>Japan Society for Bioscience Biotechnology and Agrochemistry</general><general>Oxford University Press</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20081201</creationdate><title>Differing effect of protein isolates from different cultivars of blue lupin [Lupinus angustifolius] on plasma lipoproteins of hypercholesterolemic rats</title><author>Bettzieche, A.(Martin-Luther-Univ., Halle-Wittenberg (Germany)) ; Brandsch, C ; Schmidt, M ; Weibe, K ; Eder, K ; Stangl, G.I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c655t-8ba4075c6f310eb2b78520da06bdafed49cbcd9d6c566a1745be321c31c2ed663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Bile Acids and Salts - genetics</topic><topic>Bile Acids and Salts - metabolism</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>Cholesterol - blood</topic><topic>Cholesterol - genetics</topic><topic>EXPRESION GENICA</topic><topic>EXPRESSION DES GENES</topic><topic>EXTRACTOS VEGETALES</topic><topic>EXTRAIT D'ORIGINE VEGETALE</topic><topic>FOIE</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GENE EXPRESSION</topic><topic>Gene Expression Regulation - drug effects</topic><topic>hepatic gene expression</topic><topic>HIGADO</topic><topic>Hypercholesterolemia - blood</topic><topic>Hypercholesterolemia - drug therapy</topic><topic>Hypercholesterolemia - pathology</topic><topic>LIPOPROTEINAS</topic><topic>LIPOPROTEINE</topic><topic>LIPOPROTEINS</topic><topic>Lipoproteins - blood</topic><topic>LIVER</topic><topic>Liver - drug effects</topic><topic>Liver - pathology</topic><topic>lupin protein</topic><topic>Lupinus - chemistry</topic><topic>LUPINUS ANGUSTIFOLIUS</topic><topic>Male</topic><topic>Organ Size - drug effects</topic><topic>PLANT EXTRACTS</topic><topic>Plant Proteins - isolation & purification</topic><topic>Plant Proteins - pharmacology</topic><topic>Plant Proteins - therapeutic use</topic><topic>plasma lipoprotein</topic><topic>PROTEINAS</topic><topic>PROTEINE</topic><topic>PROTEINS</topic><topic>RAT</topic><topic>RATA</topic><topic>RATS</topic><topic>Rats, Sprague-Dawley</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Triglycerides - blood</topic><topic>Triglycerides - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bettzieche, A.(Martin-Luther-Univ., Halle-Wittenberg (Germany))</creatorcontrib><creatorcontrib>Brandsch, C</creatorcontrib><creatorcontrib>Schmidt, M</creatorcontrib><creatorcontrib>Weibe, K</creatorcontrib><creatorcontrib>Eder, K</creatorcontrib><creatorcontrib>Stangl, G.I</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bettzieche, A.(Martin-Luther-Univ., Halle-Wittenberg (Germany))</au><au>Brandsch, C</au><au>Schmidt, M</au><au>Weibe, K</au><au>Eder, K</au><au>Stangl, G.I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differing effect of protein isolates from different cultivars of blue lupin [Lupinus angustifolius] on plasma lipoproteins of hypercholesterolemic rats</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2008-12-01</date><risdate>2008</risdate><volume>72</volume><issue>12</issue><spage>3114</spage><epage>3121</epage><pages>3114-3121</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>Protein from white lupin is capable of lowering plasma lipids. We investigated in this study the effect of total protein extracts (TPEs) from different cultivars of blue lupin (Probor, Vitabor and Boregine) and alpha-/beta-conglutin from Boregine on the plasma lipids of rats. Rats were fed on a hypercholesterolemic diet containing either lupin protein (50 g/kg) or casein (50 g/kg) for 17 d. The rats fed with TPE from Vitabor and alpha-/beta-conglutin had lower triglyceride concentrations in the plasma (-24% and -21%, respectively) and very-low-density lipoprotein (VLDL; -40% and -29%, respectively) than the rats fed with casein. TPE from Vitabor was also capable of lowering low-density lipoprotein (LDL) cholesterol (-37%). In the liver of the rats fed with TPE from Vitabor, the expression of the genes involved in triglyceride and cholesterol synthesis was down-regulated. This study shows that the Vitabor cultivar of blue lupin had the most beneficial effect on plasma lipids which was presumed to have been caused by the down-regulation of genes involved in lipid synthesis.</abstract><cop>Tokyo</cop><pub>Japan Society for Bioscience, Biotechnology, and Agrochemistry</pub><pmid>19060384</pmid><doi>10.1271/bbb.80221</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Bioscience, biotechnology, and biochemistry, 2008-12, Vol.72 (12), p.3114-3121 |
| issn | 0916-8451 1347-6947 |
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| recordid | cdi_proquest_miscellaneous_69919381 |
| source | J-STAGE Free; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Freely Accessible Japanese Titles; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Bile Acids and Salts - genetics Bile Acids and Salts - metabolism Biological and medical sciences Body Weight - drug effects Cholesterol - blood Cholesterol - genetics EXPRESION GENICA EXPRESSION DES GENES EXTRACTOS VEGETALES EXTRAIT D'ORIGINE VEGETALE FOIE Fundamental and applied biological sciences. Psychology GENE EXPRESSION Gene Expression Regulation - drug effects hepatic gene expression HIGADO Hypercholesterolemia - blood Hypercholesterolemia - drug therapy Hypercholesterolemia - pathology LIPOPROTEINAS LIPOPROTEINE LIPOPROTEINS Lipoproteins - blood LIVER Liver - drug effects Liver - pathology lupin protein Lupinus - chemistry LUPINUS ANGUSTIFOLIUS Male Organ Size - drug effects PLANT EXTRACTS Plant Proteins - isolation & purification Plant Proteins - pharmacology Plant Proteins - therapeutic use plasma lipoprotein PROTEINAS PROTEINE PROTEINS RAT RATA RATS Rats, Sprague-Dawley RNA, Messenger - genetics RNA, Messenger - metabolism Triglycerides - blood Triglycerides - genetics |
| title | Differing effect of protein isolates from different cultivars of blue lupin [Lupinus angustifolius] on plasma lipoproteins of hypercholesterolemic rats |
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