The additionally glycosylated variant of human sex hormone-binding globulin (SHBG) is linked to estrogen-dependence of breast cancer

Sex Hormone-Binding Globulin (SHBG), the plasma carrier for androgens and estradiol, inhibits the estradiol-induced proliferation of breast cancer cells through its membrane receptor, cAMP, and PKA. In addition, the SHBG membrane receptor is preferentially expressed in estrogen-dependent (ER+/PR+) b...

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Veröffentlicht in:	Breast cancer research and treatment 1999-03, Vol.54 (2), p.101-107
Hauptverfasser:	BECCHIS, M, FRAIRIA, R, FERRERA, P, FAZZARI, A, ONDEI, S, ALFARANO, A, COLUCCIA, C, BIGLIA, N, SISMONDI, P, FORTUNATI, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Arginine Asparagine Base Sequence Biological and medical sciences Breast - cytology Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer research Cancer therapies Cell Division - drug effects Estradiol - pharmacology Exons Female Fibrocystic Breast Disease - genetics Fibrocystic Breast Disease - pathology Genetic Variation Glycosylation Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Point Mutation Polymorphism, Restriction Fragment Length Reference Values Sex Hormone-Binding Globulin - chemistry Sex Hormone-Binding Globulin - genetics Sex Hormone-Binding Globulin - metabolism Tumors
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